BDBM50233985 CHEMBL4087024

SMILES: OC1=C(C(c2ccccc2F)c2c(O)c3ccccc3oc2=O)C(=O)c2ccccc2C1=O

InChI Key: InChIKey=YKWMCZRXOOZIGR-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50233985   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
DNA topoisomerase II (Homo sapiens (Human))	BDBM50233985 (CHEMBL4087024) Show SMILES OC1=C(C(c2ccccc2F)c2c(O)c3ccccc3oc2=O)C(=O)c2ccccc2C1=O |c:1| Show InChI InChI=1S/C26H15FO6/c27-17-11-5-3-9-15(17)19(21-23(29)16-10-4-6-12-18(16)33-26(21)32)20-22(28)13-7-1-2-8-14(13)24(30)25(20)31/h1-12,19,29,31H	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Instituto Universitario de Bio-Org£nica (CIBICAN) Curated by ChEMBL					Assay Description Inhibition of human topoisomerase-2 alpha expressed in baculovirus infected insect cells assessed as reduction in enzyme-meditaed supercoiled pRYG DN...				Bioorg Med Chem Lett 27: 484-489 (2017) BindingDB Entry DOI: 10.7270/Q25M67Z3
					More data for this Ligand-Target Pair