BDBM50233795 (R)-tert-butyl 1-oxo-1-((3-(2,2,2-trifluoroethyl)-3H-imidazo[4,5-b]pyridin-2-yl)methylamino)-3-(2-(trifluoromethyl)phenyl)propan-2-ylcarbamate::CHEMBL252435

SMILES: CC(C)(C)OC(=O)N[C@H](Cc1ccccc1C(F)(F)F)C(=O)NCc1nc2cccnc2n1CC(F)(F)F

InChI Key: InChIKey=RGEPJDFLOZNYEV-QGZVFWFLSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50233795   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM50233795 ((R)-tert-butyl 1-oxo-1-((3-(2,2,2-trifluoroethyl)-...) Show SMILES CC(C)(C)OC(=O)N[C@H](Cc1ccccc1C(F)(F)F)C(=O)NCc1nc2cccnc2n1CC(F)(F)F Show InChI InChI=1S/C24H25F6N5O3/c1-22(2,3)38-21(37)34-17(11-14-7-4-5-8-15(14)24(28,29)30)20(36)32-12-18-33-16-9-6-10-31-19(16)35(18)13-23(25,26)27/h4-10,17H,11-13H2,1-3H3,(H,32,36)(H,34,37)/t17-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	81	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Blockade of human Nav1.7 channel expressed in HEK293 cells by FRET assay				Bioorg Med Chem Lett 18: 1696-701 (2008) Article DOI: 10.1016/j.bmcl.2008.01.047 BindingDB Entry DOI: 10.7270/Q2S46STP
					More data for this Ligand-Target Pair