Found 24 hits for monomerid = 50225707 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Glycine receptor subunit alpha-1
(Homo sapiens (Human)) | BDBM50225707
(CHEBI:28973 | Strychnine)Show SMILES [H][C@]12C[C@@]3([H])C4=CCO[C@@]5([H])CC(=O)N6c7ccccc7[C@@]1(CCN2C4)[C@]6([H])[C@@]35[H] |c:5| Show InChI InChI=1S/C21H22N2O2/c24-18-10-16-19-13-9-17-21(6-7-22(17)11-12(13)5-8-25-16)14-3-1-2-4-15(14)23(18)20(19)21/h1-5,13,16-17,19-20H,6-11H2/t13-,16-,17-,19-,20-,21+/m0/s1 | PDB
UniProtKB/SwissProt
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| 5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Displacement of [3H]strychnine from human glycine receptor subunit alpha-1 expressed in HEK293 cell membranes preincubated for 30 mins followed by [3... |
Citation and Details
Article DOI: 10.1021/acs.jnatprod.0c01030 BindingDB Entry DOI: 10.7270/Q2HH6PV6 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Glycine receptor subunit alpha-1
(RAT) | BDBM50225707
(CHEBI:28973 | Strychnine)Show SMILES [H][C@]12C[C@@]3([H])C4=CCO[C@@]5([H])CC(=O)N6c7ccccc7[C@@]1(CCN2C4)[C@]6([H])[C@@]35[H] |c:5| Show InChI InChI=1S/C21H22N2O2/c24-18-10-16-19-13-9-17-21(6-7-22(17)11-12(13)5-8-25-16)14-3-1-2-4-15(14)23(18)20(19)21/h1-5,13,16-17,19-20H,6-11H2/t13-,16-,17-,19-,20-,21+/m0/s1 | PDB
UniProtKB/SwissProt
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| 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The German University in Cairo
Curated by ChEMBL
| Assay Description Displacement of [3H]strychnine from glycine receptor alpha 1 in rat brain synaptic membranes |
J Nat Prod 79: 2997-3005 (2016)
Article DOI: 10.1021/acs.jnatprod.6b00479 BindingDB Entry DOI: 10.7270/Q2QZ2D66 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Glycine receptor subunit alpha-1
(Homo sapiens (Human)) | BDBM50225707
(CHEBI:28973 | Strychnine)Show SMILES [H][C@]12C[C@@]3([H])C4=CCO[C@@]5([H])CC(=O)N6c7ccccc7[C@@]1(CCN2C4)[C@]6([H])[C@@]35[H] |c:5| Show InChI InChI=1S/C21H22N2O2/c24-18-10-16-19-13-9-17-21(6-7-22(17)11-12(13)5-8-25-16)14-3-1-2-4-15(14)23(18)20(19)21/h1-5,13,16-17,19-20H,6-11H2/t13-,16-,17-,19-,20-,21+/m0/s1 | PDB
UniProtKB/SwissProt
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| 23 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The German University in Cairo
Curated by ChEMBL
| Assay Description Displacement of [3H]strychnine from recombinant human glycine receptor alpha 1 expressed in HEK293 cell membranes after 30 mins by liquid scintillati... |
J Nat Prod 79: 2997-3005 (2016)
Article DOI: 10.1021/acs.jnatprod.6b00479 BindingDB Entry DOI: 10.7270/Q2QZ2D66 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Glycine receptor subunit alpha-1
(Homo sapiens (Human)) | BDBM50225707
(CHEBI:28973 | Strychnine)Show SMILES [H][C@]12C[C@@]3([H])C4=CCO[C@@]5([H])CC(=O)N6c7ccccc7[C@@]1(CCN2C4)[C@]6([H])[C@@]35[H] |c:5| Show InChI InChI=1S/C21H22N2O2/c24-18-10-16-19-13-9-17-21(6-7-22(17)11-12(13)5-8-25-16)14-3-1-2-4-15(14)23(18)20(19)21/h1-5,13,16-17,19-20H,6-11H2/t13-,16-,17-,19-,20-,21+/m0/s1 | PDB
