BindingDB PrimarySearch

BDBM50225074 (1S,3S,5S)-2-[(S)-2-amino-2-(3-hydroxy-adamantan-1-yl)-acetyl]-2-aza-bicyclo[3.1.0]hexane-3-carbonitrile::(1S,6S)-2-(2-adamantan-1-yl-2-amino-acetyl)-2-aza-bicyclo[3.1.0]hexane-3-carbonitrile::BMS-477118::CHEMBL385517::SAXAGLIPTIN

SMILES: N[C@H](C(=O)N1[C@H]2C[C@H]2C[C@H]1C#N)C12CC3CC(CC(O)(C3)C1)C2

InChI Key: InChIKey=QGJUIPDUBHWZPV-SGTAVMJGSA-N

Data: 3 KI 33 IC50 2 Kd

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 38 hits for monomerid = 50225074
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Dipeptidyl peptidase 4 (Homo sapiens (Human))	BDBM50225074 ((1S,3S,5S)-2-[(S)-2-amino-2-(3-hydroxy-adamantan-1...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars	DrugBank Article PubMed	0.600	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Matrix Laboratories Limited Curated by ChEMBL					Assay Description Inhibition of human DPP4				Bioorg Med Chem 17: 1783-802 (2009) Article DOI: 10.1016/j.bmc.2009.01.061 BindingDB Entry DOI: 10.7270/Q2VD70DJ
Matrix Laboratories Limited Curated by ChEMBL					More data for this Ligand-Target Pair
Dipeptidyl peptidase 4 (Homo sapiens (Human))	BDBM50225074 ((1S,3S,5S)-2-[(S)-2-amino-2-(3-hydroxy-adamantan-1...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars	DrugBank Article PubMed	0.600	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Research and Development Curated by ChEMBL					Assay Description Inhibition of human DPP4				Bioorg Med Chem Lett 17: 6476-80 (2007) Article DOI: 10.1016/j.bmcl.2007.09.090 BindingDB Entry DOI: 10.7270/Q2B56JGM
					More data for this Ligand-Target Pair
Dipeptidyl peptidase 4 (Homo sapiens (Human))	BDBM50225074 ((1S,3S,5S)-2-[(S)-2-amino-2-(3-hydroxy-adamantan-1...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars	DrugBank Article PubMed	0.600	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Sichuan University Curated by ChEMBL					Assay Description Inhibition of DPP4				Eur J Med Chem 44: 3318-22 (2009) Article DOI: 10.1016/j.ejmech.2009.03.021 BindingDB Entry DOI: 10.7270/Q2DR2WGQ
Sichuan University Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 2B6 (Homo sapiens (Human))	BDBM50225074 ((1S,3S,5S)-2-[(S)-2-amino-2-(3-hydroxy-adamantan-1...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Research Curated by ChEMBL					Assay Description Inhibition of CYP2B6 in human liver microsomes assessed as bupropion hydroxylation after 3 mins by LC-MS/MS analysis in presence of NADPH				Drug Metab Dispos 40: 1345-56 (2012) Article DOI: 10.1124/dmd.112.045450 BindingDB Entry DOI: 10.7270/Q27D2WVN
Bristol-Myers Squibb Research Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 2C8 (Homo sapiens (Human))	BDBM50225074 ((1S,3S,5S)-2-[(S)-2-amino-2-(3-hydroxy-adamantan-1...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Research Curated by ChEMBL					Assay Description Inhibition of CYP2C8 in human liver microsomes assessed as paclitaxel 6alpha-hydroxylation after 3 mins by LC-MS/MS analysis in presence of NADPH				Drug Metab Dispos 40: 1345-56 (2012) Article DOI: 10.1124/dmd.112.045450 BindingDB Entry DOI: 10.7270/Q27D2WVN
Bristol-Myers Squibb Research Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 2C9 (Homo sapiens (Human))	BDBM50225074 ((1S,3S,5S)-2-[(S)-2-amino-2-(3-hydroxy-adamantan-1...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Research Curated by ChEMBL					Assay Description Inhibition of CYP2C9 in human liver microsomes assessed as paclitaxel 6alpha-hydroxylation after 3 mins by LC-MS/MS analysis in presence of NADPH				Drug Metab Dispos 40: 1345-56 (2012) Article DOI: 10.1124/dmd.112.045450 BindingDB Entry DOI: 10.7270/Q27D2WVN
