BDBM50230170 CHEMBL4100979

SMILES: Nc1n[nH]c2cccc(-c3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)c(F)c4)cc3)c12

InChI Key: InChIKey=DEMGLABBZSLUOH-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50230170   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Ephrin type-B receptor 4 (Homo sapiens (Human))	BDBM50230170 (CHEMBL4100979) Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)c(F)c4)cc3)c12 Show InChI InChI=1S/C24H19F2N5O2/c25-17-9-8-15(12-18(17)26)29-23(33)24(10-11-24)22(32)28-14-6-4-13(5-7-14)16-2-1-3-19-20(16)21(27)31-30-19/h1-9,12H,10-11H2,(H,28,32)(H,29,33)(H3,27,30,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.130	n/a	n/a	n/a	n/a	n/a	n/a
Xi'an Jiaotong University Curated by ChEMBL					Assay Description Inhibition of EphB4 (unknown origin) after 60 mins by ADP-Glo assay				Eur J Med Chem 127: 275-285 (2017) BindingDB Entry DOI: 10.7270/Q2XW4N27
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50230170 (CHEMBL4100979) Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)c(F)c4)cc3)c12 Show InChI InChI=1S/C24H19F2N5O2/c25-17-9-8-15(12-18(17)26)29-23(33)24(10-11-24)22(32)28-14-6-4-13(5-7-14)16-2-1-3-19-20(16)21(27)31-30-19/h1-9,12H,10-11H2,(H,28,32)(H,29,33)(H3,27,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
Xi'an Jiaotong University Curated by ChEMBL					Assay Description Inhibition of VEGFR2 (unknown origin) after 60 mins by ADP-Glo assay				Eur J Med Chem 127: 275-285 (2017) BindingDB Entry DOI: 10.7270/Q2XW4N27
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor (Homo sapiens (Human))	BDBM50230170 (CHEMBL4100979) Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)c(F)c4)cc3)c12 Show InChI InChI=1S/C24H19F2N5O2/c25-17-9-8-15(12-18(17)26)29-23(33)24(10-11-24)22(32)28-14-6-4-13(5-7-14)16-2-1-3-19-20(16)21(27)31-30-19/h1-9,12H,10-11H2,(H,28,32)(H,29,33)(H3,27,30,31)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	24	n/a	n/a	n/a	n/a	n/a	n/a
Xi'an Jiaotong University Curated by ChEMBL					Assay Description Inhibition of TIE-2 (unknown origin) after 60 mins by ADP-Glo assay				Eur J Med Chem 127: 275-285 (2017) BindingDB Entry DOI: 10.7270/Q2XW4N27
					More data for this Ligand-Target Pair