BDBM50229220 CHEMBL254744::N-(4-(methylsulfonamido)benzyl)-4-methyl-2-(4-(trifluoromethyl)phenyl)thiazole-5-carboxamide

SMILES: Cc1nc(sc1C(=O)NCc1ccc(NS(C)(=O)=O)cc1)-c1ccc(cc1)C(F)(F)F

InChI Key: InChIKey=BIHNWTMNUQSVRZ-UHFFFAOYSA-N

Data: 6 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50229220   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Peroxisome proliferator-activated receptor alpha (PPAR alpha) (Homo sapiens (Human))	BDBM50229220 (CHEMBL254744 | N-(4-(methylsulfonamido)benzyl)-4-m...) Show SMILES Cc1nc(sc1C(=O)NCc1ccc(NS(C)(=O)=O)cc1)-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C20H18F3N3O3S2/c1-12-17(30-19(25-12)14-5-7-15(8-6-14)20(21,22)23)18(27)24-11-13-3-9-16(10-4-13)26-31(2,28)29/h3-10,26H,11H2,1-2H3,(H,24,27)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	60	n/a	n/a	n/a	n/a
Centre de Recherches Curated by ChEMBL					Assay Description Agonist activity at human PPARalpha assessed as receptor activation by cell based assay				Bioorg Med Chem Lett 18: 710-5 (2008) Article DOI: 10.1016/j.bmcl.2007.11.053 BindingDB Entry DOI: 10.7270/Q2542NBN
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Mus musculus)	BDBM50229220 (CHEMBL254744 | N-(4-(methylsulfonamido)benzyl)-4-m...) Show SMILES Cc1nc(sc1C(=O)NCc1ccc(NS(C)(=O)=O)cc1)-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C20H18F3N3O3S2/c1-12-17(30-19(25-12)14-5-7-15(8-6-14)20(21,22)23)18(27)24-11-13-3-9-16(10-4-13)26-31(2,28)29/h3-10,26H,11H2,1-2H3,(H,24,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	800	n/a	n/a	n/a	n/a
Centre de Recherches Curated by ChEMBL					Assay Description Agonist activity at mouse PPARalpha assessed as receptor activation by cell based assay				Bioorg Med Chem Lett 18: 710-5 (2008) Article DOI: 10.1016/j.bmcl.2007.11.053 BindingDB Entry DOI: 10.7270/Q2542NBN
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor gamma (Mus musculus)	BDBM50229220 (CHEMBL254744 | N-(4-(methylsulfonamido)benzyl)-4-m...) Show SMILES Cc1nc(sc1C(=O)NCc1ccc(NS(C)(=O)=O)cc1)-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C20H18F3N3O3S2/c1-12-17(30-19(25-12)14-5-7-15(8-6-14)20(21,22)23)18(27)24-11-13-3-9-16(10-4-13)26-31(2,28)29/h3-10,26H,11H2,1-2H3,(H,24,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
Centre de Recherches Curated by ChEMBL					Assay Description Agonist activity at mouse PPARgamma assessed as receptor activation by cell based assay				Bioorg Med Chem Lett 18: 710-5 (2008) Article DOI: 10.1016/j.bmcl.2007.11.053 BindingDB Entry DOI: 10.7270/Q2542NBN
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor (Homo sapiens (Human))	BDBM50229220 (CHEMBL254744 | N-(4-(methylsulfonamido)benzyl)-4-m...) Show SMILES Cc1nc(sc1C(=O)NCc1ccc(NS(C)(=O)=O)cc1)-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C20H18F3N3O3S2/c1-12-17(30-19(25-12)14-5-7-15(8-6-14)20(21,22)23)18(27)24-11-13-3-9-16(10-4-13)26-31(2,28)29/h3-10,26H,11H2,1-2H3,(H,24,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
Centre de Recherches Curated by ChEMBL					Assay Description Agonist activity at human PPARgamma assessed as receptor activation by cell based assay				Bioorg Med Chem Lett 18: 710-5 (2008) Article DOI: 10.1016/j.bmcl.2007.11.053 BindingDB Entry DOI: 10.7270/Q2542NBN
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (Mus musculus)	BDBM50229220 (CHEMBL254744 | N-(4-(methylsulfonamido)benzyl)-4-m...) Show SMILES Cc1nc(sc1C(=O)NCc1ccc(NS(C)(=O)=O)cc1)-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C20H18F3N3O3S2/c1-12-17(30-19(25-12)14-5-7-15(8-6-14)20(21,22)23)18(27)24-11-13-3-9-16(10-4-13)26-31(2,28)29/h3-10,26H,11H2,1-2H3,(H,24,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
Centre de Recherches Curated by ChEMBL					Assay Description Agonist activity at mouse PPARdelta assessed as receptor activation by cell based assay				Bioorg Med Chem Lett 18: 710-5 (2008) Article DOI: 10.1016/j.bmcl.2007.11.053 BindingDB Entry DOI: 10.7270/Q2542NBN
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (Homo sapiens (Human))	BDBM50229220 (CHEMBL254744 | N-(4-(methylsulfonamido)benzyl)-4-m...) Show SMILES Cc1nc(sc1C(=O)NCc1ccc(NS(C)(=O)=O)cc1)-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C20H18F3N3O3S2/c1-12-17(30-19(25-12)14-5-7-15(8-6-14)20(21,22)23)18(27)24-11-13-3-9-16(10-4-13)26-31(2,28)29/h3-10,26H,11H2,1-2H3,(H,24,27)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
Centre de Recherches Curated by ChEMBL					Assay Description Agonist activity at human PPARdelta assessed as receptor activation by cell based assay				Bioorg Med Chem Lett 18: 710-5 (2008) Article DOI: 10.1016/j.bmcl.2007.11.053 BindingDB Entry DOI: 10.7270/Q2542NBN
					More data for this Ligand-Target Pair