Bristol-Myers Squibb Research Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 2C19 (Homo sapiens (Human))	BDBM50225074 ((1S,3S,5S)-2-[(S)-2-amino-2-(3-hydroxy-adamantan-1...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Research Curated by ChEMBL					Assay Description Inhibition of CYP2C19 in human liver microsomes assessed as (S)-mephenytoin 4'-hydroxylation after 3 mins by LC-MS/MS analysis				Drug Metab Dispos 40: 1345-56 (2012) Article DOI: 10.1124/dmd.112.045450 BindingDB Entry DOI: 10.7270/Q27D2WVN
Bristol-Myers Squibb Research Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 2D6 (Homo sapiens (Human))	BDBM50225074 ((1S,3S,5S)-2-[(S)-2-amino-2-(3-hydroxy-adamantan-1...) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Research Curated by ChEMBL					Assay Description Inhibition of CYP2D6 in human liver microsomes assessed as bufuralol 1'-hydroxylation after 3 mins by LC-MS/MS analysis				Drug Metab Dispos 40: 1345-56 (2012) Article DOI: 10.1124/dmd.112.045450 BindingDB Entry DOI: 10.7270/Q27D2WVN
Bristol-Myers Squibb Research Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 2E1 (Homo sapiens (Human))	BDBM50225074 ((1S,3S,5S)-2-[(S)-2-amino-2-(3-hydroxy-adamantan-1...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Research Curated by ChEMBL					Assay Description Inhibition of CYP2E1 in human liver microsomes assessed as chlorzoxazone 6-hydroxylation after 3 mins by LC-MS/MS analysis in presence of NADPH				Drug Metab Dispos 40: 1345-56 (2012) Article DOI: 10.1124/dmd.112.045450 BindingDB Entry DOI: 10.7270/Q27D2WVN
Bristol-Myers Squibb Research Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM50225074 ((1S,3S,5S)-2-[(S)-2-amino-2-(3-hydroxy-adamantan-1...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars	DrugBank Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Research Curated by ChEMBL					Assay Description Inhibition of CYP3A4 in human liver microsomes assessed as midazolam 1'-hydroxylation after 3 mins by LC-MS/MS analysis				Drug Metab Dispos 40: 1345-56 (2012) Article DOI: 10.1124/dmd.112.045450 BindingDB Entry DOI: 10.7270/Q27D2WVN
Bristol-Myers Squibb Research Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM50225074 ((1S,3S,5S)-2-[(S)-2-amino-2-(3-hydroxy-adamantan-1...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars	DrugBank Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Research Curated by ChEMBL					Assay Description Inhibition of CYP3A4 in human liver microsomes assessed as testosterone 6beta-hydroxylation after 3 mins by LC-MS/MS analysis in presence of NADPH				Drug Metab Dispos 40: 1345-56 (2012) Article DOI: 10.1124/dmd.112.045450 BindingDB Entry DOI: 10.7270/Q27D2WVN
Bristol-Myers Squibb Research Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 1A (Homo sapiens (Human))	BDBM50225074 ((1S,3S,5S)-2-[(S)-2-amino-2-(3-hydroxy-adamantan-1...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Research Curated by ChEMBL					Assay Description Inhibition of CYP1A2 in human liver microsomes assessed as phenacetin O-deethylation preincubated for 15 mins by LC-MS/MS analysis in presence of NAD...				Drug Metab Dispos 40: 1345-56 (2012) Article DOI: 10.1124/dmd.112.045450 BindingDB Entry DOI: 10.7270/Q27D2WVN
