BDBM50233673 (+)-2-(4-(1-oxoisoindolin-2-yl)phenyl)propanoic acid::2-(4-(1-oxoisoindolin-2-yl)phenyl)propanoic acid::2-[4-(1-Oxo-1,3-dihydro-isoindol-2-yl)-phenyl]-propionic acid::CHEMBL15870::INDOPROFEN::cid_3718

SMILES: CC(C(O)=O)c1ccc(cc1)N1Cc2ccccc2C1=O

InChI Key: InChIKey=RJMIEHBSYVWVIN-UHFFFAOYSA-N

Data: 2 KI  5 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50233673   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Liver fatty acid binding protein (rat L-FABP) (Rattus norvegicus (Rat))	BDBM50233673 ((+)-2-(4-(1-oxoisoindolin-2-yl)phenyl)propanoic ac...) Show SMILES CC(C(O)=O)c1ccc(cc1)N1Cc2ccccc2C1=O Show InChI InChI=1S/C17H15NO3/c1-11(17(20)21)12-6-8-14(9-7-12)18-10-13-4-2-3-5-15(13)16(18)19/h2-9,11H,10H2,1H3,(H,20,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars	Article PubMed	1.27E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Monash University (Parkville Campus) Curated by ChEMBL					Assay Description Displacement of 1-anilinonaphthalene-8-sulphonic acid from rat recombinant L-FABP high binding affinity site expressed in Escherichia coli BL21 by co...				J Med Chem 51: 3755-64 (2008) Article DOI: 10.1021/jm701192w BindingDB Entry DOI: 10.7270/Q2KH0P7G
					More data for this Ligand-Target Pair
Liver fatty acid binding protein (rat L-FABP) (Rattus norvegicus (Rat))	BDBM50233673 ((+)-2-(4-(1-oxoisoindolin-2-yl)phenyl)propanoic ac...) Show SMILES CC(C(O)=O)c1ccc(cc1)N1Cc2ccccc2C1=O Show InChI InChI=1S/C17H15NO3/c1-11(17(20)21)12-6-8-14(9-7-12)18-10-13-4-2-3-5-15(13)16(18)19/h2-9,11H,10H2,1H3,(H,20,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars	Article PubMed	1.61E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Monash University (Parkville Campus) Curated by ChEMBL					Assay Description Displacement of 1-anilinonaphthalene-8-sulphonic acid from rat recombinant L-FABP low binding affinity site expressed in Escherichia coli BL21 by com...				J Med Chem 51: 3755-64 (2008) Article DOI: 10.1021/jm701192w BindingDB Entry DOI: 10.7270/Q2KH0P7G
					More data for this Ligand-Target Pair
Caspase-3 (Homo sapiens (Human))	BDBM50233673 ((+)-2-(4-(1-oxoisoindolin-2-yl)phenyl)propanoic ac...) Show SMILES CC(C(O)=O)c1ccc(cc1)N1Cc2ccccc2C1=O Show InChI InChI=1S/C17H15NO3/c1-11(17(20)21)12-6-8-14(9-7-12)18-10-13-4-2-3-5-15(13)16(18)19/h2-9,11H,10H2,1H3,(H,20,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	7.4	n/a
University of Colorado					Assay Description Experiments were performed in a 384-well format (Greiner no. 781207) as per the conditions noted here. Caspase-1: 2.5 nM enzyme, 6.5 mM WEHD substrat...				Cell Chem Biol 24: 281-292 (2017) Article DOI: 10.1016/j.chembiol.2017.02.003 BindingDB Entry DOI: 10.7270/Q2C53JQX
					More data for this Ligand-Target Pair
Caspase-5 (Homo sapiens (Human))	BDBM50233673 ((+)-2-(4-(1-oxoisoindolin-2-yl)phenyl)propanoic ac...) Show SMILES CC(C(O)=O)c1ccc(cc1)N1Cc2ccccc2C1=O Show InChI InChI=1S/C17H15NO3/c1-11(17(20)21)12-6-8-14(9-7-12)18-10-13-4-2-3-5-15(13)16(18)19/h2-9,11H,10H2,1H3,(H,20,21)	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	590	n/a	n/a	n/a	n/a	7.4	n/a
