BDBM50234204 CHEMBL4077986

SMILES: Nc1nc(O[C@H](c2ccc(Cl)cc2-c2cccc(c2)S(N)(=O)=O)C(F)(F)F)cc(n1)N1CCC2(CN[C@@H](C2)C(O)=O)CC1

InChI Key: InChIKey=ARRAJCDZHLXTIY-NZQKXSOJSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50234204   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tryptophan 5-hydroxylase 1 (Homo sapiens (Human))	BDBM50234204 (CHEMBL4077986) Show SMILES Nc1nc(O[C@H](c2ccc(Cl)cc2-c2cccc(c2)S(N)(=O)=O)C(F)(F)F)cc(n1)N1CCC2(CN[C@@H](C2)C(O)=O)CC1 |r| Show InChI InChI=1S/C27H28ClF3N6O5S/c28-16-4-5-18(19(11-16)15-2-1-3-17(10-15)43(33,40)41)23(27(29,30)31)42-22-12-21(35-25(32)36-22)37-8-6-26(7-9-37)13-20(24(38)39)34-14-26/h1-5,10-12,20,23,34H,6-9,13-14H2,(H,38,39)(H2,32,35,36)(H2,33,40,41)/t20-,23+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Karos Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of TPH1 (unknown origin)				Bioorg Med Chem Lett 27: 413-419 (2017) BindingDB Entry DOI: 10.7270/Q21V5H7S
					More data for this Ligand-Target Pair