UniProtKB/SwissProt
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| 123 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The German University in Cairo
Curated by ChEMBL
| Assay Description Displacement of [3H]strychnine from human glycine receptor subunit alpha-1 expressed in HEK293 cell membranes |
J Nat Prod 82: 2332-2336 (2019)
Article DOI: 10.1021/acs.jnatprod.9b00180 BindingDB Entry DOI: 10.7270/Q2571GB7 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Glycine receptor subunit alpha-1
(Homo sapiens (Human)) | BDBM50225707
(CHEBI:28973 | Strychnine)Show SMILES [H][C@]12C[C@@]3([H])C4=CCO[C@@]5([H])CC(=O)N6c7ccccc7[C@@]1(CCN2C4)[C@]6([H])[C@@]35[H] |c:5| Show InChI InChI=1S/C21H22N2O2/c24-18-10-16-19-13-9-17-21(6-7-22(17)11-12(13)5-8-25-16)14-3-1-2-4-15(14)23(18)20(19)21/h1-5,13,16-17,19-20H,6-11H2/t13-,16-,17-,19-,20-,21+/m0/s1 | PDB
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| n/a | n/a | 93 | n/a | n/a | n/a | n/a | n/a | n/a |
The German University in Cairo
Curated by ChEMBL
| Assay Description Antagonist activity at recombinant human glycine receptor alpha 1 expressed in human tsA201 cells assessed as inhibition of glycine-induced receptor ... |
J Nat Prod 79: 2997-3005 (2016)
Article DOI: 10.1021/acs.jnatprod.6b00479 BindingDB Entry DOI: 10.7270/Q2QZ2D66 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Glycine receptor subunit alpha-1/beta
(Homo sapiens (Human)) | BDBM50225707
(CHEBI:28973 | Strychnine)Show SMILES [H][C@]12C[C@@]3([H])C4=CCO[C@@]5([H])CC(=O)N6c7ccccc7[C@@]1(CCN2C4)[C@]6([H])[C@@]35[H] |c:5| Show InChI InChI=1S/C21H22N2O2/c24-18-10-16-19-13-9-17-21(6-7-22(17)11-12(13)5-8-25-16)14-3-1-2-4-15(14)23(18)20(19)21/h1-5,13,16-17,19-20H,6-11H2/t13-,16-,17-,19-,20-,21+/m0/s1 | PDB
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| n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a | n/a |
The German University in Cairo
Curated by ChEMBL
| Assay Description Antagonist activity at recombinant human glycine receptor alpha 1 beta expressed in human tsA201 cells assessed as inhibition of glycine-induced rece... |
J Nat Prod 79: 2997-3005 (2016)
Article DOI: 10.1021/acs.jnatprod.6b00479 BindingDB Entry DOI: 10.7270/Q2QZ2D66 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Glycine receptor subunit alpha-1
(Homo sapiens (Human)) | BDBM50225707
(CHEBI:28973 | Strychnine)Show SMILES [H][C@]12C[C@@]3([H])C4=CCO[C@@]5([H])CC(=O)N6c7ccccc7[C@@]1(CCN2C4)[C@]6([H])[C@@]35[H] |c:5| Show InChI InChI=1S/C21H22N2O2/c24-18-10-16-19-13-9-17-21(6-7-22(17)11-12(13)5-8-25-16)14-3-1-2-4-15(14)23(18)20(19)21/h1-5,13,16-17,19-20H,6-11H2/t13-,16-,17-,19-,20-,21+/m0/s1 | PDB
UniProtKB/SwissProt
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| PDB Article PubMed
| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
The German University in Cairo
Curated by ChEMBL
| Assay Description Antagonist activity at human glycine receptor subunit alpha-1 expressed in human tsA201 cells assessed as reduction in glycine-induced response by fl... |
