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SMILES: CCC(C)(C)C(=O)N(O)Cc1ccc(F)c(F)c1F

InChI Key: InChIKey=YFBROXMJBRPJKH-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50228871   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))		BDBM50228871
PNG
(CHEMBL4099502)
Show SMILES CCC(C)(C)C(=O)N(O)Cc1ccc(F)c(F)c1F
Show InChI InChI=1S/C13H16F3NO2/c1-4-13(2,3)12(18)17(19)7-8-5-6-9(14)11(16)10(8)15/h5-6,19H,4,7H2,1-3H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
MMDB
PC cid
PC sid
UniChem
PubMed
n/an/an/an/a 262n/an/an/an/a



National Institute of Biological Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...

J Med Chem 60: 972-986 (2017)


BindingDB Entry DOI: 10.7270/Q2QC05QD
More data for this
Ligand-Target Pair