BDBM50229422 CHEMBL4102856

SMILES: CN(Cc1cc(F)cc(F)c1F)C(=O)C1(CCCC1)C(F)(F)F

InChI Key: InChIKey=GGXXGMFIAAVXCA-UHFFFAOYSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50229422   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM50229422 (CHEMBL4102856) Show SMILES CN(Cc1cc(F)cc(F)c1F)C(=O)C1(CCCC1)C(F)(F)F Show InChI InChI=1S/C15H15F6NO/c1-22(8-9-6-10(16)7-11(17)12(9)18)13(23)14(15(19,20)21)4-2-3-5-14/h6-7H,2-5,8H2,1H3	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	1.23E+3	n/a	n/a	n/a	n/a
National Institute of Biological Sciences Curated by ChEMBL					Assay Description Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...				J Med Chem 60: 972-986 (2017) BindingDB Entry DOI: 10.7270/Q2QC05QD
					More data for this Ligand-Target Pair