BDBM50229603 CHEMBL4090332
SMILES: CCC(C)(C)C(=O)NCc1ccccc1F
InChI Key: InChIKey=QRJRCHHZMYZEDC-UHFFFAOYSA-N
Data: 1 EC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human)) | BDBM50229603 (CHEMBL4090332) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | n/a | 898 | n/a | n/a | n/a | n/a |
National Institute of Biological Sciences Curated by ChEMBL | Assay Description Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ... | J Med Chem 60: 972-986 (2017) BindingDB Entry DOI: 10.7270/Q2QC05QD | |||||||||||
More data for this Ligand-Target Pair |