BindingDB PrimarySearch

BDBM50226008 (R)-3-(4-propylmorpholin-2-yl)phenol::CHEMBL250403

SMILES: CCCN1CCO[C@@H](C1)c1cccc(O)c1

InChI Key: InChIKey=WYEGTIGJSHGEID-ZDUSSCGKSA-N

Data: 6 KI 3 IC50 2 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50226008
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
5-hydroxytryptamine receptor 2A (Rattus norvegicus (rat))	BDBM50226008 ((R)-3-(4-propylmorpholin-2-yl)phenol \| CHEMBL25040...) Show SMILES CCCN1CCO[C@@H](C1)c1cccc(O)c1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	970	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research & Development Curated by ChEMBL					Assay Description Binding affinity to rat 5HT2A receptor				Bioorg Med Chem Lett 17: 6691-6 (2007) Article DOI: 10.1016/j.bmcl.2007.10.059 BindingDB Entry DOI: 10.7270/Q23J3CQ5
Pfizer Global Research & Development Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-1A adrenergic receptor (Rattus norvegicus (Rat))	BDBM50226008 ((R)-3-(4-propylmorpholin-2-yl)phenol \| CHEMBL25040...) Show SMILES CCCN1CCO[C@@H](C1)c1cccc(O)c1 Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research & Development Curated by ChEMBL					Assay Description Binding affinity to rat alpha1A adrenergic receptor				Bioorg Med Chem Lett 17: 6691-6 (2007) Article DOI: 10.1016/j.bmcl.2007.10.059 BindingDB Entry DOI: 10.7270/Q23J3CQ5
Pfizer Global Research & Development Curated by ChEMBL					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50226008 ((R)-3-(4-propylmorpholin-2-yl)phenol \| CHEMBL25040...) Show SMILES CCCN1CCO[C@@H](C1)c1cccc(O)c1 Show InChI	UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research & Development Curated by ChEMBL					Assay Description Binding affinity to human muscarinic M1 receptor				Bioorg Med Chem Lett 17: 6691-6 (2007) Article DOI: 10.1016/j.bmcl.2007.10.059 BindingDB Entry DOI: 10.7270/Q23J3CQ5
Pfizer Global Research & Development Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-2A adrenergic receptor (Homo sapiens (Human))	BDBM50226008 ((R)-3-(4-propylmorpholin-2-yl)phenol \| CHEMBL25040...) Show SMILES CCCN1CCO[C@@H](C1)c1cccc(O)c1 Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research & Development Curated by ChEMBL					Assay Description Binding affinity to human alpha2A adrenergic receptor				Bioorg Med Chem Lett 17: 6691-6 (2007) Article DOI: 10.1016/j.bmcl.2007.10.059 BindingDB Entry DOI: 10.7270/Q23J3CQ5
Pfizer Global Research & Development Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H1 receptor (Homo sapiens (Human))	BDBM50226008 ((R)-3-(4-propylmorpholin-2-yl)phenol \| CHEMBL25040...) Show SMILES CCCN1CCO[C@@H](C1)c1cccc(O)c1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	>2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research & Development Curated by ChEMBL					Assay Description Binding affinity to human histamine H1 receptor				Bioorg Med Chem Lett 17: 6691-6 (2007) Article DOI: 10.1016/j.bmcl.2007.10.059 BindingDB Entry DOI: 10.7270/Q23J3CQ5
Pfizer Global Research & Development Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50226008 ((R)-3-(4-propylmorpholin-2-yl)phenol \| CHEMBL25040...) Show SMILES CCCN1CCO[C@@H](C1)c1cccc(O)c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	>4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research & Development Curated by ChEMBL					Assay Description Displacement of dofetilide from hERG				Bioorg Med Chem Lett 17: 6691-6 (2007) Article DOI: 10.1016/j.bmcl.2007.10.059 BindingDB Entry DOI: 10.7270/Q23J3CQ5
Pfizer Global Research & Development Curated by ChEMBL					More data for this Ligand-Target Pair
D(3) dopamine receptor (Homo sapiens (Human))	BDBM50226008 ((R)-3-(4-propylmorpholin-2-yl)phenol \| CHEMBL25040...) Show SMILES CCCN1CCO[C@@H](C1)c1cccc(O)c1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	8	n/a	n/a	n/a	n/a
Pfizer Global Research & Development Curated by ChEMBL					Assay Description Agonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation				Bioorg Med Chem Lett 17: 6691-6 (2007) Article DOI: 10.1016/j.bmcl.2007.10.059 BindingDB Entry DOI: 10.7270/Q23J3CQ5
Pfizer Global Research & Development Curated by ChEMBL					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50226008 ((R)-3-(4-propylmorpholin-2-yl)phenol \| CHEMBL25040...) Show SMILES CCCN1CCO[C@@H](C1)c1cccc(O)c1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
Pfizer Global Research & Development Curated by ChEMBL					Assay Description Agonist activity at human recombinant dopamine D2 receptor expressed in rat pituitary cells assessed as inhibition of forskolin-stimulated cAMP accum...				Bioorg Med Chem Lett 17: 6691-6 (2007) Article DOI: 10.1016/j.bmcl.2007.10.059 BindingDB Entry DOI: 10.7270/Q23J3CQ5
Pfizer Global Research & Development Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Homo sapiens (Human))	BDBM50226008 ((R)-3-(4-propylmorpholin-2-yl)phenol \| CHEMBL25040...) Show SMILES CCCN1CCO[C@@H](C1)c1cccc(O)c1 Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research & Development Curated by ChEMBL					Assay Description Antagonist activity at human recombinant 5HT1A receptor				Bioorg Med Chem Lett 17: 6691-6 (2007) Article DOI: 10.1016/j.bmcl.2007.10.059 BindingDB Entry DOI: 10.7270/Q23J3CQ5
Pfizer Global Research & Development Curated by ChEMBL					More data for this Ligand-Target Pair
D(1B) dopamine receptor (Homo sapiens (Human))	BDBM50226008 ((R)-3-(4-propylmorpholin-2-yl)phenol \| CHEMBL25040...) Show SMILES CCCN1CCO[C@@H](C1)c1cccc(O)c1 Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research & Development Curated by ChEMBL					Assay Description Binding affinity to dopamine D5 receptor				Bioorg Med Chem Lett 17: 6691-6 (2007) Article DOI: 10.1016/j.bmcl.2007.10.059 BindingDB Entry DOI: 10.7270/Q23J3CQ5
Pfizer Global Research & Development Curated by ChEMBL					More data for this Ligand-Target Pair
D(1A) dopamine receptor (Homo sapiens (Human))	BDBM50226008 ((R)-3-(4-propylmorpholin-2-yl)phenol \| CHEMBL25040...) Show SMILES CCCN1CCO[C@@H](C1)c1cccc(O)c1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research & Development Curated by ChEMBL					Assay Description Binding affinity to dopamine D1 receptor				Bioorg Med Chem Lett 17: 6691-6 (2007) Article DOI: 10.1016/j.bmcl.2007.10.059 BindingDB Entry DOI: 10.7270/Q23J3CQ5
Pfizer Global Research & Development Curated by ChEMBL					More data for this Ligand-Target Pair