BDBM50227494 CHEMBL257286::N-(quinolin-8-yl)benzenesulfonamide::N-Quinolin-8-yl-benzenesulfonamide::cid_161167

SMILES: O=S(=O)(Nc1cccc2cccnc12)c1ccccc1

InChI Key: InChIKey=FEBBZFJWAMUFPI-UHFFFAOYSA-N

Data: 10 IC50  4 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50227494   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
nucleotide-binding oligomerization domain containing 2 (Homo sapiens (Human))	BDBM50227494 (CHEMBL257286 | N-(quinolin-8-yl)benzenesulfonamide...) Show SMILES O=S(=O)(Nc1cccc2cccnc12)c1ccccc1 Show InChI InChI=1S/C15H12N2O2S/c18-20(19,13-8-2-1-3-9-13)17-14-10-4-6-12-7-5-11-16-15(12)14/h1-11,17H	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PCBioAssay	n/a	n/a	1.83E+3	n/a	n/a	n/a	n/a	n/a	n/a
Burnham Center for Chemical Genomics Curated by PubChem BioAssay					Assay Description Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...				PubChem Bioassay (2010) BindingDB Entry DOI: 10.7270/Q23R0R8T
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streptokinase A precursor (Streptococcus pyogenes M1 GAS)	BDBM50227494 (CHEMBL257286 | N-(quinolin-8-yl)benzenesulfonamide...) Show SMILES O=S(=O)(Nc1cccc2cccnc12)c1ccccc1 Show InChI InChI=1S/C15H12N2O2S/c18-20(19,13-8-2-1-3-9-13)17-14-10-4-6-12-7-5-11-16-15(12)14/h1-11,17H	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PCBioAssay	n/a	n/a	n/a	n/a	1.50E+5	n/a	n/a	n/a	n/a
Broad Institute Curated by PubChem BioAssay					Assay Description Keywords: Group A streptococcus, GAS, streptokinase, expression, virulence, inhibition, dose response, EC50 Assay Overview: The goal of this assa...				PubChem Bioassay (2009) BindingDB Entry DOI: 10.7270/Q2736PBV
					More data for this Ligand-Target Pair
nucleotide-binding oligomerization domain containing 1 (Homo sapiens (Human))	BDBM50227494 (CHEMBL257286 | N-(quinolin-8-yl)benzenesulfonamide...) Show SMILES O=S(=O)(Nc1cccc2cccnc12)c1ccccc1 Show InChI InChI=1S/C15H12N2O2S/c18-20(19,13-8-2-1-3-9-13)17-14-10-4-6-12-7-5-11-16-15(12)14/h1-11,17H	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PCBioAssay	n/a	n/a	n/a	n/a	2.00E+4	n/a	n/a	n/a	n/a
Burnham Center for Chemical Genomics Curated by PubChem BioAssay					Assay Description Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...				PubChem Bioassay (2010) BindingDB Entry DOI: 10.7270/Q2CN72C0
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Tumor necrosis factor (Homo sapiens (Human))	BDBM50227494 (CHEMBL257286 | N-(quinolin-8-yl)benzenesulfonamide...) Show SMILES O=S(=O)(Nc1cccc2cccnc12)c1ccccc1 Show InChI InChI=1S/C15H12N2O2S/c18-20(19,13-8-2-1-3-9-13)17-14-10-4-6-12-7-5-11-16-15(12)14/h1-11,17H	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PCBioAssay	n/a	n/a	2.74E+3	n/a	n/a	n/a	n/a	n/a	n/a
Burnham Center for Chemical Genomics Curated by PubChem BioAssay					Assay Description Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...				PubChem Bioassay (2010) BindingDB Entry DOI: 10.7270/Q25M6443
					More data for this Ligand-Target Pair
Apelin receptor (Homo sapiens (Human))	BDBM50227494 (CHEMBL257286 | N-(quinolin-8-yl)benzenesulfonamide...) Show SMILES O=S(=O)(Nc1cccc2cccnc12)c1ccccc1 Show InChI InChI=1S/C15H12N2O2S/c18-20(19,13-8-2-1-3-9-13)17-14-10-4-6-12-7-5-11-16-15(12)14/h1-11,17H	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PCBioAssay	n/a	n/a	3.55E+4	n/a	n/a	n/a	n/a	n/a	n/a