J Nat Prod 82: 2332-2336 (2019)
Article DOI: 10.1021/acs.jnatprod.9b00180 BindingDB Entry DOI: 10.7270/Q2571GB7 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Glycine receptor subunit alpha-1
(Homo sapiens (Human)) | BDBM50225707
(CHEBI:28973 | Strychnine)Show SMILES [H][C@]12C[C@@]3([H])C4=CCO[C@@]5([H])CC(=O)N6c7ccccc7[C@@]1(CCN2C4)[C@]6([H])[C@@]35[H] |c:5| Show InChI InChI=1S/C21H22N2O2/c24-18-10-16-19-13-9-17-21(6-7-22(17)11-12(13)5-8-25-16)14-3-1-2-4-15(14)23(18)20(19)21/h1-5,13,16-17,19-20H,6-11H2/t13-,16-,17-,19-,20-,21+/m0/s1 | PDB
UniProtKB/SwissProt
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| PDB Article PubMed
| n/a | n/a | 151 | n/a | n/a | n/a | n/a | n/a | n/a |
The German University in Cairo
Curated by ChEMBL
| Assay Description Antagonist activity at human glycine receptor subunit alpha-1 expressed in human tsA201 cells assessed as reduction in glycine-induced response by fl... |
J Nat Prod 82: 2332-2336 (2019)
Article DOI: 10.1021/acs.jnatprod.9b00180 BindingDB Entry DOI: 10.7270/Q2571GB7 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Glycine receptor subunit alpha-1/beta
(Homo sapiens (Human)) | BDBM50225707
(CHEBI:28973 | Strychnine)Show SMILES [H][C@]12C[C@@]3([H])C4=CCO[C@@]5([H])CC(=O)N6c7ccccc7[C@@]1(CCN2C4)[C@]6([H])[C@@]35[H] |c:5| Show InChI InChI=1S/C21H22N2O2/c24-18-10-16-19-13-9-17-21(6-7-22(17)11-12(13)5-8-25-16)14-3-1-2-4-15(14)23(18)20(19)21/h1-5,13,16-17,19-20H,6-11H2/t13-,16-,17-,19-,20-,21+/m0/s1 | PDB
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| n/a | n/a | 58 | n/a | n/a | n/a | n/a | n/a | n/a |
The German University in Cairo
Curated by ChEMBL
| Assay Description Antagonist activity at human glycine receptor subunit alpha-1beta expressed in HEK293 cells assessed as reduction in glycine-induced whole cell curre... |
J Nat Prod 82: 2332-2336 (2019)
Article DOI: 10.1021/acs.jnatprod.9b00180 BindingDB Entry DOI: 10.7270/Q2571GB7 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Glycine receptor subunit alpha-1
(Homo sapiens (Human)) | BDBM50225707
(CHEBI:28973 | Strychnine)Show SMILES [H][C@]12C[C@@]3([H])C4=CCO[C@@]5([H])CC(=O)N6c7ccccc7[C@@]1(CCN2C4)[C@]6([H])[C@@]35[H] |c:5| Show InChI InChI=1S/C21H22N2O2/c24-18-10-16-19-13-9-17-21(6-7-22(17)11-12(13)5-8-25-16)14-3-1-2-4-15(14)23(18)20(19)21/h1-5,13,16-17,19-20H,6-11H2/t13-,16-,17-,19-,20-,21+/m0/s1 | PDB
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| n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Antagonist activity at human glycine receptor subunit alpha-1 assessed as inhibition of glycine-induced current measured at the later state of compou... |
Citation and Details
Article DOI: 10.1021/acs.jnatprod.0c01030 BindingDB Entry DOI: 10.7270/Q2HH6PV6 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Glycine receptor subunit alpha-1/beta
(Homo sapiens (Human)) | BDBM50225707
(CHEBI:28973 | Strychnine)Show SMILES [H][C@]12C[C@@]3([H])C4=CCO[C@@]5([H])CC(=O)N6c7ccccc7[C@@]1(CCN2C4)[C@]6([H])[C@@]35[H] |c:5| Show InChI InChI=1S/C21H22N2O2/c24-18-10-16-19-13-9-17-21(6-7-22(17)11-12(13)5-8-25-16)14-3-1-2-4-15(14)23(18)20(19)21/h1-5,13,16-17,19-20H,6-11H2/t13-,16-,17-,19-,20-,21+/m0/s1 | PDB
