BDBM50231282 1-(3-aminobenzo[d]isoxazol-5-yl)-6-[4-(3-dimethylaminomethylpyridin-4-yl)-2-fluorophenyl]-7-fluoro-1H-indazole-3-carboxylicacid amide::CHEMBL255052
SMILES: CN(C)Cc1cnccc1-c1ccc(c(F)c1)-c1ccc2c(nn(-c3ccc4onc(N)c4c3)c2c1F)C(N)=O
InChI Key: InChIKey=MAQKQDYMLDYTKU-UHFFFAOYSA-N
Data: 1 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Coagulation factor X (Homo sapiens (Human)) | BDBM50231282 (1-(3-aminobenzo[d]isoxazol-5-yl)-6-[4-(3-dimethyla...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL | Assay Description Inhibition of human factor 10a | J Med Chem 51: 282-97 (2008) Article DOI: 10.1021/jm701217r BindingDB Entry DOI: 10.7270/Q2K64HTF | |||||||||||
More data for this Ligand-Target Pair |