BDBM50234727 2,4-dimethyl-1-oxy-pyridin-3-yl)-{4'-methyl-4-[(2-methyl-thiazol-4-ylmethyl)-phenyl-amino]-[1,4']bipiperidinyl-1'-yl}-methanone::CHEMBL255857
SMILES: Cc1nc(CN(C2CCN(CC2)C2(C)CCN(CC2)C(=O)c2c(C)cc[n+]([O-])c2C)c2ccccc2)cs1
InChI Key: InChIKey=DNXMKFAIRKHJIZ-UHFFFAOYSA-N
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human)) | BDBM50234727 (2,4-dimethyl-1-oxy-pyridin-3-yl)-{4'-methyl-4-[(2-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 1.22E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research Curated by ChEMBL | Assay Description Displacement of [3H]dofetilide from human ERG expressed in HEK293 cell membranes | Bioorg Med Chem Lett 18: 2000-5 (2008) Article DOI: 10.1016/j.bmcl.2008.01.108 BindingDB Entry DOI: 10.7270/Q2NC6229 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
C-C chemokine receptor type 5 (Macaca fascicularis) | BDBM50234727 (2,4-dimethyl-1-oxy-pyridin-3-yl)-{4'-methyl-4-[(2-...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 107 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research Curated by ChEMBL | Assay Description Displacement of radiolabeled MIP-1alpha from cynomolgus monkey CCR5 expressed in CHO cells | Bioorg Med Chem Lett 18: 2000-5 (2008) Article DOI: 10.1016/j.bmcl.2008.01.108 BindingDB Entry DOI: 10.7270/Q2NC6229 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
C-C chemokine receptor type 5 (Homo sapiens (Human)) | BDBM50234727 (2,4-dimethyl-1-oxy-pyridin-3-yl)-{4'-methyl-4-[(2-...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research Curated by ChEMBL | Assay Description Displacement of [125I]RANTES from human CCR5 expressed in CHO cells | Bioorg Med Chem Lett 18: 2000-5 (2008) Article DOI: 10.1016/j.bmcl.2008.01.108 BindingDB Entry DOI: 10.7270/Q2NC6229 | |||||||||||
More data for this Ligand-Target Pair |