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SMILES: FC(F)(F)CNc1nc(Nc2ccc3cn[nH]c3c2)nc2ccoc12

InChI Key:

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 60 hits for monomerid = 50235820   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dual specificity protein kinase CLK2


(Homo sapiens (Human))
BDBM50235820
PNG
(CHEMBL4066664)
Show SMILES FC(F)(F)CNc1nc(Nc2ccc3cn[nH]c3c2)nc2ccoc12
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
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PC sid
UniChem
Article
PubMed
n/an/a 6.44E+3n/an/an/an/an/an/a



AbbVie Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibitory concentration against cyclin dependent kinase-2 (CDK2)/Cyclin E


Bioorg Med Chem Lett 26: 5562-5567 (2016)


Article DOI: 10.1016/j.bmcl.2016.09.077
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 9


(Homo sapiens (Human))
BDBM50235820
PNG
(CHEMBL4066664)
Show SMILES FC(F)(F)CNc1nc(Nc2ccc3cn[nH]c3c2)nc2ccoc12
PDB
MMDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



AbbVie Bioresearch Center

Curated by ChEMBL




Bioorg Med Chem Lett 26: 5562-5567 (2016)


Article DOI: 10.1016/j.bmcl.2016.09.077
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (Human))
BDBM50235820
PNG
(CHEMBL4066664)
Show SMILES FC(F)(F)CNc1nc(Nc2ccc3cn[nH]c3c2)nc2ccoc12
PDB
MMDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



AbbVie Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibitory concentration against cyclin dependent kinase-2 (CDK2)/Cyclin E


Bioorg Med Chem Lett 26: 5562-5567 (2016)


Article DOI: 10.1016/j.bmcl.2016.09.077
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM50235820
PNG
(CHEMBL4066664)
Show SMILES FC(F)(F)CNc1nc(Nc2ccc3cn[nH]c3c2)nc2ccoc12
PDB
MMDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



AbbVie Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibitory concentration against cyclin dependent kinase-2 (CDK2)/Cyclin E


Bioorg Med Chem Lett 26: 5562-5567 (2016)


Article DOI: 10.1016/j.bmcl.2016.09.077
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50235820
PNG
(CHEMBL4066664)
Show SMILES FC(F)(F)CNc1nc(Nc2ccc3cn[nH]c3c2)nc2ccoc12
PDB
MMDB

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n/an/an/an/a 235n/an/an/an/a



AbbVie Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibitory concentration against cyclin dependent kinase-2 (CDK2)/Cyclin E


Bioorg Med Chem Lett 26: 5562-5567 (2016)


Article DOI: 10.1016/j.bmcl.2016.09.077
More data for this
Ligand-Target Pair
CaM kinase I delta


(Homo sapiens (Human))
BDBM50235820
PNG
(CHEMBL4066664)
Show SMILES FC(F)(F)CNc1nc(Nc2ccc3cn[nH]c3c2)nc2ccoc12
PDB
MMDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



AbbVie Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibitory concentration against cyclin dependent kinase-2 (CDK2)/Cyclin E


Bioorg Med Chem Lett 26: 5562-5567 (2016)


Article DOI: 10.1016/j.bmcl.2016.09.077
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 4


(Homo sapiens (Human))
BDBM50235820
PNG
(CHEMBL4066664)
Show SMILES FC(F)(F)CNc1nc(Nc2ccc3cn[nH]c3c2)nc2ccoc12
PDB
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n/an/a>1.00E+4n/an/an/an/an/an/a



AbbVie Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibitory concentration against cyclin dependent kinase-2 (CDK2)/Cyclin E


Bioorg Med Chem Lett 26: 5562-5567 (2016)


Article DOI: 10.1016/j.bmcl.2016.09.077
More data for this
Ligand-Target Pair
Tyrosine kinase non-receptor protein 2


(Homo sapiens (Human))
BDBM50235820
PNG
(CHEMBL4066664)
Show SMILES FC(F)(F)CNc1nc(Nc2ccc3cn[nH]c3c2)nc2ccoc12
PDB
MMDB

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UniChem
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n/an/a 3.46E+3n/an/an/an/an/an/a



AbbVie Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibitory concentration against cyclin dependent kinase-2 (CDK2)/Cyclin E


Bioorg Med Chem Lett 26: 5562-5567 (2016)


Article DOI: 10.1016/j.bmcl.2016.09.077
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM50235820
PNG
(CHEMBL4066664)
Show SMILES FC(F)(F)CNc1nc(Nc2ccc3cn[nH]c3c2)nc2ccoc12
PDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



AbbVie Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibitory concentration against cyclin dependent kinase-2 (CDK2)/Cyclin E


Bioorg Med Chem Lett 26: 5562-5567 (2016)


Article DOI: 10.1016/j.bmcl.2016.09.077
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PAK 4