UniProtKB/SwissProt
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| n/a | n/a | 510 | n/a | n/a | n/a | n/a | n/a | n/a |
The German University in Cairo
Curated by ChEMBL
| Assay Description Antagonist activity at human glycine receptor subunit alpha-1beta expressed in human tsA201 cells assessed as reduction in glycine-induced response b... |
J Nat Prod 82: 2332-2336 (2019)
Article DOI: 10.1021/acs.jnatprod.9b00180 BindingDB Entry DOI: 10.7270/Q2571GB7 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Glycine receptor subunit alpha-1/beta
(Homo sapiens (Human)) | BDBM50225707
(CHEBI:28973 | Strychnine)Show SMILES [H][C@]12C[C@@]3([H])C4=CCO[C@@]5([H])CC(=O)N6c7ccccc7[C@@]1(CCN2C4)[C@]6([H])[C@@]35[H] |c:5| Show InChI InChI=1S/C21H22N2O2/c24-18-10-16-19-13-9-17-21(6-7-22(17)11-12(13)5-8-25-16)14-3-1-2-4-15(14)23(18)20(19)21/h1-5,13,16-17,19-20H,6-11H2/t13-,16-,17-,19-,20-,21+/m0/s1 | PDB
UniProtKB/SwissProt
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| n/a | n/a | 513 | n/a | n/a | n/a | n/a | n/a | n/a |
The German University in Cairo
Curated by ChEMBL
| Assay Description Antagonist activity at human glycine receptor subunit alpha-1beta expressed in human tsA201 cells assessed as reduction in glycine-induced response b... |
J Nat Prod 82: 2332-2336 (2019)
Article DOI: 10.1021/acs.jnatprod.9b00180 BindingDB Entry DOI: 10.7270/Q2571GB7 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Glycine receptor subunit alpha-1
(Homo sapiens (Human)) | BDBM50225707
(CHEBI:28973 | Strychnine)Show SMILES [H][C@]12C[C@@]3([H])C4=CCO[C@@]5([H])CC(=O)N6c7ccccc7[C@@]1(CCN2C4)[C@]6([H])[C@@]35[H] |c:5| Show InChI InChI=1S/C21H22N2O2/c24-18-10-16-19-13-9-17-21(6-7-22(17)11-12(13)5-8-25-16)14-3-1-2-4-15(14)23(18)20(19)21/h1-5,13,16-17,19-20H,6-11H2/t13-,16-,17-,19-,20-,21+/m0/s1 | PDB
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| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Antagonist activity at human glycine receptor subunit alpha-1 expressed in human tsA201 cells assessed as reduction in glycine-induced response incub... |
Citation and Details
Article DOI: 10.1021/acs.jnatprod.0c01030 BindingDB Entry DOI: 10.7270/Q2HH6PV6 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Glycine receptor subunit alpha-1
(Homo sapiens (Human)) | BDBM50225707
(CHEBI:28973 | Strychnine)Show SMILES [H][C@]12C[C@@]3([H])C4=CCO[C@@]5([H])CC(=O)N6c7ccccc7[C@@]1(CCN2C4)[C@]6([H])[C@@]35[H] |c:5| Show InChI InChI=1S/C21H22N2O2/c24-18-10-16-19-13-9-17-21(6-7-22(17)11-12(13)5-8-25-16)14-3-1-2-4-15(14)23(18)20(19)21/h1-5,13,16-17,19-20H,6-11H2/t13-,16-,17-,19-,20-,21+/m0/s1 | PDB
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| n/a | n/a | 151 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Antagonist activity at human glycine receptor subunit alpha-1 expressed in human tsA201 cells assessed as reduction in glycine-induced response incub... |