Bristol-Myers Squibb Research Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 2A6 (Homo sapiens (Human))	BDBM50225074 ((1S,3S,5S)-2-[(S)-2-amino-2-(3-hydroxy-adamantan-1...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Research Curated by ChEMBL					Assay Description Inhibition of CYP2A6 in human liver microsomes assessed as coumarin 7-hydroxylation preincubated for 15 mins by LC-MS/MS analysis in presence of NADP...				Drug Metab Dispos 40: 1345-56 (2012) Article DOI: 10.1124/dmd.112.045450 BindingDB Entry DOI: 10.7270/Q27D2WVN
Bristol-Myers Squibb Research Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 2B6 (Homo sapiens (Human))	BDBM50225074 ((1S,3S,5S)-2-[(S)-2-amino-2-(3-hydroxy-adamantan-1...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Research Curated by ChEMBL					Assay Description Inhibition of CYP2B6 in human liver microsomes assessed as bupropion hydroxylation preincubated for 15 mins by LC-MS/MS analysis in presence of NADPH				Drug Metab Dispos 40: 1345-56 (2012) Article DOI: 10.1124/dmd.112.045450 BindingDB Entry DOI: 10.7270/Q27D2WVN
Bristol-Myers Squibb Research Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 2C8 (Homo sapiens (Human))	BDBM50225074 ((1S,3S,5S)-2-[(S)-2-amino-2-(3-hydroxy-adamantan-1...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Research Curated by ChEMBL					Assay Description Inhibition of CYP2C8 in human liver microsomes assessed as paclitaxel 6alpha-hydroxylation preincubated for 15 mins by LC-MS/MS analysis in presence ...				Drug Metab Dispos 40: 1345-56 (2012) Article DOI: 10.1124/dmd.112.045450 BindingDB Entry DOI: 10.7270/Q27D2WVN
Bristol-Myers Squibb Research Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 2C9 (Homo sapiens (Human))	BDBM50225074 ((1S,3S,5S)-2-[(S)-2-amino-2-(3-hydroxy-adamantan-1...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Research Curated by ChEMBL					Assay Description Inhibition of CYP2C9 in human liver microsomes assessed as paclitaxel 6alpha-hydroxylation preincubated for 15 mins by LC-MS/MS analysis in presence ...				Drug Metab Dispos 40: 1345-56 (2012) Article DOI: 10.1124/dmd.112.045450 BindingDB Entry DOI: 10.7270/Q27D2WVN
Bristol-Myers Squibb Research Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 2C19 (Homo sapiens (Human))	BDBM50225074 ((1S,3S,5S)-2-[(S)-2-amino-2-(3-hydroxy-adamantan-1...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Research Curated by ChEMBL					Assay Description Inhibition of CYP2C19 in human liver microsomes assessed as (S)-mephenytoin 4'-hydroxylation preincubated for 15 mins by LC-MS/MS analysis				Drug Metab Dispos 40: 1345-56 (2012) Article DOI: 10.1124/dmd.112.045450 BindingDB Entry DOI: 10.7270/Q27D2WVN
Bristol-Myers Squibb Research Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 2D6 (Homo sapiens (Human))	BDBM50225074 ((1S,3S,5S)-2-[(S)-2-amino-2-(3-hydroxy-adamantan-1...) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Research Curated by ChEMBL					Assay Description Inhibition of CYP2D6 in human liver microsomes assessed as bufuralol 1'-hydroxylation preincubated for 15 mins by LC-MS/MS analysis				Drug Metab Dispos 40: 1345-56 (2012) Article DOI: 10.1124/dmd.112.045450 BindingDB Entry DOI: 10.7270/Q27D2WVN
