BDBM50234967 CHEMBL4072652

SMILES: CC(C)(C)CNC(=O)C[C@H](NC(=O)N1CCC(CC1)NC(=O)c1cnccn1)C(=O)N[C@@H](CCc1ccccc1)C(=O)NCc1ccccc1Cl

InChI Key: InChIKey=YHCXPFPDBMZEBV-KYJUHHDHSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50234967   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
20S proteasome chymotrypsin-like (Homo sapiens (Human))	BDBM50234967 (CHEMBL4072652) Show SMILES CC(C)(C)CNC(=O)C[C@H](NC(=O)N1CCC(CC1)NC(=O)c1cnccn1)C(=O)N[C@@H](CCc1ccccc1)C(=O)NCc1ccccc1Cl |r| Show InChI InChI=1S/C37H47ClN8O5/c1-37(2,3)24-42-32(47)21-30(45-36(51)46-19-15-27(16-20-46)43-35(50)31-23-39-17-18-40-31)34(49)44-29(14-13-25-9-5-4-6-10-25)33(48)41-22-26-11-7-8-12-28(26)38/h4-12,17-18,23,27,29-30H,13-16,19-22,24H2,1-3H3,(H,41,48)(H,42,47)(H,43,50)(H,44,49)(H,45,51)/t29-,30-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
Hangzhou Xixi Hospital Curated by ChEMBL					Assay Description Inhibition of chymotrypsin-like activity of human 20S proteasome pretreated for 15 mins followed by Suc-Leu-Leu-Val-Tyr-AMC substrate addition by flu...				Eur J Med Chem 126: 1056-1070 (2017) Article DOI: 10.1016/j.ejmech.2016.12.034 BindingDB Entry DOI: 10.7270/Q2MK6G4X
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