Citation and Details
Article DOI: 10.1021/acs.jnatprod.0c01030 BindingDB Entry DOI: 10.7270/Q2HH6PV6 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Glycine receptor subunit alpha-1/beta
(Homo sapiens (Human)) | BDBM50225707
(CHEBI:28973 | Strychnine)Show SMILES [H][C@]12C[C@@]3([H])C4=CCO[C@@]5([H])CC(=O)N6c7ccccc7[C@@]1(CCN2C4)[C@]6([H])[C@@]35[H] |c:5| Show InChI InChI=1S/C21H22N2O2/c24-18-10-16-19-13-9-17-21(6-7-22(17)11-12(13)5-8-25-16)14-3-1-2-4-15(14)23(18)20(19)21/h1-5,13,16-17,19-20H,6-11H2/t13-,16-,17-,19-,20-,21+/m0/s1 | PDB
UniProtKB/SwissProt
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| n/a | n/a | 510 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Antagonist activity at human glycine receptor subunit alpha-1beta expressed in human tsA201 cells assessed as reduction in glycine-induced response i... |
Citation and Details
Article DOI: 10.1021/acs.jnatprod.0c01030 BindingDB Entry DOI: 10.7270/Q2HH6PV6 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Glycine receptor subunit alpha-1/beta
(Homo sapiens (Human)) | BDBM50225707
(CHEBI:28973 | Strychnine)Show SMILES [H][C@]12C[C@@]3([H])C4=CCO[C@@]5([H])CC(=O)N6c7ccccc7[C@@]1(CCN2C4)[C@]6([H])[C@@]35[H] |c:5| Show InChI InChI=1S/C21H22N2O2/c24-18-10-16-19-13-9-17-21(6-7-22(17)11-12(13)5-8-25-16)14-3-1-2-4-15(14)23(18)20(19)21/h1-5,13,16-17,19-20H,6-11H2/t13-,16-,17-,19-,20-,21+/m0/s1 | PDB
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| n/a | n/a | 513 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Antagonist activity at human glycine receptor subunit alpha-1beta expressed in human tsA201 cells assessed as reduction in glycine-induced response i... |
Citation and Details
Article DOI: 10.1021/acs.jnatprod.0c01030 BindingDB Entry DOI: 10.7270/Q2HH6PV6 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Glycine receptor subunit alpha-1
(Homo sapiens (Human)) | BDBM50225707
(CHEBI:28973 | Strychnine)Show SMILES [H][C@]12C[C@@]3([H])C4=CCO[C@@]5([H])CC(=O)N6c7ccccc7[C@@]1(CCN2C4)[C@]6([H])[C@@]35[H] |c:5| Show InChI InChI=1S/C21H22N2O2/c24-18-10-16-19-13-9-17-21(6-7-22(17)11-12(13)5-8-25-16)14-3-1-2-4-15(14)23(18)20(19)21/h1-5,13,16-17,19-20H,6-11H2/t13-,16-,17-,19-,20-,21+/m0/s1 | PDB
UniProtKB/SwissProt
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| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Antagonist activity at human glycine receptor subunit alpha-1 expressed in HEK293 cells assessed as reduction in glycine-induced currents by whole-ce... |
Citation and Details
Article DOI: 10.1021/acs.jnatprod.0c01030 BindingDB Entry DOI: 10.7270/Q2HH6PV6 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Glycine receptor subunit alpha-1/beta
(Homo sapiens (Human)) | BDBM50225707
(CHEBI:28973 | Strychnine)Show SMILES [H][C@]12C[C@@]3([H])C4=CCO[C@@]5([H])CC(=O)N6c7ccccc7[C@@]1(CCN2C4)[C@]6([H])[C@@]35[H] |c:5| Show InChI InChI=1S/C21H22N2O2/c24-18-10-16-19-13-9-17-21(6-7-22(17)11-12(13)5-8-25-16)14-3-1-2-4-15(14)23(18)20(19)21/h1-5,13,16-17,19-20H,6-11H2/t13-,16-,17-,19-,20-,21+/m0/s1 | PDB
