BDBM50234978 CHEMBL4064404

SMILES: CC(C)(C)CNC(=O)C[C@H](NC(=O)N1CCC(CC1)C(=O)Nc1ccccn1)C(=O)N[C@@H](CCc1ccccc1)C(=O)NCc1ccccc1Cl

InChI Key: InChIKey=JEZXVUZBIQGGPF-CONSDPRKSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50234978   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Proteasome subunit beta type-1/beta type-5 (Homo sapiens (Human))	BDBM50234978 (CHEMBL4064404) Show SMILES CC(C)(C)CNC(=O)C[C@H](NC(=O)N1CCC(CC1)C(=O)Nc1ccccn1)C(=O)N[C@@H](CCc1ccccc1)C(=O)NCc1ccccc1Cl |r| Show InChI InChI=1S/C38H48ClN7O5/c1-38(2,3)25-42-33(47)23-31(44-37(51)46-21-18-27(19-22-46)34(48)45-32-15-9-10-20-40-32)36(50)43-30(17-16-26-11-5-4-6-12-26)35(49)41-24-28-13-7-8-14-29(28)39/h4-15,20,27,30-31H,16-19,21-25H2,1-3H3,(H,41,49)(H,42,47)(H,43,50)(H,44,51)(H,40,45,48)/t30-,31-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Hangzhou Xixi Hospital Curated by ChEMBL					Assay Description Inhibition of chymotrypsin-like activity of human 20S proteasome pretreated for 15 mins followed by Suc-Leu-Leu-Val-Tyr-AMC substrate addition by flu...				Eur J Med Chem 126: 1056-1070 (2017) Article DOI: 10.1016/j.ejmech.2016.12.034 BindingDB Entry DOI: 10.7270/Q2MK6G4X
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