Found 6 hits for monomerid = 50227990 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Disintegrin and metalloproteinase domain-containing protein 10 (ADAM10)
(Homo sapiens (Human)) | BDBM50227990
((6S,7S)-6-[4-(4-cyano-3,5-dimethyl-phenyl)-3,6-dih...)Show SMILES Cc1cc(cc(C)c1C#N)C1=CCN(CC1)C(=O)[C@H]1NCC2(CC2)C[C@@H]1C(=O)NO |t:11| Show InChI InChI=1S/C23H28N4O3/c1-14-9-17(10-15(2)19(14)12-24)16-3-7-27(8-4-16)22(29)20-18(21(28)26-30)11-23(5-6-23)13-25-20/h3,9-10,18,20,25,30H,4-8,11,13H2,1-2H3,(H,26,28)/t18-,20-/m0/s1 | PDB
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation
Curated by ChEMBL
| Assay Description Binding affinity to ADAM10 |
Bioorg Med Chem Lett 18: 159-63 (2008)
Article DOI: 10.1016/j.bmcl.2007.10.108 BindingDB Entry DOI: 10.7270/Q2GM8720 |
More data for this Ligand-Target Pair | |
Matrix metalloproteinase-9
(Homo sapiens (Human)) | BDBM50227990
((6S,7S)-6-[4-(4-cyano-3,5-dimethyl-phenyl)-3,6-dih...)Show SMILES Cc1cc(cc(C)c1C#N)C1=CCN(CC1)C(=O)[C@H]1NCC2(CC2)C[C@@H]1C(=O)NO |t:11| Show InChI InChI=1S/C23H28N4O3/c1-14-9-17(10-15(2)19(14)12-24)16-3-7-27(8-4-16)22(29)20-18(21(28)26-30)11-23(5-6-23)13-25-20/h3,9-10,18,20,25,30H,4-8,11,13H2,1-2H3,(H,26,28)/t18-,20-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation
Curated by ChEMBL
| Assay Description Binding affinity to MMP9 |
Bioorg Med Chem Lett 18: 159-63 (2008)
Article DOI: 10.1016/j.bmcl.2007.10.108 BindingDB Entry DOI: 10.7270/Q2GM8720 |
More data for this Ligand-Target Pair | |
Disintegrin and metalloproteinase domain-containing protein 10 (ADAM10)
(Homo sapiens (Human)) | BDBM50227990
((6S,7S)-6-[4-(4-cyano-3,5-dimethyl-phenyl)-3,6-dih...)Show SMILES Cc1cc(cc(C)c1C#N)C1=CCN(CC1)C(=O)[C@H]1NCC2(CC2)C[C@@H]1C(=O)NO |t:11| Show InChI InChI=1S/C23H28N4O3/c1-14-9-17(10-15(2)19(14)12-24)16-3-7-27(8-4-16)22(29)20-18(21(28)26-30)11-23(5-6-23)13-25-20/h3,9-10,18,20,25,30H,4-8,11,13H2,1-2H3,(H,26,28)/t18-,20-/m0/s1 | PDB
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 129 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation
Curated by ChEMBL
| Assay Description Inhibition of HER2 sheddase in BT474 cells by extracellular domain shedding assay |
Bioorg Med Chem Lett 18: 159-63 (2008)
Article DOI: 10.1016/j.bmcl.2007.10.108 BindingDB Entry DOI: 10.7270/Q2GM8720 |
More data for this Ligand-Target Pair | |
Stromelysin-1
(Homo sapiens (Human)) | BDBM50227990
((6S,7S)-6-[4-(4-cyano-3,5-dimethyl-phenyl)-3,6-dih...)Show SMILES Cc1cc(cc(C)c1C#N)C1=CCN(CC1)C(=O)[C@H]1NCC2(CC2)C[C@@H]1C(=O)NO |t:11| Show InChI InChI=1S/C23H28N4O3/c1-14-9-17(10-15(2)19(14)12-24)16-3-7-27(8-4-16)22(29)20-18(21(28)26-30)11-23(5-6-23)13-25-20/h3,9-10,18,20,25,30H,4-8,11,13H2,1-2H3,(H,26,28)/t18-,20-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation
Curated by ChEMBL
| Assay Description Binding affinity to MMP3 |
Bioorg Med Chem Lett 18: 159-63 (2008)
Article DOI: 10.1016/j.bmcl.2007.10.108 BindingDB Entry DOI: 10.7270/Q2GM8720 |
More data for this Ligand-Target Pair | |
Interstitial collagenase
(Homo sapiens (Human)) | BDBM50227990
((6S,7S)-6-[4-(4-cyano-3,5-dimethyl-phenyl)-3,6-dih...)Show SMILES Cc1cc(cc(C)c1C#N)C1=CCN(CC1)C(=O)[C@H]1NCC2(CC2)C[C@@H]1C(=O)NO |t:11| Show InChI InChI=1S/C23H28N4O3/c1-14-9-17(10-15(2)19(14)12-24)16-3-7-27(8-4-16)22(29)20-18(21(28)26-30)11-23(5-6-23)13-25-20/h3,9-10,18,20,25,30H,4-8,11,13H2,1-2H3,(H,26,28)/t18-,20-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation
Curated by ChEMBL
| Assay Description Binding affinity to MMP1 |
Bioorg Med Chem Lett 18: 159-63 (2008)
Article DOI: 10.1016/j.bmcl.2007.10.108 BindingDB Entry DOI: 10.7270/Q2GM8720 |
More data for this Ligand-Target Pair | |
72 kDa type IV collagenase
(Homo sapiens (Human)) | BDBM50227990
((6S,7S)-6-[4-(4-cyano-3,5-dimethyl-phenyl)-3,6-dih...)Show SMILES Cc1cc(cc(C)c1C#N)C1=CCN(CC1)C(=O)[C@H]1NCC2(CC2)C[C@@H]1C(=O)NO |t:11| Show InChI InChI=1S/C23H28N4O3/c1-14-9-17(10-15(2)19(14)12-24)16-3-7-27(8-4-16)22(29)20-18(21(28)26-30)11-23(5-6-23)13-25-20/h3,9-10,18,20,25,30H,4-8,11,13H2,1-2H3,(H,26,28)/t18-,20-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 159 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation
Curated by ChEMBL
| Assay Description Binding affinity to MMP2 |
Bioorg Med Chem Lett 18: 159-63 (2008)
Article DOI: 10.1016/j.bmcl.2007.10.108 BindingDB Entry DOI: 10.7270/Q2GM8720 |
More data for this Ligand-Target Pair | |