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SMILES: Fc1ccc2C(CCc2c1N1CCOCC1)NC(=O)Nc1cccc2[nH]ncc12

InChI Key: InChIKey=JYYDBVOVDJIMDV-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50232128   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM50232128
PNG
(1-(1H-Indazol-4-yl)-3-(5-fluoro-4-morpholin-1-yl-i...)
Show SMILES Fc1ccc2C(CCc2c1N1CCOCC1)NC(=O)Nc1cccc2[nH]ncc12 |w:5.18|
Show InChI InChI=1S/C21H22FN5O2/c22-16-6-4-13-14(20(16)27-8-10-29-11-9-27)5-7-18(13)25-21(28)24-17-2-1-3-19-15(17)12-23-26-19/h1-4,6,12,18H,5,7-11H2,(H,23,26)(H2,24,25,28)
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n/an/a 5n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Blockade of human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium flux

J Med Chem 51: 392-5 (2008)


Article DOI: 10.1021/jm701007g
BindingDB Entry DOI: 10.7270/Q218367F
More data for this
Ligand-Target Pair