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BDBM50225012 2-(4-{2-[1-(4-methyl-benzyl)-piperidin-2-yl]-ethoxy}-phenyl)-1H-benzoimidazole-5-carboxylic acid amide::CHEMBL250759

SMILES: Cc1ccc(CN2CCCCC2CCOc2ccc(cc2)-c2nc3ccc(cc3[nH]2)C(N)=O)cc1

InChI Key: InChIKey=RYABHZCNNGZUHA-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50225012   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase CHK2


(Homo sapiens (Human))
BDBM50225012
PNG
(2-(4-{2-[1-(4-methyl-benzyl)-piperidin-2-yl]-ethox...)
Show SMILES Cc1ccc(CN2CCCCC2CCOc2ccc(cc2)-c2nc3ccc(cc3[nH]2)C(N)=O)cc1
Show InChI InChI=1S/C29H32N4O2/c1-20-5-7-21(8-6-20)19-33-16-3-2-4-24(33)15-17-35-25-12-9-22(10-13-25)29-31-26-14-11-23(28(30)34)18-27(26)32-29/h5-14,18,24H,2-4,15-17,19H2,1H3,(H2,30,34)(H,31,32)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
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CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 61n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Chk2


Bioorg Med Chem Lett 17: 6467-71 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.098
BindingDB Entry DOI: 10.7270/Q2KP81XB
More data for this
Ligand-Target Pair