BDBM50225220 CHEMBL559::D-thyroxine::O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-D-tyrosine::dextrothyroxine
SMILES: N[C@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(O)=O
InChI Key: InChIKey=XUIIKFGFIJCVMT-GFCCVEGCSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Solute carrier organic anion transporter family member 1C1 (Mus musculus) | BDBM50225220 (CHEMBL559 | D-thyroxine | O-(4-hydroxy-3,5-diiodop...) | UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars | Article PubMed | 270 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Tokyo Curated by ChEMBL | Assay Description TP_TRANSPORTER: inhibition of L-T4 uptake in Oatp14-expressing HEK293 cells | Endocrinology 145: 4384-91 (2004) Article DOI: 10.1210/en.2004-0058 BindingDB Entry DOI: 10.7270/Q2251N23 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
thyroid beta (RAT) | BDBM50225220 (CHEMBL559 | D-thyroxine | O-(4-hydroxy-3,5-diiodop...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Ciba Pharmaceuticals Curated by ChEMBL | Assay Description In vitro inhibition of bound [125I]L-T3 rat plasma membrane 3,5,3'' L-triiodothyronine receptor | J Med Chem 38: 695-707 (1995) BindingDB Entry DOI: 10.7270/Q2T43TRC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
thyroid beta (RAT) | BDBM50225220 (CHEMBL559 | D-thyroxine | O-(4-hydroxy-3,5-diiodop...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
Ciba Pharmaceuticals Curated by ChEMBL | Assay Description In vitro inhibition of the bound [125I]L-T3 rat liver nuclear L-triiodothyronine receptor | J Med Chem 38: 695-707 (1995) BindingDB Entry DOI: 10.7270/Q2T43TRC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transthyretin (Homo sapiens (Human)) | BDBM50225220 (CHEMBL559 | D-thyroxine | O-(4-hydroxy-3,5-diiodop...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 7.17E+3 | n/a | n/a | n/a | n/a | 4.4 | n/a |
Institute of Sciences Curated by ChEMBL | Assay Description Inhibition of transthyretin fibril formation at pH 4.4 | J Med Chem 50: 5589-99 (2007) Article DOI: 10.1021/jm0700159 BindingDB Entry DOI: 10.7270/Q2PG1RGD | |||||||||||
More data for this Ligand-Target Pair |