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SMILES: COc1c(Cl)nc(nc1NC1CCCC1)N1CCN(C)CC1

InChI Key: InChIKey=ILJZSVIOWUNDKO-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50226327   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor (RAT-NEONATAL RAT-Rattus norvegicus (rat))	BDBM50226327 (CHEMBL283076) Show SMILES COc1c(Cl)nc(nc1NC1CCCC1)N1CCN(C)CC1 Show InChI InChI=1S/C15H24ClN5O/c1-20-7-9-21(10-8-20)15-18-13(16)12(22-2)14(19-15)17-11-5-3-4-6-11/h11H,3-10H2,1-2H3,(H,17,18,19)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	29	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of [3H]idazoxan binding to alpha-2 adrenergic receptor of rat cortical membranes				J Med Chem 29: 1394-8 (1986) BindingDB Entry DOI: 10.7270/Q21R6SQQ
					More data for this Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor (RAT-NEONATAL RAT-Rattus norvegicus (rat))	BDBM50226327 (CHEMBL283076) Show SMILES COc1c(Cl)nc(nc1NC1CCCC1)N1CCN(C)CC1 Show InChI InChI=1S/C15H24ClN5O/c1-20-7-9-21(10-8-20)15-18-13(16)12(22-2)14(19-15)17-11-5-3-4-6-11/h11H,3-10H2,1-2H3,(H,17,18,19)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	50	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description In vitro binding affinity was measured as the inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor of rat cortical membranes				J Med Chem 29: 1394-8 (1986) BindingDB Entry DOI: 10.7270/Q21R6SQQ
					More data for this Ligand-Target Pair
D(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor (Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)	BDBM50226327 (CHEMBL283076) Show SMILES COc1c(Cl)nc(nc1NC1CCCC1)N1CCN(C)CC1 Show InChI InChI=1S/C15H24ClN5O/c1-20-7-9-21(10-8-20)15-18-13(16)12(22-2)14(19-15)17-11-5-3-4-6-11/h11H,3-10H2,1-2H3,(H,17,18,19)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	670	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description In vitro binding affinity to Dopamine receptors of rat striatal membranes by [3H]spiroperidol displacement.				J Med Chem 29: 1394-8 (1986) BindingDB Entry DOI: 10.7270/Q21R6SQQ
					More data for this Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM50226327 (CHEMBL283076) Show SMILES COc1c(Cl)nc(nc1NC1CCCC1)N1CCN(C)CC1 Show InChI InChI=1S/C15H24ClN5O/c1-20-7-9-21(10-8-20)15-18-13(16)12(22-2)14(19-15)17-11-5-3-4-6-11/h11H,3-10H2,1-2H3,(H,17,18,19)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	1.70E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description In vitro binding affinity was measured as the inhibition of [3H]WB-4101 binding to alpha-1 adrenergic receptor of rat cortical membranes				J Med Chem 29: 1394-8 (1986) BindingDB Entry DOI: 10.7270/Q21R6SQQ
					More data for this Ligand-Target Pair