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BDBM50224997 2-(4-(2-(1-(4-chlorobenzyl)piperidin-2-yl)ethoxy)phenyl)-1H-benzo[d]imidazole-5-carboxamide::CHEMBL398529

SMILES: NC(=O)c1ccc2nc([nH]c2c1)-c1ccc(OCCC2CCCCN2Cc2ccc(Cl)cc2)cc1

InChI Key: InChIKey=OLGDSVAGYXUQFQ-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50224997   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase CHK2


(Homo sapiens (Human))
BDBM50224997
PNG
(2-(4-(2-(1-(4-chlorobenzyl)piperidin-2-yl)ethoxy)p...)
Show SMILES NC(=O)c1ccc2nc([nH]c2c1)-c1ccc(OCCC2CCCCN2Cc2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C28H29ClN4O2/c29-22-9-4-19(5-10-22)18-33-15-2-1-3-23(33)14-16-35-24-11-6-20(7-12-24)28-31-25-13-8-21(27(30)34)17-26(25)32-28/h4-13,17,23H,1-3,14-16,18H2,(H2,30,34)(H,31,32)
PDB
MMDB

KEGG

UniProtKB/SwissProt

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antibodypedia
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CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 53n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Chk2


Bioorg Med Chem Lett 17: 6467-71 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.098
BindingDB Entry DOI: 10.7270/Q2KP81XB
More data for this
Ligand-Target Pair