Found 6 hits for monomerid = 50235705 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Histone deacetylase 7
(Homo sapiens (Human)) | BDBM50235705
(CHEMBL4093113)Show SMILES ONC(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(=O)Nc1cccc(Cl)c1 Show InChI InChI=1S/C14H7ClF12N2O3/c15-5-2-1-3-6(4-5)28-7(30)9(16,17)11(20,21)13(24,25)14(26,27)12(22,23)10(18,19)8(31)29-32/h1-4,32H,(H,28,30)(H,29,31) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL MMDB PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Applied Sciences Darmstadt
Curated by ChEMBL
| Assay Description Inhibitory potency against Varicella zoster virus ribonucleotide reductase |
Bioorg Med Chem Lett 27: 1508-1512 (2017)
Article DOI: 10.1016/j.bmcl.2017.02.050 BindingDB Entry DOI: 10.7270/Q2JD502H |
More data for this Ligand-Target Pair | |
Cereblon/Histone deacetylase 6
(Homo sapiens (Human)) | BDBM50235705
(CHEMBL4093113)Show SMILES ONC(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(=O)Nc1cccc(Cl)c1 Show InChI InChI=1S/C14H7ClF12N2O3/c15-5-2-1-3-6(4-5)28-7(30)9(16,17)11(20,21)13(24,25)14(26,27)12(22,23)10(18,19)8(31)29-32/h1-4,32H,(H,28,30)(H,29,31) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL MMDB PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Applied Sciences Darmstadt
Curated by ChEMBL
| Assay Description Inhibition of human HDAC6 using Boc-Lys(Ac)-AMC as substrate preincubated for 30 mins followed by substrate addition measured after 60 mins by trypsi... |
Bioorg Med Chem Lett 27: 1508-1512 (2017)
Article DOI: 10.1016/j.bmcl.2017.02.050 BindingDB Entry DOI: 10.7270/Q2JD502H |
More data for this Ligand-Target Pair | |
Histone deacetylase 5
(Homo sapiens (Human)) | BDBM50235705
(CHEMBL4093113)Show SMILES ONC(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(=O)Nc1cccc(Cl)c1 Show InChI InChI=1S/C14H7ClF12N2O3/c15-5-2-1-3-6(4-5)28-7(30)9(16,17)11(20,21)13(24,25)14(26,27)12(22,23)10(18,19)8(31)29-32/h1-4,32H,(H,28,30)(H,29,31) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL MMDB PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Applied Sciences Darmstadt
Curated by ChEMBL
| Assay Description Inhibition of human HDAC5 using Boc-Lys(trifluoroacetyl)-AMC as substrate preincubated for 30 mins followed by substrate addition measured after 60 m... |
Bioorg Med Chem Lett 27: 1508-1512 (2017)
Article DOI: 10.1016/j.bmcl.2017.02.050 BindingDB Entry DOI: 10.7270/Q2JD502H |
More data for this Ligand-Target Pair | |
Histone deacetylase 4
(Homo sapiens (Human)) | BDBM50235705
(CHEMBL4093113)Show SMILES ONC(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(=O)Nc1cccc(Cl)c1 Show InChI InChI=1S/C14H7ClF12N2O3/c15-5-2-1-3-6(4-5)28-7(30)9(16,17)11(20,21)13(24,25)14(26,27)12(22,23)10(18,19)8(31)29-32/h1-4,32H,(H,28,30)(H,29,31) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL MMDB PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Applied Sciences Darmstadt
Curated by ChEMBL
| Assay Description Inhibition of human HDAC4 using Boc-Lys(trifluoroacetyl)-AMC as substrate preincubated for 30 mins followed by substrate addition measured after 60 m... |
Bioorg Med Chem Lett 27: 1508-1512 (2017)
Article DOI: 10.1016/j.bmcl.2017.02.050 BindingDB Entry DOI: 10.7270/Q2JD502H |
More data for this Ligand-Target Pair | |
Histone deacetylase 8
(Homo sapiens (Human)) | BDBM50235705
(CHEMBL4093113)Show SMILES ONC(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(=O)Nc1cccc(Cl)c1 Show InChI InChI=1S/C14H7ClF12N2O3/c15-5-2-1-3-6(4-5)28-7(30)9(16,17)11(20,21)13(24,25)14(26,27)12(22,23)10(18,19)8(31)29-32/h1-4,32H,(H,28,30)(H,29,31) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL MMDB PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Applied Sciences Darmstadt
Curated by ChEMBL
| Assay Description Binding affinity at 5-hydroxytryptamine 3 receptor in rat entorhinal cortex by [3H]BRL-43694 displacement. |
Bioorg Med Chem Lett 27: 1508-1512 (2017)
Article DOI: 10.1016/j.bmcl.2017.02.050 BindingDB Entry DOI: 10.7270/Q2JD502H |
More data for this Ligand-Target Pair | |
Histone deacetylase 1
(Homo sapiens (Human)) | BDBM50235705
(CHEMBL4093113)Show SMILES ONC(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(=O)Nc1cccc(Cl)c1 Show InChI InChI=1S/C14H7ClF12N2O3/c15-5-2-1-3-6(4-5)28-7(30)9(16,17)11(20,21)13(24,25)14(26,27)12(22,23)10(18,19)8(31)29-32/h1-4,32H,(H,28,30)(H,29,31) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL MMDB PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Applied Sciences Darmstadt
Curated by ChEMBL
| Assay Description Inhibition of human HDAC1 using Boc-Lys(Ac)-AMC as substrate preincubated for 30 mins followed by substrate addition measured after 60 mins by trypsi... |
Bioorg Med Chem Lett 27: 1508-1512 (2017)
Article DOI: 10.1016/j.bmcl.2017.02.050 BindingDB Entry DOI: 10.7270/Q2JD502H |
More data for this Ligand-Target Pair | |