BDBM50233520 FEVIPIPRANT::Fevipiprant::NVP-QAW039::QAW039
SMILES: Cc1c(CC(O)=O)c2cccnc2n1Cc1ccc(cc1C(F)(F)F)S(C)(=O)=O
InChI Key: InChIKey=GFPPXZDRVCSVNR-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G protein-coupled receptor 44 (Homo sapiens (Human)) | BDBM50233520 (FEVIPIPRANT | Fevipiprant | NVP-QAW039 | QAW039) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem Similars | PDB PubMed | 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research Curated by ChEMBL | Assay Description Displacement of [3H]PGD2 from human DP2 receptor expressed in CHO cell membranes after 60 mins by scintillation proximity assay | ACS Med Chem Lett 8: 582-586 (2017) BindingDB Entry DOI: 10.7270/Q2TH8PXN | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Prostaglandin E2 receptor (Homo sapiens (Human)) | BDBM50233520 (FEVIPIPRANT | Fevipiprant | NVP-QAW039 | QAW039) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem Similars | PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research Curated by ChEMBL | Assay Description Antagonist activity at EP4 receptor (unknown origin) | ACS Med Chem Lett 8: 582-586 (2017) BindingDB Entry DOI: 10.7270/Q2TH8PXN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostanoid DP receptor (Homo sapiens (Human)) | BDBM50233520 (FEVIPIPRANT | Fevipiprant | NVP-QAW039 | QAW039) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem Similars | PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research Curated by ChEMBL | Assay Description Antagonist activity at DP1 receptor (unknown origin) | ACS Med Chem Lett 8: 582-586 (2017) BindingDB Entry DOI: 10.7270/Q2TH8PXN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 3A4 (Homo sapiens (Human)) | BDBM50233520 (FEVIPIPRANT | Fevipiprant | NVP-QAW039 | QAW039) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem Similars | PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research Curated by ChEMBL | Assay Description Inhibition of human CYP3A4 | ACS Med Chem Lett 8: 582-586 (2017) BindingDB Entry DOI: 10.7270/Q2TH8PXN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
G protein-coupled receptor 44 (Homo sapiens (Human)) | BDBM50233520 (FEVIPIPRANT | Fevipiprant | NVP-QAW039 | QAW039) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem Similars | PDB PubMed | n/a | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research Curated by ChEMBL | Assay Description Displacement of [3H]NVP-QAW039 from human DP2 receptor expressed in CHO cell membranes by TopCount scintillation assay | ACS Med Chem Lett 8: 582-586 (2017) BindingDB Entry DOI: 10.7270/Q2TH8PXN | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Cytochrome P450 2C9 (Homo sapiens (Human)) | BDBM50233520 (FEVIPIPRANT | Fevipiprant | NVP-QAW039 | QAW039) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem Similars | PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research Curated by ChEMBL | Assay Description Inhibition of human CYP2C9 | ACS Med Chem Lett 8: 582-586 (2017) BindingDB Entry DOI: 10.7270/Q2TH8PXN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostanoid IP receptor (Homo sapiens (Human)) | BDBM50233520 (FEVIPIPRANT | Fevipiprant | NVP-QAW039 | QAW039) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem Similars | PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research Curated by ChEMBL | Assay Description Antagonist activity at IP receptor (unknown origin) | ACS Med Chem Lett 8: 582-586 (2017) BindingDB Entry DOI: 10.7270/Q2TH8PXN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
G protein-coupled receptor 44 (Homo sapiens (Human)) | BDBM50233520 (FEVIPIPRANT | Fevipiprant | NVP-QAW039 | QAW039) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem Similars | PDB PubMed | n/a | n/a | 2.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research Curated by ChEMBL | Assay Description Antagonist activity at DP2 receptor in CD4-positive human TH2 cells assessed as inhibition of DK-PGD2-induced IL-5 production after 6 to 8 hrs | ACS Med Chem Lett 8: 582-586 (2017) BindingDB Entry DOI: 10.7270/Q2TH8PXN | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Prostaglandin E2 receptor (Homo sapiens (Human)) | BDBM50233520 (FEVIPIPRANT | Fevipiprant | NVP-QAW039 | QAW039) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem Similars | PubMed | n/a | n/a | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research Curated by ChEMBL | Assay Description Agonist activity at EP3 receptor (unknown origin) | ACS Med Chem Lett 8: 582-586 (2017) BindingDB Entry DOI: 10.7270/Q2TH8PXN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin F2-alpha receptor (Homo sapiens (Human)) | BDBM50233520 (FEVIPIPRANT | Fevipiprant | NVP-QAW039 | QAW039) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem Similars | PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research Curated by ChEMBL | Assay Description Antagonist activity at FP receptor (unknown origin) | ACS Med Chem Lett 8: 582-586 (2017) BindingDB Entry DOI: 10.7270/Q2TH8PXN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin E2 receptor (Homo sapiens (Human)) | BDBM50233520 (FEVIPIPRANT | Fevipiprant | NVP-QAW039 | QAW039) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem Similars | PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research Curated by ChEMBL | Assay Description Antagonist activity at EP2 receptor (unknown origin) | ACS Med Chem Lett 8: 582-586 (2017) BindingDB Entry DOI: 10.7270/Q2TH8PXN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
G protein-coupled receptor 44 (Homo sapiens (Human)) | BDBM50233520 (FEVIPIPRANT | Fevipiprant | NVP-QAW039 | QAW039) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem Similars | PDB PubMed | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research Curated by ChEMBL | Assay Description Antagonist activity at DP2 receptor in human whole assessed as inhibition of DK-PGD2-induced eosinophils shape change preincubated for 5 mins followe... | ACS Med Chem Lett 8: 582-586 (2017) BindingDB Entry DOI: 10.7270/Q2TH8PXN | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
G protein-coupled receptor 44 (Homo sapiens (Human)) | BDBM50233520 (FEVIPIPRANT | Fevipiprant | NVP-QAW039 | QAW039) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem Similars | PDB PubMed | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research Curated by ChEMBL | Assay Description Antagonist activity at DP2 receptor in human isolated eosinophils assessed as inhibition of DK-PGD2-induced shape change preincubated for 5 mins foll... | ACS Med Chem Lett 8: 582-586 (2017) BindingDB Entry DOI: 10.7270/Q2TH8PXN | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Cytochrome P450 1A2 (Homo sapiens (Human)) | BDBM50233520 (FEVIPIPRANT | Fevipiprant | NVP-QAW039 | QAW039) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem Similars | PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research Curated by ChEMBL | Assay Description Inhibition of human CYP1A2 | ACS Med Chem Lett 8: 582-586 (2017) BindingDB Entry DOI: 10.7270/Q2TH8PXN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
G protein-coupled receptor 44 (Homo sapiens (Human)) | BDBM50233520 (FEVIPIPRANT | Fevipiprant | NVP-QAW039 | QAW039) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem Similars | PDB PubMed | n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research Curated by ChEMBL | Assay Description Antagonist activity at DP2 receptor in CD4-positive human TH2 cells assessed as inhibition of DK-PGD2-induced IL-13 production after 6 to 8 hrs | ACS Med Chem Lett 8: 582-586 (2017) BindingDB Entry DOI: 10.7270/Q2TH8PXN | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Prostaglandin E2 receptor (Homo sapiens (Human)) | BDBM50233520 (FEVIPIPRANT | Fevipiprant | NVP-QAW039 | QAW039) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem Similars | PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research Curated by ChEMBL | Assay Description Antagonist activity at EP3 receptor (unknown origin) | ACS Med Chem Lett 8: 582-586 (2017) BindingDB Entry DOI: 10.7270/Q2TH8PXN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thromboxane A2 receptor (Homo sapiens (Human)) | BDBM50233520 (FEVIPIPRANT | Fevipiprant | NVP-QAW039 | QAW039) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem Similars | PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research Curated by ChEMBL | Assay Description Antagonist activity at TP receptor (unknown origin) | ACS Med Chem Lett 8: 582-586 (2017) BindingDB Entry DOI: 10.7270/Q2TH8PXN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostanoid IP receptor (Homo sapiens (Human)) | BDBM50233520 (FEVIPIPRANT | Fevipiprant | NVP-QAW039 | QAW039) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem Similars | PubMed | n/a | n/a | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research Curated by ChEMBL | Assay Description Agonist activity at IP receptor (unknown origin) | ACS Med Chem Lett 8: 582-586 (2017) BindingDB Entry DOI: 10.7270/Q2TH8PXN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 2D6 (Homo sapiens (Human)) | BDBM50233520 (FEVIPIPRANT | Fevipiprant | NVP-QAW039 | QAW039) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem Similars | PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research Curated by ChEMBL | Assay Description Inhibition of human CYP2D6 | ACS Med Chem Lett 8: 582-586 (2017) BindingDB Entry DOI: 10.7270/Q2TH8PXN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
G protein-coupled receptor 44 (Homo sapiens (Human)) | BDBM50233520 (FEVIPIPRANT | Fevipiprant | NVP-QAW039 | QAW039) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem Similars | PDB PubMed | n/a | n/a | 3.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research Curated by ChEMBL | Assay Description Antagonist activity at DP2 receptor in CD4-positive human TH2 cells assessed as inhibition of DK-PGD2-induced IL-5 production after 6 to 8 hrs | ACS Med Chem Lett 8: 582-586 (2017) BindingDB Entry DOI: 10.7270/Q2TH8PXN | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |