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BDBM50235646 CHEMBL4087547

SMILES: CN(C)[C@H]1CN(Cc2ccn3ccnc3c2)C[C@@H]1c1cn(C)c2ccccc12

InChI Key: InChIKey=RLFVLAHATHWHJI-IRLDBZIGSA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50235646   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Polycomb protein EED (EED)


(Homo sapiens (Human))		BDBM50235646
PNG
(CHEMBL4087547)
Show SMILES CN(C)[C@H]1CN(Cc2ccn3ccnc3c2)C[C@@H]1c1cn(C)c2ccccc12 |r|
Show InChI InChI=1S/C23H27N5/c1-25(2)22-16-27(13-17-8-10-28-11-9-24-23(28)12-17)15-20(22)19-14-26(3)21-7-5-4-6-18(19)21/h4-12,14,20,22H,13,15-16H2,1-3H3/t20-,22+/m1/s1
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Article
PubMed
>5.00E+4n/an/an/an/an/an/an/an/a



AbbVie Inc.

Curated by ChEMBL


Assay Description
Inhibition of OG(488) labeled probe binding to GST-tagged EED (unknown origin) after 1 hr by LanthaScreen TR-FRET assay

Bioorg Med Chem Lett 27: 1576-1583 (2017)


Article DOI: 10.1016/j.bmcl.2017.02.030
BindingDB Entry DOI: 10.7270/Q22F7QQG
More data for this
Ligand-Target Pair