University of Colorado					Assay Description Experiments were performed in a 384-well format (Greiner no. 781207) as per the conditions noted here. Caspase-1: 2.5 nM enzyme, 6.5 mM WEHD substrat...				Cell Chem Biol 24: 281-292 (2017) Article DOI: 10.1016/j.chembiol.2017.02.003 BindingDB Entry DOI: 10.7270/Q2C53JQX
					More data for this Ligand-Target Pair
Caspase-9 (Homo sapiens (Human))	BDBM50233673 ((+)-2-(4-(1-oxoisoindolin-2-yl)phenyl)propanoic ac...) Show SMILES CC(C(O)=O)c1ccc(cc1)N1Cc2ccccc2C1=O Show InChI InChI=1S/C17H15NO3/c1-11(17(20)21)12-6-8-14(9-7-12)18-10-13-4-2-3-5-15(13)16(18)19/h2-9,11H,10H2,1H3,(H,20,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	7.4	n/a
University of Colorado					Assay Description Experiments were performed in a 384-well format (Greiner no. 781207) as per the conditions noted here. Caspase-1: 2.5 nM enzyme, 6.5 mM WEHD substrat...				Cell Chem Biol 24: 281-292 (2017) Article DOI: 10.1016/j.chembiol.2017.02.003 BindingDB Entry DOI: 10.7270/Q2C53JQX
					More data for this Ligand-Target Pair
Caspase-1 (Homo sapiens (Human))	BDBM50233673 ((+)-2-(4-(1-oxoisoindolin-2-yl)phenyl)propanoic ac...) Show SMILES CC(C(O)=O)c1ccc(cc1)N1Cc2ccccc2C1=O Show InChI InChI=1S/C17H15NO3/c1-11(17(20)21)12-6-8-14(9-7-12)18-10-13-4-2-3-5-15(13)16(18)19/h2-9,11H,10H2,1H3,(H,20,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.60E+3	n/a	n/a	n/a	n/a	7.4	n/a
University of Colorado					Assay Description Experiments were performed in a 384-well format (Greiner no. 781207) as per the conditions noted here. Caspase-1: 2.5 nM enzyme, 6.5 mM WEHD substrat...				Cell Chem Biol 24: 281-292 (2017) Article DOI: 10.1016/j.chembiol.2017.02.003 BindingDB Entry DOI: 10.7270/Q2C53JQX
					More data for this Ligand-Target Pair
Nuclear factor NF-kappa-B (Homo sapiens (Human))	BDBM50233673 ((+)-2-(4-(1-oxoisoindolin-2-yl)phenyl)propanoic ac...) Show SMILES CC(C(O)=O)c1ccc(cc1)N1Cc2ccccc2C1=O Show InChI InChI=1S/C17H15NO3/c1-11(17(20)21)12-6-8-14(9-7-12)18-10-13-4-2-3-5-15(13)16(18)19/h2-9,11H,10H2,1H3,(H,20,21)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars	PCBioAssay	n/a	n/a	n/a	n/a	1.52E+3	n/a	n/a	n/a	n/a
SRMLSC Curated by PubChem BioAssay					Assay Description Southern Research Molecular Libraries Screening Center (SRMLSC) Southern Research Institute (Birmingham, Alabama) NIH Molecular Libraries Screening C...				PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q27P8WT7
					More data for this Ligand-Target Pair
Caspase-4 (Homo sapiens (Human))	BDBM50233673 ((+)-2-(4-(1-oxoisoindolin-2-yl)phenyl)propanoic ac...) Show SMILES CC(C(O)=O)c1ccc(cc1)N1Cc2ccccc2C1=O Show InChI InChI=1S/C17H15NO3/c1-11(17(20)21)12-6-8-14(9-7-12)18-10-13-4-2-3-5-15(13)16(18)19/h2-9,11H,10H2,1H3,(H,20,21)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	570	n/a	n/a	n/a	n/a	7.4	n/a
University of Colorado					Assay Description Experiments were performed in a 384-well format (Greiner no. 781207) as per the conditions noted here. Caspase-1: 2.5 nM enzyme, 6.5 mM WEHD substrat...				Cell Chem Biol 24: 281-292 (2017) Article DOI: 10.1016/j.chembiol.2017.02.003 BindingDB Entry DOI: 10.7270/Q2C53JQX
					More data for this Ligand-Target Pair