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| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Antagonist activity at human glycine receptor subunit alpha-1beta expressed in HEK293 cells assessed as reduction in glycine-induced currents by whol... |
Citation and Details
Article DOI: 10.1021/acs.jnatprod.0c01030 BindingDB Entry DOI: 10.7270/Q2HH6PV6 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Glycine receptor subunit alpha-1
(Homo sapiens (Human)) | BDBM50225707
(CHEBI:28973 | Strychnine)Show SMILES [H][C@]12C[C@@]3([H])C4=CCO[C@@]5([H])CC(=O)N6c7ccccc7[C@@]1(CCN2C4)[C@]6([H])[C@@]35[H] |c:5| Show InChI InChI=1S/C21H22N2O2/c24-18-10-16-19-13-9-17-21(6-7-22(17)11-12(13)5-8-25-16)14-3-1-2-4-15(14)23(18)20(19)21/h1-5,13,16-17,19-20H,6-11H2/t13-,16-,17-,19-,20-,21+/m0/s1 | PDB
UniProtKB/SwissProt
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| PDB Article PubMed
| n/a | n/a | 134 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Antagonist activity at human glycine receptor subunit alpha-1 assessed as inhibition of glycine-induced current measured at the onset of compound app... |
Citation and Details
Article DOI: 10.1021/acs.jnatprod.0c01030 BindingDB Entry DOI: 10.7270/Q2HH6PV6 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Glycine receptor subunit alpha-1/beta
(Homo sapiens (Human)) | BDBM50225707
(CHEBI:28973 | Strychnine)Show SMILES [H][C@]12C[C@@]3([H])C4=CCO[C@@]5([H])CC(=O)N6c7ccccc7[C@@]1(CCN2C4)[C@]6([H])[C@@]35[H] |c:5| Show InChI InChI=1S/C21H22N2O2/c24-18-10-16-19-13-9-17-21(6-7-22(17)11-12(13)5-8-25-16)14-3-1-2-4-15(14)23(18)20(19)21/h1-5,13,16-17,19-20H,6-11H2/t13-,16-,17-,19-,20-,21+/m0/s1 | PDB
UniProtKB/SwissProt
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| PDB Article PubMed
| n/a | n/a | 58 | n/a | n/a | n/a | n/a | n/a | n/a |
The German University in Cairo
Curated by ChEMBL
| Assay Description Antagonist activity at recombinant human glycine receptor alpha 1 beta expressed in HEK293 cells assessed as inhibition of glycine-induced current at... |
J Nat Prod 79: 2997-3005 (2016)
Article DOI: 10.1021/acs.jnatprod.6b00479 BindingDB Entry DOI: 10.7270/Q2QZ2D66 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Glycine receptor subunit alpha-1/beta
(Homo sapiens (Human)) | BDBM50225707
(CHEBI:28973 | Strychnine)Show SMILES [H][C@]12C[C@@]3([H])C4=CCO[C@@]5([H])CC(=O)N6c7ccccc7[C@@]1(CCN2C4)[C@]6([H])[C@@]35[H] |c:5| Show InChI InChI=1S/C21H22N2O2/c24-18-10-16-19-13-9-17-21(6-7-22(17)11-12(13)5-8-25-16)14-3-1-2-4-15(14)23(18)20(19)21/h1-5,13,16-17,19-20H,6-11H2/t13-,16-,17-,19-,20-,21+/m0/s1 | PDB
UniProtKB/SwissProt
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KEGG PC cid PC sid PDB UniChem
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| n/a | n/a | 182 | n/a | n/a | n/a | n/a | n/a | n/a |
The German University in Cairo
Curated by ChEMBL
| Assay Description Antagonist activity at recombinant human glycine receptor alpha 1 beta expressed in human tsA201 cells assessed as inhibition of glycine-induced rece... |
J Nat Prod 79: 2997-3005 (2016)
Article DOI: 10.1021/acs.jnatprod.6b00479 BindingDB Entry DOI: 10.7270/Q2QZ2D66 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Glycine receptor subunit alpha-1
(Homo sapiens (Human)) | BDBM50225707
(CHEBI:28973 | Strychnine)Show SMILES [H][C@]12C[C@@]3([H])C4=CCO[C@@]5([H])CC(=O)N6c7ccccc7[C@@]1(CCN2C4)[C@]6([H])[C@@]35[H] |c:5| Show InChI InChI=1S/C21H22N2O2/c24-18-10-16-19-13-9-17-21(6-7-22(17)11-12(13)5-8-25-16)14-3-1-2-4-15(14)23(18)20(19)21/h1-5,13,16-17,19-20H,6-11H2/t13-,16-,17-,19-,20-,21+/m0/s1 | PDB
UniProtKB/SwissProt
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KEGG PC cid PC sid PDB UniChem
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| n/a | n/a | 51 | n/a | n/a | n/a | n/a | n/a | n/a |
The German University in Cairo
Curated by ChEMBL
| Assay Description Antagonist activity at recombinant human glycine receptor alpha 1 expressed in HEK293 cells assessed as inhibition of glycine-induced current at -50 ... |
J Nat Prod 79: 2997-3005 (2016)
Article DOI: 10.1021/acs.jnatprod.6b00479 BindingDB Entry DOI: 10.7270/Q2QZ2D66 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Sodium channel protein type 1/2/3 subunit alpha
(Homo sapiens (Human)) | BDBM50225707
(CHEBI:28973 | Strychnine)Show SMILES [H][C@]12C[C@@]3([H])C4=CCO[C@@]5([H])CC(=O)N6c7ccccc7[C@@]1(CCN2C4)[C@]6([H])[C@@]35[H] |c:5| Show InChI InChI=1S/C21H22N2O2/c24-18-10-16-19-13-9-17-21(6-7-22(17)11-12(13)5-8-25-16)14-3-1-2-4-15(14)23(18)20(19)21/h1-5,13,16-17,19-20H,6-11H2/t13-,16-,17-,19-,20-,21+/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
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| n/a | n/a | 2.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of binding of Batrachotoxinin [3H]BTX-B to high affinity sites on voltage dependent sodium channels in a vesicular preparation from guinea... |
J Med Chem 28: 381-8 (1985)
BindingDB Entry DOI: 10.7270/Q2Z321T8 |
More data for this Ligand-Target Pair | |
Glycine receptor subunit alpha-1
(Homo sapiens (Human)) | BDBM50225707
(CHEBI:28973 | Strychnine)Show SMILES [H][C@]12C[C@@]3([H])C4=CCO[C@@]5([H])CC(=O)N6c7ccccc7[C@@]1(CCN2C4)[C@]6([H])[C@@]35[H] |c:5| Show InChI InChI=1S/C21H22N2O2/c24-18-10-16-19-13-9-17-21(6-7-22(17)11-12(13)5-8-25-16)14-3-1-2-4-15(14)23(18)20(19)21/h1-5,13,16-17,19-20H,6-11H2/t13-,16-,17-,19-,20-,21+/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
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KEGG PC cid PC sid PDB UniChem
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| PDB Article PubMed
| n/a | n/a | 51 | n/a | n/a | n/a | n/a | n/a | n/a |
The German University in Cairo
Curated by ChEMBL
| Assay Description Antagonist activity at human glycine receptor subunit alpha-1 expressed in HEK293 cells assessed as reduction in glycine-induced whole cell currents ... |
J Nat Prod 82: 2332-2336 (2019)
Article DOI: 10.1021/acs.jnatprod.9b00180 BindingDB Entry DOI: 10.7270/Q2571GB7 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |