BDBM50230993 (2S)-2-amino-5-[(N-methylcarbamimidoyl)amino]pentanoic acid::(2S)-2-ammonio-5-{[iminio(methylamino)methyl]amino}pentanoate::(R)-2-Amino-5-(N'-methyl-guanidino)-pentanoic acid::(S)-2-Amino-5-(N'-methyl-guanidino)-pentanoic acid::(S)-2-amino-5-(2-methylguanidino)pentanoic acid::(S)-2-amino-5-(3-methylguanidino)pentanoic acid::2-Amino-5-(N'-methyl-guanidino)-pentanoic acid::CHEMBL256147::L-NMMA::N omega-methyl-L-arginine::N(G)-mono-methyl-L-arginine::N(G)-monomethyl-L-arginine::N-Monomethyl-L-arginine::N-gamma-monomethyl-L-arginine::NG-Monomethyl-L-Arginine::NG-monomethyl-L-arginine acetate::Ngamma-monomethyl-L-arginine::Targinine
SMILES: CNC(N)=NCCC[C@H](N)C(O)=O
InChI Key: InChIKey=NTNWOCRCBQPEKQ-YFKPBYRVSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Nitric-oxide synthase, brain (Rattus norvegicus (rat)) | BDBM50230993 ((2S)-2-amino-5-[(N-methylcarbamimidoyl)amino]penta...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Northwestern University Curated by ChEMBL | Assay Description Inhibition of rat nNOS | J Med Chem 56: 3121-47 (2013) Article DOI: 10.1021/jm3015926 BindingDB Entry DOI: 10.7270/Q23T9JKG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nitric oxide synthase, endothelial (Homo sapiens (Human)) | BDBM50230993 ((2S)-2-amino-5-[(N-methylcarbamimidoyl)amino]penta...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article | 400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibitory constant for the inhibition of human Endothelial nitric oxide synthase | Bioorg Med Chem Lett 7: 1763-1768 (1997) Article DOI: 10.1016/S0960-894X(97)00309-0 BindingDB Entry DOI: 10.7270/Q2TQ61J5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nitric oxide synthase, endothelial (Homo sapiens (Human)) | BDBM50230993 ((2S)-2-amino-5-[(N-methylcarbamimidoyl)amino]penta...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Wellcome Research and Development Curated by ChEMBL | Assay Description Inhibitory activity against human endothelial nitric oxide synthase (eNOS) isoenzyme. | J Med Chem 41: 2858-71 (1998) Article DOI: 10.1021/jm980072p BindingDB Entry DOI: 10.7270/Q2862H4X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nitric oxide synthase, brain (Homo sapiens (Human)) | BDBM50230993 ((2S)-2-amino-5-[(N-methylcarbamimidoyl)amino]penta...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article | 840 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibitory constant for the inhibition of human Neuronal nitric oxide synthase | Bioorg Med Chem Lett 7: 1763-1768 (1997) Article DOI: 10.1016/S0960-894X(97)00309-0 BindingDB Entry DOI: 10.7270/Q2TQ61J5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nitric oxide synthase, brain (Homo sapiens (Human)) | BDBM50230993 ((2S)-2-amino-5-[(N-methylcarbamimidoyl)amino]penta...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 840 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Wellcome Research and Development Curated by ChEMBL | Assay Description Inhibitory activity against human neuronal nitric oxide synthase (nNOS) isoenzyme. | J Med Chem 41: 2858-71 (1998) Article DOI: 10.1021/jm980072p BindingDB Entry DOI: 10.7270/Q2862H4X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nitric oxide synthase, inducible (Homo sapiens (Human)) | BDBM50230993 ((2S)-2-amino-5-[(N-methylcarbamimidoyl)amino]penta...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 860 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Wellcome Research and Development Curated by ChEMBL | Assay Description Inhibitory activity against human inducible nitric oxide synthase (iNOS) isoenzyme. | J Med Chem 41: 2858-71 (1998) Article DOI: 10.1021/jm980072p BindingDB Entry DOI: 10.7270/Q2862H4X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nitric oxide synthase, inducible (Homo sapiens (Human)) | BDBM50230993 ((2S)-2-amino-5-[(N-methylcarbamimidoyl)amino]penta...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article | 860 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibitory constant for the inhibition of human Inducible nitric oxide synthase | Bioorg Med Chem Lett 7: 1763-1768 (1997) Article DOI: 10.1016/S0960-894X(97)00309-0 BindingDB Entry DOI: 10.7270/Q2TQ61J5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nitric oxide synthase, inducible (Homo sapiens (Human)) | BDBM50230993 ((2S)-2-amino-5-[(N-methylcarbamimidoyl)amino]penta...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Rahway Curated by ChEMBL | Assay Description Inhibitory activity against inducible nitric oxide synthase (iNOS) | Bioorg Med Chem Lett 10: 1975-8 (2001) BindingDB Entry DOI: 10.7270/Q2319V30 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nitric oxide synthase, endothelial (Homo sapiens (Human)) | BDBM50230993 ((2S)-2-amino-5-[(N-methylcarbamimidoyl)amino]penta...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca R&D Charnwood Curated by ChEMBL | Assay Description Ability to inhibit conversion of [3H]-L-Arg to [3H]-L-citrulline catalyzed by endothelial NOS (e NOS) from HUVEC cells | Bioorg Med Chem Lett 11: 1023-6 (2001) BindingDB Entry DOI: 10.7270/Q2K073JZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nitric oxide synthase, inducible (Homo sapiens (Human)) | BDBM50230993 ((2S)-2-amino-5-[(N-methylcarbamimidoyl)amino]penta...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 1.70E+8 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca R&D Charnwood Curated by ChEMBL | Assay Description Inhibitory concentration against nitric oxide synthesis in intact DLD-1 cells | Bioorg Med Chem Lett 11: 1023-6 (2001) BindingDB Entry DOI: 10.7270/Q2K073JZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nitric-oxide synthase, brain (Rattus norvegicus (rat)) | BDBM50230993 ((2S)-2-amino-5-[(N-methylcarbamimidoyl)amino]penta...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca R&D Charnwood Curated by ChEMBL | Assay Description Inhibition of conversion of [3H]-L-Arg to [3H]-L-citrulline catalyzed by neuronal NOS (n NOS) from rat cerebellum | Bioorg Med Chem Lett 11: 1023-6 (2001) BindingDB Entry DOI: 10.7270/Q2K073JZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nitric-oxide synthase, brain (Rattus norvegicus (rat)) | BDBM50230993 ((2S)-2-amino-5-[(N-methylcarbamimidoyl)amino]penta...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca R&D Charnwood Curated by ChEMBL | Assay Description Ability to inhibit the conversion of [3H]-L-Arg to [3H]-L-citrulline catalyzed by n-NOS from rat cerebellum | Bioorg Med Chem Lett 11: 1027-30 (2001) BindingDB Entry DOI: 10.7270/Q2F76BT7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nitric oxide synthase, inducible (Homo sapiens (Human)) | BDBM50230993 ((2S)-2-amino-5-[(N-methylcarbamimidoyl)amino]penta...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca R&D Charnwood Curated by ChEMBL | Assay Description Ability to inhibit the conversion of [3H]-L-Arg to [3H]-L-citrulline catalyzed by i-NOS from human DLD-1 cells | Bioorg Med Chem Lett 11: 1027-30 (2001) BindingDB Entry DOI: 10.7270/Q2F76BT7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nitric oxide synthase, endothelial (Homo sapiens (Human)) | BDBM50230993 ((2S)-2-amino-5-[(N-methylcarbamimidoyl)amino]penta...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca R&D Charnwood Curated by ChEMBL | Assay Description Ability to inhibit the conversion of [3H]-L-Arg to [3H]-L-citrulline catalyzed by e-NOS from HUVECcells | Bioorg Med Chem Lett 11: 1027-30 (2001) BindingDB Entry DOI: 10.7270/Q2F76BT7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nitric-oxide synthase, brain (Mus musculus) | BDBM50230993 ((2S)-2-amino-5-[(N-methylcarbamimidoyl)amino]penta...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 4.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Dainippon Pharmaceutical Co., Ltd Curated by ChEMBL | Assay Description Inhibition of neuronal nitric oxide synthase (nNOS) in mice | Bioorg Med Chem Lett 14: 313-6 (2003) BindingDB Entry DOI: 10.7270/Q2XP74C4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nitric Oxide Synthase, inducible (Mus musculus (mouse)) | BDBM50230993 ((2S)-2-amino-5-[(N-methylcarbamimidoyl)amino]penta...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 1.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Dainippon Pharmaceutical Co., Ltd Curated by ChEMBL | Assay Description Inhibition of inducible nitric oxide synthase (iNOS) in mice | Bioorg Med Chem Lett 14: 313-6 (2003) BindingDB Entry DOI: 10.7270/Q2XP74C4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nitric Oxide Synthase, inducible (Mus musculus (mouse)) | BDBM50230993 ((2S)-2-amino-5-[(N-methylcarbamimidoyl)amino]penta...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Mansoura University Curated by ChEMBL | Assay Description Inhibition of iNOS in ddY mouse peritoneal exudate cells after 20 hrs | J Nat Prod 67: 1119-24 (2004) Article DOI: 10.1021/np030529k BindingDB Entry DOI: 10.7270/Q22F7N6X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nitric Oxide Synthase, inducible (Mus musculus (mouse)) | BDBM50230993 ((2S)-2-amino-5-[(N-methylcarbamimidoyl)amino]penta...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 2.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Beni-Suef University Curated by ChEMBL | Assay Description Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced iNOS activity incubated for 30 mins prior to LPS challenge me... | Bioorg Med Chem 23: 3248-59 (2015) BindingDB Entry DOI: 10.7270/Q26H4K5F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nitric Oxide Synthase, inducible (Mus musculus (mouse)) | BDBM50230993 ((2S)-2-amino-5-[(N-methylcarbamimidoyl)amino]penta...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article | n/a | n/a | 2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound was tested in vitro for inhibitory activity against inducible nitric oxide synthase | Bioorg Med Chem Lett 6: 999-1002 (1996) Article DOI: 10.1016/0960-894X(96)00144-8 BindingDB Entry DOI: 10.7270/Q2TT4QZ3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nitric-oxide synthase, brain (Rattus norvegicus (rat)) | BDBM50230993 ((2S)-2-amino-5-[(N-methylcarbamimidoyl)amino]penta...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article | n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound was tested in vitro for inhibitory activity against nNOS(constitutive isoform found in neurons) | Bioorg Med Chem Lett 6: 999-1002 (1996) Article DOI: 10.1016/0960-894X(96)00144-8 BindingDB Entry DOI: 10.7270/Q2TT4QZ3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nitric Oxide Synthase, inducible (Mus musculus (mouse)) | BDBM50230993 ((2S)-2-amino-5-[(N-methylcarbamimidoyl)amino]penta...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 2.21E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Hawai'i at Hilo Curated by ChEMBL | Assay Description Inhibition of iNOS-mediated nitric oxide production in LPS-stimulated mouse RAW 264.7 cells pretreated 15 mins before LPS challenge measured after 20... | Bioorg Med Chem 19: 6182-95 (2011) Article DOI: 10.1016/j.bmc.2011.09.020 BindingDB Entry DOI: 10.7270/Q2Z89CTS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nitric oxide synthase, inducible (Homo sapiens (Human)) | BDBM50230993 ((2S)-2-amino-5-[(N-methylcarbamimidoyl)amino]penta...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 6.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Wellcome Research and Development Curated by ChEMBL | Assay Description Inhibition of human inducible nitric oxide synthase | Bioorg Med Chem Lett 10: 597-600 (2000) BindingDB Entry DOI: 10.7270/Q21C1XDN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nitric oxide synthase, endothelial (Homo sapiens (Human)) | BDBM50230993 ((2S)-2-amino-5-[(N-methylcarbamimidoyl)amino]penta...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 3.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Wellcome Research and Development Curated by ChEMBL | Assay Description Inhibition of human endothelial Nitric Oxide Synthase | Bioorg Med Chem Lett 10: 597-600 (2000) BindingDB Entry DOI: 10.7270/Q21C1XDN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nitric oxide synthase, brain (Homo sapiens (Human)) | BDBM50230993 ((2S)-2-amino-5-[(N-methylcarbamimidoyl)amino]penta...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 4.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Wellcome Research and Development Curated by ChEMBL | Assay Description Inhibition of human neuronal Nitric Oxide Synthase | Bioorg Med Chem Lett 10: 597-600 (2000) BindingDB Entry DOI: 10.7270/Q21C1XDN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nitric oxide synthase, endothelial (Homo sapiens (Human)) | BDBM50230993 ((2S)-2-amino-5-[(N-methylcarbamimidoyl)amino]penta...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 540 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering AG Curated by ChEMBL | Assay Description Inhibitory concentration against recombinant human Endothelial nitric oxide synthase | Bioorg Med Chem Lett 13: 1981-4 (2003) BindingDB Entry DOI: 10.7270/Q2FN16QG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nitric oxide synthase, brain (Homo sapiens (Human)) | BDBM50230993 ((2S)-2-amino-5-[(N-methylcarbamimidoyl)amino]penta...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 890 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering AG Curated by ChEMBL | Assay Description Inhibitory concentration against recombinant human (neuronal nitric oxide synthase) n-NOS | Bioorg Med Chem Lett 13: 1981-4 (2003) BindingDB Entry DOI: 10.7270/Q2FN16QG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nitric oxide synthase, inducible (Homo sapiens (Human)) | BDBM50230993 ((2S)-2-amino-5-[(N-methylcarbamimidoyl)amino]penta...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering AG Curated by ChEMBL | Assay Description Inhibitory concentration against human Inducible nitric oxide synthase | Bioorg Med Chem Lett 13: 1981-4 (2003) BindingDB Entry DOI: 10.7270/Q2FN16QG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nitric oxide synthase, endothelial (Homo sapiens (Human)) | BDBM50230993 ((2S)-2-amino-5-[(N-methylcarbamimidoyl)amino]penta...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 5.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Inhibition of cloned (from RNA) human endothelial constitutive Endothelial nitric oxide synthase (heNOS) | J Med Chem 41: 3675-83 (1998) Article DOI: 10.1021/jm970840x BindingDB Entry DOI: 10.7270/Q2XP75MP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nitric oxide synthase, brain (Homo sapiens (Human)) | BDBM50230993 ((2S)-2-amino-5-[(N-methylcarbamimidoyl)amino]penta...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Inhibition of cloned (from RNA) human Neuronal nitric oxide synthase | J Med Chem 41: 3675-83 (1998) Article DOI: 10.1021/jm970840x BindingDB Entry DOI: 10.7270/Q2XP75MP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nitric oxide synthase, inducible (Homo sapiens (Human)) | BDBM50230993 ((2S)-2-amino-5-[(N-methylcarbamimidoyl)amino]penta...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Inhibition of cloned (from RNA) human inducible nitric oxide synthase (hiNOS) | J Med Chem 41: 3675-83 (1998) Article DOI: 10.1021/jm970840x BindingDB Entry DOI: 10.7270/Q2XP75MP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nitric oxide synthase, inducible (Homo sapiens (Human)) | BDBM50230993 ((2S)-2-amino-5-[(N-methylcarbamimidoyl)amino]penta...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
NeurAxon Inc. Curated by ChEMBL | Assay Description Inhibition of human recombinant iNOS expressed in Sf9 cells assessed as reduction in conversion of [3H]L-arginine to [3H]L-citrulline preincubated fo... | J Med Chem 55: 2882-93 (2012) Article DOI: 10.1021/jm3000449 BindingDB Entry DOI: 10.7270/Q24F1RV1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nitric oxide synthase, endothelial (Homo sapiens (Human)) | BDBM50230993 ((2S)-2-amino-5-[(N-methylcarbamimidoyl)amino]penta...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 650 | n/a | n/a | n/a | n/a | n/a | n/a |
NeurAxon Inc. Curated by ChEMBL | Assay Description Inhibition of human eNOS expressed in Sf9 cells assessed as reduction in conversion of [3H]L-arginine to [3H]L-citrulline preincubated for 15 mins by... | J Med Chem 55: 2882-93 (2012) Article DOI: 10.1021/jm3000449 BindingDB Entry DOI: 10.7270/Q24F1RV1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nitric oxide synthase, brain (Homo sapiens (Human)) | BDBM50230993 ((2S)-2-amino-5-[(N-methylcarbamimidoyl)amino]penta...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 950 | n/a | n/a | n/a | n/a | n/a | n/a |
NeurAxon Inc. Curated by ChEMBL | Assay Description Inhibition of human nNOS expressed in Sf9 cells assessed as reduction in conversion of [3H]L-arginine to [3H]L-citrulline preincubated for 15 mins by... | J Med Chem 55: 2882-93 (2012) Article DOI: 10.1021/jm3000449 BindingDB Entry DOI: 10.7270/Q24F1RV1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nitric Oxide Synthase, inducible (Mus musculus (mouse)) | BDBM50230993 ((2S)-2-amino-5-[(N-methylcarbamimidoyl)amino]penta...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.97E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Purdue University Curated by ChEMBL | Assay Description Inhibition of LPS-induced iNOS activity in mouse RAW 264.7 cells assessed as inhibition of NO production pretreated with compound for 30 mins before ... | Bioorg Med Chem 20: 7030-9 (2012) Article DOI: 10.1016/j.bmc.2012.10.006 BindingDB Entry DOI: 10.7270/Q2RR20D5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nitric oxide synthase, brain (Homo sapiens (Human)) | BDBM50230993 ((2S)-2-amino-5-[(N-methylcarbamimidoyl)amino]penta...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 950 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition of human recombinant nNOS assessed as conversion of [3H]L-arginine to [3H]L-citrulline preincubated for 15 mins measured after 45 mins by ... | ACS Med Chem Lett 3: 227-231 (2012) Article DOI: 10.1021/ml200268w BindingDB Entry DOI: 10.7270/Q2TX3GF4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nitric oxide synthase, endothelial (Homo sapiens (Human)) | BDBM50230993 ((2S)-2-amino-5-[(N-methylcarbamimidoyl)amino]penta...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 650 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition of human recombinant eNOS assessed as conversion of [3H]L-arginine to [3H]L-citrulline preincubated for 15 mins measured after 45 mins by ... | ACS Med Chem Lett 3: 227-231 (2012) Article DOI: 10.1021/ml200268w BindingDB Entry DOI: 10.7270/Q2TX3GF4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nitric oxide synthase, inducible (Homo sapiens (Human)) | BDBM50230993 ((2S)-2-amino-5-[(N-methylcarbamimidoyl)amino]penta...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.80 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition of human recombinant iNOS assessed as conversion of [3H]L-arginine to [3H]L-citrulline preincubated for 15 mins measured after 45 mins by ... | ACS Med Chem Lett 3: 227-231 (2012) Article DOI: 10.1021/ml200268w BindingDB Entry DOI: 10.7270/Q2TX3GF4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nitric oxide synthase, endothelial (Homo sapiens (Human)) | BDBM50230993 ((2S)-2-amino-5-[(N-methylcarbamimidoyl)amino]penta...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 8.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Rahway Curated by ChEMBL | Assay Description Inhibitory activity against endothelial nitric oxide synthase (eNOS) | Bioorg Med Chem Lett 10: 1975-8 (2001) BindingDB Entry DOI: 10.7270/Q2319V30 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nitric oxide synthase, brain (Homo sapiens (Human)) | BDBM50230993 ((2S)-2-amino-5-[(N-methylcarbamimidoyl)amino]penta...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 2.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Rahway Curated by ChEMBL | Assay Description Inhibitory activity against neuronal nitric oxide synthase | Bioorg Med Chem Lett 10: 1975-8 (2001) BindingDB Entry DOI: 10.7270/Q2319V30 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nitric Oxide Synthase, inducible (Mus musculus (mouse)) | BDBM50230993 ((2S)-2-amino-5-[(N-methylcarbamimidoyl)amino]penta...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories Curated by ChEMBL | Assay Description Inhibition of radiolabeled arginine conversion to citrulline by isomeric form of Inducible nitric oxide synthase from mouse RAW 264.7 cells | J Med Chem 41: 2636-42 (1998) Article DOI: 10.1021/jm980073h BindingDB Entry DOI: 10.7270/Q26Q1WD7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nitric Oxide Synthase, endothelial (Bos taurus (bovine)) | BDBM50230993 ((2S)-2-amino-5-[(N-methylcarbamimidoyl)amino]penta...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 7.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories Curated by ChEMBL | Assay Description Inhibitory activity of conversion of radiolabeled arginine to citrulline by isomeric form of nitric oxide synthase Endothelial nitric oxide synthase ... | J Med Chem 41: 2636-42 (1998) Article DOI: 10.1021/jm980073h BindingDB Entry DOI: 10.7270/Q26Q1WD7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nitric-oxide synthase, brain (Rattus norvegicus (rat)) | BDBM50230993 ((2S)-2-amino-5-[(N-methylcarbamimidoyl)amino]penta...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 7.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories Curated by ChEMBL | Assay Description Inhibitory activity against isomeric form of Neuronal nitric oxide synthase measured by citrulline assay | J Med Chem 41: 2636-42 (1998) Article DOI: 10.1021/jm980073h BindingDB Entry DOI: 10.7270/Q26Q1WD7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nitric oxide synthase, inducible (Homo sapiens (Human)) | BDBM50230993 ((2S)-2-amino-5-[(N-methylcarbamimidoyl)amino]penta...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca R&D Charnwood Curated by ChEMBL | Assay Description Inhibitory concentration against nitric oxide synthesis in intact DLD-1 cells | Bioorg Med Chem Lett 11: 1023-6 (2001) BindingDB Entry DOI: 10.7270/Q2K073JZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nitric oxide synthase, endothelial (Homo sapiens (Human)) | BDBM50230993 ((2S)-2-amino-5-[(N-methylcarbamimidoyl)amino]penta...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 6.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Washington University Medical School Curated by ChEMBL | Assay Description The compound was evaluated for the inhibitory potencies using human Endothelial nitric oxide synthase | J Med Chem 39: 5110-8 (1997) Article DOI: 10.1021/jm960481q BindingDB Entry DOI: 10.7270/Q29W0DKZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nitric oxide synthase, inducible (Homo sapiens (Human)) | BDBM50230993 ((2S)-2-amino-5-[(N-methylcarbamimidoyl)amino]penta...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 2.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Washington University Medical School Curated by ChEMBL | Assay Description The compound was evaluated for the inhibitory potencies using human Inducible nitric oxide synthase (hiNOS) | J Med Chem 39: 5110-8 (1997) Article DOI: 10.1021/jm960481q BindingDB Entry DOI: 10.7270/Q29W0DKZ | |||||||||||
More data for this Ligand-Target Pair |