Sanford-Burnham Center for Chemical Genomics Curated by PubChem BioAssay					Assay Description Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford- Sanford-Burnham Medical Research Institute(SBMRI, San...				PubChem Bioassay (2010) BindingDB Entry DOI: 10.7270/Q2MK6BBZ
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Angiotensin II receptor (Homo sapiens (Human))	BDBM50227494 (CHEMBL257286 | N-(quinolin-8-yl)benzenesulfonamide...) Show SMILES O=S(=O)(Nc1cccc2cccnc12)c1ccccc1 Show InChI InChI=1S/C15H12N2O2S/c18-20(19,13-8-2-1-3-9-13)17-14-10-4-6-12-7-5-11-16-15(12)14/h1-11,17H	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PCBioAssay	n/a	n/a	2.75E+3	n/a	n/a	n/a	n/a	n/a	n/a
Burnham Center for Chemical Genomics Curated by PubChem BioAssay					Assay Description Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute(SBMRI, San Diego, C...				PubChem Bioassay (2010) BindingDB Entry DOI: 10.7270/Q2CJ8BXT
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Glyoxalase I (Homo sapiens (Human))	BDBM50227494 (CHEMBL257286 | N-(quinolin-8-yl)benzenesulfonamide...) Show SMILES O=S(=O)(Nc1cccc2cccnc12)c1ccccc1 Show InChI InChI=1S/C15H12N2O2S/c18-20(19,13-8-2-1-3-9-13)17-14-10-4-6-12-7-5-11-16-15(12)14/h1-11,17H	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	8.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition recombinant human N-terminal 6His-tagged GLO1 (2 to 184 residues) expressed in Escherichia coli using MG as substrate preincubated for 15 ...				J Med Chem 62: 1609-1625 (2019) Article DOI: 10.1021/acs.jmedchem.8b01868
					More data for this Ligand-Target Pair
Nuclear factor NF-kappa-B (Homo sapiens (Human))	BDBM50227494 (CHEMBL257286 | N-(quinolin-8-yl)benzenesulfonamide...) Show SMILES O=S(=O)(Nc1cccc2cccnc12)c1ccccc1 Show InChI InChI=1S/C15H12N2O2S/c18-20(19,13-8-2-1-3-9-13)17-14-10-4-6-12-7-5-11-16-15(12)14/h1-11,17H	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Columbia University Curated by ChEMBL					Assay Description Inhibition of TNF-alpha-stimulated human NF-kappaB p65 RelA subunit nuclear translocation in HUVEC				Bioorg Med Chem Lett 18: 329-35 (2008) Article DOI: 10.1016/j.bmcl.2007.10.100 BindingDB Entry DOI: 10.7270/Q2348M63
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I-kappa-B-alpha (Homo sapiens (Human))	BDBM50227494 (CHEMBL257286 | N-(quinolin-8-yl)benzenesulfonamide...) Show SMILES O=S(=O)(Nc1cccc2cccnc12)c1ccccc1 Show InChI InChI=1S/C15H12N2O2S/c18-20(19,13-8-2-1-3-9-13)17-14-10-4-6-12-7-5-11-16-15(12)14/h1-11,17H	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1.70E+4	n/a	n/a	n/a	n/a
Columbia University Curated by ChEMBL					Assay Description Induction of human IkappaBalpha stabilization in OCI-Ly3 cells by green light emiting IkappaBalpha-fused luciferase reporter gene assay				Bioorg Med Chem Lett 18: 329-35 (2008) Article DOI: 10.1016/j.bmcl.2007.10.100 BindingDB Entry DOI: 10.7270/Q2348M63
					More data for this Ligand-Target Pair
I-kappa-B-alpha (Homo sapiens (Human))	BDBM50227494 (CHEMBL257286 | N-(quinolin-8-yl)benzenesulfonamide...) Show SMILES O=S(=O)(Nc1cccc2cccnc12)c1ccccc1 Show InChI InChI=1S/C15H12N2O2S/c18-20(19,13-8-2-1-3-9-13)17-14-10-4-6-12-7-5-11-16-15(12)14/h1-11,17H	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	2.00E+4	n/a	n/a	n/a	n/a
Columbia University Curated by ChEMBL					Assay Description Induction of human IkappaBalpha stabilization in OCI-Ly3 cells assessed as ratio of green light emiting IkappaBalpha-fused luciferase expression to r...				Bioorg Med Chem Lett 18: 329-35 (2008) Article DOI: 10.1016/j.bmcl.2007.10.100 BindingDB Entry DOI: 10.7270/Q2348M63
					More data for this Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1) (Homo sapiens (Human))	BDBM50227494 (CHEMBL257286 | N-(quinolin-8-yl)benzenesulfonamide...) Show SMILES O=S(=O)(Nc1cccc2cccnc12)c1ccccc1 Show InChI InChI=1S/C15H12N2O2S/c18-20(19,13-8-2-1-3-9-13)17-14-10-4-6-12-7-5-11-16-15(12)14/h1-11,17H	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.49E+4	n/a	n/a	n/a	n/a	n/a	n/a
Universit£t Heidelberg Curated by ChEMBL					Assay Description Inhibition of human MetAP1				Bioorg Med Chem Lett 20: 4038-44 (2010) Article DOI: 10.1016/j.bmcl.2010.05.093 BindingDB Entry DOI: 10.7270/Q2RF5W0K
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Methionine aminopeptidase 2 (Homo sapiens (Human))	BDBM50227494 (CHEMBL257286 | N-(quinolin-8-yl)benzenesulfonamide...) Show SMILES O=S(=O)(Nc1cccc2cccnc12)c1ccccc1 Show InChI InChI=1S/C15H12N2O2S/c18-20(19,13-8-2-1-3-9-13)17-14-10-4-6-12-7-5-11-16-15(12)14/h1-11,17H	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.98E+4	n/a	n/a	n/a	n/a	n/a	n/a
Universit£t Heidelberg Curated by ChEMBL					Assay Description Inhibition of human MetAP2 expressed in baculovirus infected Sf9 cells				Bioorg Med Chem Lett 20: 4038-44 (2010) Article DOI: 10.1016/j.bmcl.2010.05.093 BindingDB Entry DOI: 10.7270/Q2RF5W0K
					More data for this Ligand-Target Pair
Beta-glucuronidase (Bos taurus (Bovine))	BDBM50227494 (CHEMBL257286 | N-(quinolin-8-yl)benzenesulfonamide...) Show SMILES O=S(=O)(Nc1cccc2cccnc12)c1ccccc1 Show InChI InChI=1S/C15H12N2O2S/c18-20(19,13-8-2-1-3-9-13)17-14-10-4-6-12-7-5-11-16-15(12)14/h1-11,17H	KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6.64E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Karachi Curated by ChEMBL					Assay Description Antagonistic activity for inhibition of histamine H2 receptor from anesthetized rats				Eur J Med Chem 139: 849-864 (2017) Article DOI: 10.1016/j.ejmech.2017.08.052 BindingDB Entry DOI: 10.7270/Q20P12HF
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endothelial PAS domain-containing protein 1 (Homo sapiens (Human))	BDBM50227494 (CHEMBL257286 | N-(quinolin-8-yl)benzenesulfonamide...) Show SMILES O=S(=O)(Nc1cccc2cccnc12)c1ccccc1 Show InChI InChI=1S/C15H12N2O2S/c18-20(19,13-8-2-1-3-9-13)17-14-10-4-6-12-7-5-11-16-15(12)14/h1-11,17H	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PCBioAssay	n/a	n/a	3.37E+3	n/a	n/a	n/a	n/a	n/a	n/a
Burnham Center for Chemical Genomics Curated by PubChem BioAssay									PubChem Bioassay (2012) BindingDB Entry DOI: 10.7270/Q2WS8RVZ
					More data for this Ligand-Target Pair