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SMILES: OC1=C(C(c2ccc(Cl)cc2)c2c(O)c3ccccc3oc2=O)C(=O)c2ccccc2C1=O

InChI Key: InChIKey=NCYDLSAMQSZVNL-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50233978   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
DNA topoisomerase 2-alpha


(Homo sapiens (Human))		BDBM50233978
PNG
(CHEMBL4064565)
Show SMILES OC1=C(C(c2ccc(Cl)cc2)c2c(O)c3ccccc3oc2=O)C(=O)c2ccccc2C1=O |c:1|
Show InChI InChI=1S/C26H15ClO6/c27-14-11-9-13(10-12-14)19(21-23(29)17-7-3-4-8-18(17)33-26(21)32)20-22(28)15-5-1-2-6-16(15)24(30)25(20)31/h1-12,19,29,31H
PDB

UniProtKB/SwissProt

antibodypedia
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CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 1.00E+4n/an/an/an/an/an/a



Instituto Universitario de Bio-Org£nica (CIBICAN)

Curated by ChEMBL


Assay Description
Inhibition of human topoisomerase-2 alpha expressed in baculovirus infected insect cells assessed as reduction in enzyme-meditaed supercoiled pRYG DN...

Bioorg Med Chem Lett 27: 484-489 (2017)


BindingDB Entry DOI: 10.7270/Q25M67Z3
More data for this
Ligand-Target Pair