BDBM50233718 5-cyano-N-(2-(3-fluoropiperidin-1-yl)-4-(4-methylpiperazin-1-yl)phenyl)furan-2-carboxamide::CHEMBL252633
SMILES: CN1CCN(CC1)c1ccc(NC(=O)c2ccc(o2)C#N)c(c1)N1CCCC(F)C1
InChI Key: InChIKey=ZNOXGGBCSTZRGM-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Macrophage colony stimulating factor receptor (Homo sapiens (Human)) | BDBM50233718 (5-cyano-N-(2-(3-fluoropiperidin-1-yl)-4-(4-methylp...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 6.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research & Development Curated by ChEMBL | Assay Description Inhibition of human cytoplasmic FMS expressed in Sf9-baculovirus system after 80 mins by fluorescence polarization | Bioorg Med Chem Lett 18: 1642-8 (2008) Article DOI: 10.1016/j.bmcl.2008.01.059 BindingDB Entry DOI: 10.7270/Q2FB52PS | |||||||||||
More data for this Ligand-Target Pair |