Bristol-Myers Squibb Research Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 2E1 (Homo sapiens (Human))	BDBM50225074 ((1S,3S,5S)-2-[(S)-2-amino-2-(3-hydroxy-adamantan-1...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Research Curated by ChEMBL					Assay Description Inhibition of CYP2E1 in human liver microsomes assessed as chlorzoxazone 6-hydroxylation preincubated for 15 mins by LC-MS/MS analysis in presence of...				Drug Metab Dispos 40: 1345-56 (2012) Article DOI: 10.1124/dmd.112.045450 BindingDB Entry DOI: 10.7270/Q27D2WVN
Bristol-Myers Squibb Research Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM50225074 ((1S,3S,5S)-2-[(S)-2-amino-2-(3-hydroxy-adamantan-1...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars	DrugBank Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Research Curated by ChEMBL					Assay Description Inhibition of CYP3A4 in human liver microsomes assessed as midazolam 1'-hydroxylation preincubated for 15 mins by LC-MS/MS analysis				Drug Metab Dispos 40: 1345-56 (2012) Article DOI: 10.1124/dmd.112.045450 BindingDB Entry DOI: 10.7270/Q27D2WVN
Bristol-Myers Squibb Research Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM50225074 ((1S,3S,5S)-2-[(S)-2-amino-2-(3-hydroxy-adamantan-1...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars	DrugBank Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Research Curated by ChEMBL					Assay Description Inhibition of CYP3A4 in human liver microsomes assessed as testosterone 6beta-hydroxylation preincubated for 15 mins by LC-MS/MS analysis in presence...				Drug Metab Dispos 40: 1345-56 (2012) Article DOI: 10.1124/dmd.112.045450 BindingDB Entry DOI: 10.7270/Q27D2WVN
Bristol-Myers Squibb Research Curated by ChEMBL					More data for this Ligand-Target Pair
Dipeptidyl peptidase 4 (Homo sapiens (Human))	BDBM50225074 ((1S,3S,5S)-2-[(S)-2-amino-2-(3-hydroxy-adamantan-1...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars	DrugBank Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Phenomix Corporation Curated by ChEMBL					Assay Description Inhibition of human recombinant DPP4 by fluorescence assay				Bioorg Med Chem Lett 19: 4437-40 (2009) Article DOI: 10.1016/j.bmcl.2009.05.048 BindingDB Entry DOI: 10.7270/Q2571C1Z
Phenomix Corporation Curated by ChEMBL					More data for this Ligand-Target Pair
Dipeptidyl peptidase VIII (Homo sapiens (Human))	BDBM50225074 ((1S,3S,5S)-2-[(S)-2-amino-2-(3-hydroxy-adamantan-1...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	240	n/a	n/a	n/a	n/a	n/a	n/a
National Health Research Institutes Curated by ChEMBL					Assay Description Inhibition of DPP8				Bioorg Med Chem Lett 20: 3596-600 (2010) Article DOI: 10.1016/j.bmcl.2010.04.124 BindingDB Entry DOI: 10.7270/Q29Z953W
National Health Research Institutes Curated by ChEMBL					More data for this Ligand-Target Pair
Dipeptidyl peptidase 4 (Homo sapiens (Human))	BDBM50225074 ((1S,3S,5S)-2-[(S)-2-amino-2-(3-hydroxy-adamantan-1...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars	DrugBank Article PubMed	n/a	n/a	3.40	n/a	n/a	n/a	n/a	n/a	n/a
National Health Research Institutes Curated by ChEMBL					Assay Description Inhibition of DPP4				Bioorg Med Chem Lett 20: 3596-600 (2010) Article DOI: 10.1016/j.bmcl.2010.04.124 BindingDB Entry DOI: 10.7270/Q29Z953W
National Health Research Institutes Curated by ChEMBL					More data for this Ligand-Target Pair
Dipeptidyl peptidase 9 (Homo sapiens (Human))	BDBM50225074 ((1S,3S,5S)-2-[(S)-2-amino-2-(3-hydroxy-adamantan-1...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
National Health Research Institutes Curated by ChEMBL					Assay Description Inhibition of DPP9				Bioorg Med Chem Lett 20: 3596-600 (2010) Article DOI: 10.1016/j.bmcl.2010.04.124 BindingDB Entry DOI: 10.7270/Q29Z953W
National Health Research Institutes Curated by ChEMBL					More data for this Ligand-Target Pair
Dipeptidyl peptidase 4 (Homo sapiens (Human))	BDBM50225074 ((1S,3S,5S)-2-[(S)-2-amino-2-(3-hydroxy-adamantan-1...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars	DrugBank Article PubMed	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
University of Antwerp (UA) Curated by ChEMBL					Assay Description Inhibition of DPP4				J Med Chem 54: 5737-46 (2011) Article DOI: 10.1021/jm200383j BindingDB Entry DOI: 10.7270/Q2G73F37
University of Antwerp (UA) Curated by ChEMBL					More data for this Ligand-Target Pair
Dipeptidyl peptidase 4 (Homo sapiens (Human))	BDBM50225074 ((1S,3S,5S)-2-[(S)-2-amino-2-(3-hydroxy-adamantan-1...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars	DrugBank Article PubMed	n/a	n/a	3.40	n/a	n/a	n/a	n/a	n/a	n/a
Dainippon Sumitomo Pharma Co., Ltd Curated by ChEMBL					Assay Description Inhibition of DPP4 in human plasma using Gly-Pro-AMC as substrate by fluorimetric analysis				Bioorg Med Chem 20: 5864-83 (2012) Article DOI: 10.1016/j.bmc.2012.07.046 BindingDB Entry DOI: 10.7270/Q2FX7BJX
Dainippon Sumitomo Pharma Co., Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II) (Homo sapiens (Human))	BDBM50225074 ((1S,3S,5S)-2-[(S)-2-amino-2-(3-hydroxy-adamantan-1...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Dainippon Sumitomo Pharma Co., Ltd Curated by ChEMBL					Assay Description Inhibition of human DPP2 using Lys-Ala-AMC as substrate by fluorimetric analysis				Bioorg Med Chem 20: 5864-83 (2012) Article DOI: 10.1016/j.bmc.2012.07.046 BindingDB Entry DOI: 10.7270/Q2FX7BJX
Dainippon Sumitomo Pharma Co., Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
Dipeptidyl peptidase 9 (Homo sapiens (Human))	BDBM50225074 ((1S,3S,5S)-2-[(S)-2-amino-2-(3-hydroxy-adamantan-1...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	104	n/a	n/a	n/a	n/a	n/a	n/a
Dainippon Sumitomo Pharma Co., Ltd Curated by ChEMBL					Assay Description Inhibition of DPP9				Bioorg Med Chem 20: 5864-83 (2012) Article DOI: 10.1016/j.bmc.2012.07.046 BindingDB Entry DOI: 10.7270/Q2FX7BJX
Dainippon Sumitomo Pharma Co., Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
Dipeptidyl peptidase VIII (Homo sapiens (Human))	BDBM50225074 ((1S,3S,5S)-2-[(S)-2-amino-2-(3-hydroxy-adamantan-1...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	244	n/a	n/a	n/a	n/a	n/a	n/a
Dainippon Sumitomo Pharma Co., Ltd Curated by ChEMBL					Assay Description Inhibition of DPP8				Bioorg Med Chem 20: 5864-83 (2012) Article DOI: 10.1016/j.bmc.2012.07.046 BindingDB Entry DOI: 10.7270/Q2FX7BJX
Dainippon Sumitomo Pharma Co., Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
Dipeptidyl peptidase 4 (Homo sapiens (Human))	BDBM50225074 ((1S,3S,5S)-2-[(S)-2-amino-2-(3-hydroxy-adamantan-1...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars	DrugBank Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of human recombinant DPP-4 using H-Gly-Pro-AMC as substrate after 10 mins by fluorescence assay				Bioorg Med Chem 22: 1383-93 (2014) Article DOI: 10.1016/j.bmc.2013.12.061 BindingDB Entry DOI: 10.7270/Q2KP8537
China Pharmaceutical University Curated by ChEMBL					More data for this Ligand-Target Pair
Dipeptidyl peptidase 4 (Homo sapiens (Human))	BDBM50225074 ((1S,3S,5S)-2-[(S)-2-amino-2-(3-hydroxy-adamantan-1...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars	DrugBank Article PubMed	n/a	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim Pharma GmbH & Co. KG Curated by ChEMBL					Assay Description Binding affinity to human recombinant DPP4 (39 to 766 residues) at 5 uM by isothermal titration calorimetry				J Med Chem 59: 7466-77 (2016) Article DOI: 10.1021/acs.jmedchem.6b00475
					More data for this Ligand-Target Pair
Dipeptidyl peptidase 4 (Homo sapiens (Human))	BDBM50225074 ((1S,3S,5S)-2-[(S)-2-amino-2-(3-hydroxy-adamantan-1...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars	DrugBank Article PubMed	n/a	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim Pharma GmbH & Co. KG Curated by ChEMBL					Assay Description Binding affinity to human recombinant DPP4 (39 to 766 residues) by surface plasmon resonance analysis				J Med Chem 59: 7466-77 (2016) Article DOI: 10.1021/acs.jmedchem.6b00475
					More data for this Ligand-Target Pair
Acyl-protein thioesterase 1/2 (Rattus norvegicus)	BDBM50225074 ((1S,3S,5S)-2-[(S)-2-amino-2-(3-hydroxy-adamantan-1...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	1.72E+6	n/a	n/a	n/a	n/a	n/a	n/a
Peking University First Hospital Curated by ChEMBL					Assay Description Inhibition of FAP in human U87MG cells using Suc-Gly-Pro-AMC as substrate by fluorescence based assay				Bioorg Med Chem Lett 30: (2020)
Peking University First Hospital Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 2A6 (Homo sapiens (Human))	BDBM50225074 ((1S,3S,5S)-2-[(S)-2-amino-2-(3-hydroxy-adamantan-1...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Research Curated by ChEMBL					Assay Description Inhibition of CYP2A6 in human liver microsomes assessed as coumarin 7-hydroxylation after 3 mins by LC-MS/MS analysis in presence of NADPH				Drug Metab Dispos 40: 1345-56 (2012) Article DOI: 10.1124/dmd.112.045450 BindingDB Entry DOI: 10.7270/Q27D2WVN
Bristol-Myers Squibb Research Curated by ChEMBL					More data for this Ligand-Target Pair
Acyl-protein thioesterase 1/2 (Rattus norvegicus)	BDBM50225074 ((1S,3S,5S)-2-[(S)-2-amino-2-(3-hydroxy-adamantan-1...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Peking University First Hospital Curated by ChEMBL					Assay Description Inhibition of FAP (unknown origin)				Bioorg Med Chem Lett 30: (2020)
Peking University First Hospital Curated by ChEMBL					More data for this Ligand-Target Pair
Dipeptidyl peptidase 4 (Homo sapiens (Human))	BDBM50225074 ((1S,3S,5S)-2-[(S)-2-amino-2-(3-hydroxy-adamantan-1...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars	DrugBank Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
CHUV-UNIL Curated by ChEMBL					Assay Description Inhibition of DPP4 (unknown origin)				J Med Chem 57: 2197-212 (2014) Article DOI: 10.1021/jm400658e BindingDB Entry DOI: 10.7270/Q2TB18F1
CHUV-UNIL Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 1A (Homo sapiens (Human))	BDBM50225074 ((1S,3S,5S)-2-[(S)-2-amino-2-(3-hydroxy-adamantan-1...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Research Curated by ChEMBL					Assay Description Inhibition of CYP1A2 in human liver microsomes assessed as phenacetin O-deethylation after 3 mins by LC-MS/MS analysis in presence of NADPH				Drug Metab Dispos 40: 1345-56 (2012) Article DOI: 10.1124/dmd.112.045450 BindingDB Entry DOI: 10.7270/Q27D2WVN
Bristol-Myers Squibb Research Curated by ChEMBL					More data for this Ligand-Target Pair