BDBM50230177 CHEMBL4071731

SMILES: Nc1n[nH]c2cccc(-c3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(OC(F)(F)F)cc4Br)cc3)c12

InChI Key: InChIKey=UCVJQRATLIFUON-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50230177   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Angiopoietin-1 receptor (Homo sapiens (Human))	BDBM50230177 (CHEMBL4071731) Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(OC(F)(F)F)cc4Br)cc3)c12 Show InChI InChI=1S/C25H19BrF3N5O3/c26-17-12-15(37-25(27,28)29)8-9-18(17)32-23(36)24(10-11-24)22(35)31-14-6-4-13(5-7-14)16-2-1-3-19-20(16)21(30)34-33-19/h1-9,12H,10-11H2,(H,31,35)(H,32,36)(H3,30,33,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Xi'an Jiaotong University Curated by ChEMBL					Assay Description Inhibition of TIE-2 (unknown origin) after 60 mins by ADP-Glo assay				Eur J Med Chem 127: 275-285 (2017) BindingDB Entry DOI: 10.7270/Q2XW4N27
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50230177 (CHEMBL4071731) Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(OC(F)(F)F)cc4Br)cc3)c12 Show InChI InChI=1S/C25H19BrF3N5O3/c26-17-12-15(37-25(27,28)29)8-9-18(17)32-23(36)24(10-11-24)22(35)31-14-6-4-13(5-7-14)16-2-1-3-19-20(16)21(30)34-33-19/h1-9,12H,10-11H2,(H,31,35)(H,32,36)(H3,30,33,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Xi'an Jiaotong University Curated by ChEMBL					Assay Description Inhibition of VEGFR2 (unknown origin) after 60 mins by ADP-Glo assay				Eur J Med Chem 127: 275-285 (2017) BindingDB Entry DOI: 10.7270/Q2XW4N27
					More data for this Ligand-Target Pair
Ephrin type-B receptor 4 (Homo sapiens (Human))	BDBM50230177 (CHEMBL4071731) Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(OC(F)(F)F)cc4Br)cc3)c12 Show InChI InChI=1S/C25H19BrF3N5O3/c26-17-12-15(37-25(27,28)29)8-9-18(17)32-23(36)24(10-11-24)22(35)31-14-6-4-13(5-7-14)16-2-1-3-19-20(16)21(30)34-33-19/h1-9,12H,10-11H2,(H,31,35)(H,32,36)(H3,30,33,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	3.60	n/a	n/a	n/a	n/a	n/a	n/a
Xi'an Jiaotong University Curated by ChEMBL					Assay Description Inhibition of EphB4 (unknown origin) after 60 mins by ADP-Glo assay				Eur J Med Chem 127: 275-285 (2017) BindingDB Entry DOI: 10.7270/Q2XW4N27
					More data for this Ligand-Target Pair