BDBM50229609 CHEMBL4103563

SMILES: CC1CCCC(C)N1C(=O)N(C)Cc1cc(F)cc(F)c1F

InChI Key: InChIKey=XOQAOYATPLWFQM-UHFFFAOYSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50229609   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM50229609 (CHEMBL4103563) Show SMILES CC1CCCC(C)N1C(=O)N(C)Cc1cc(F)cc(F)c1F Show InChI InChI=1S/C16H21F3N2O/c1-10-5-4-6-11(2)21(10)16(22)20(3)9-12-7-13(17)8-14(18)15(12)19/h7-8,10-11H,4-6,9H2,1-3H3	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	1.53E+3	n/a	n/a	n/a	n/a
National Institute of Biological Sciences Curated by ChEMBL					Assay Description Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...				J Med Chem 60: 972-986 (2017) BindingDB Entry DOI: 10.7270/Q2QC05QD
					More data for this Ligand-Target Pair