(Homo sapiens (Human))
BDBM50235820
PNG
(CHEMBL4066664)
Show SMILES FC(F)(F)CNc1nc(Nc2ccc3cn[nH]c3c2)nc2ccoc12
PDB
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n/an/a 6.44E+3n/an/an/an/an/an/a



AbbVie Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibitory concentration against cyclin dependent kinase-2 (CDK2)/Cyclin E


Bioorg Med Chem Lett 26: 5562-5567 (2016)


Article DOI: 10.1016/j.bmcl.2016.09.077
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))
BDBM50235820
PNG
(CHEMBL4066664)
Show SMILES FC(F)(F)CNc1nc(Nc2ccc3cn[nH]c3c2)nc2ccoc12
PDB
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n/an/a 5.33E+3n/an/an/an/an/an/a



AbbVie Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibitory concentration against cyclin dependent kinase-2 (CDK2)/Cyclin E


Bioorg Med Chem Lett 26: 5562-5567 (2016)


Article DOI: 10.1016/j.bmcl.2016.09.077
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM50235820
PNG
(CHEMBL4066664)
Show SMILES FC(F)(F)CNc1nc(Nc2ccc3cn[nH]c3c2)nc2ccoc12
PDB
MMDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



AbbVie Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibitory concentration against cyclin dependent kinase-2 (CDK2)/Cyclin E


Bioorg Med Chem Lett 26: 5562-5567 (2016)


Article DOI: 10.1016/j.bmcl.2016.09.077
More data for this
Ligand-Target Pair
Protein kinase C, PKC; classical/novel


(Homo sapiens (Human))
BDBM50235820
PNG
(CHEMBL4066664)
Show SMILES FC(F)(F)CNc1nc(Nc2ccc3cn[nH]c3c2)nc2ccoc12
PDB
MMDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



AbbVie Bioresearch Center

Curated by ChEMBL




Bioorg Med Chem Lett 26: 5562-5567 (2016)


Article DOI: 10.1016/j.bmcl.2016.09.077
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50235820
PNG
(CHEMBL4066664)
Show SMILES FC(F)(F)CNc1nc(Nc2ccc3cn[nH]c3c2)nc2ccoc12
PDB
MMDB

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n/an/a 97n/an/an/an/an/an/a



AbbVie Bioresearch Center

Curated by ChEMBL




Bioorg Med Chem Lett 26: 5562-5567 (2016)


Article DOI: 10.1016/j.bmcl.2016.09.077
More data for this
Ligand-Target Pair
CDK7/Cyclin H/MNAT1


(Homo sapiens (Human))
BDBM50235820
PNG
(CHEMBL4066664)
Show SMILES FC(F)(F)CNc1nc(Nc2ccc3cn[nH]c3c2)nc2ccoc12
PDB
MMDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



AbbVie Bioresearch Center

Curated by ChEMBL




Bioorg Med Chem Lett 26: 5562-5567 (2016)


Article DOI: 10.1016/j.bmcl.2016.09.077
More data for this
Ligand-Target Pair
G protein-coupled receptor kinase 5


(Homo sapiens (Human))
BDBM50235820
PNG
(CHEMBL4066664)
Show SMILES FC(F)(F)CNc1nc(Nc2ccc3cn[nH]c3c2)nc2ccoc12
PDB

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n/an/a 8.12E+3n/an/an/an/an/an/a



AbbVie Bioresearch Center

Curated by ChEMBL




Bioorg Med Chem Lett 26: 5562-5567 (2016)


Article DOI: 10.1016/j.bmcl.2016.09.077
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50235820
PNG
(CHEMBL4066664)
Show SMILES FC(F)(F)CNc1nc(Nc2ccc3cn[nH]c3c2)nc2ccoc12
PDB
MMDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



AbbVie Bioresearch Center

Curated by ChEMBL




Bioorg Med Chem Lett 26: 5562-5567 (2016)


Article DOI: 10.1016/j.bmcl.2016.09.077
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50235820
PNG
(CHEMBL4066664)
Show SMILES FC(F)(F)CNc1nc(Nc2ccc3cn[nH]c3c2)nc2ccoc12
PDB
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n/an/a 2.89E+3n/an/an/an/an/an/a



AbbVie Bioresearch Center

Curated by ChEMBL


Assay Description
The compound was tested for inhibition of purified rat hepatic squalene synthase in the presence of 1.2 mM NADPH and 1.0 mM inorganic pyrophosphate


Bioorg Med Chem Lett 26: 5562-5567 (2016)


Article DOI: 10.1016/j.bmcl.2016.09.077
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor


(Homo sapiens (Human))
BDBM50235820
PNG
(CHEMBL4066664)
Show SMILES FC(F)(F)CNc1nc(Nc2ccc3cn[nH]c3c2)nc2ccoc12
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n/an/a>1.00E+4n/an/an/an/an/an/a



AbbVie Bioresearch Center

Curated by ChEMBL




Bioorg Med Chem Lett 26: 5562-5567 (2016)


Article DOI: 10.1016/j.bmcl.2016.09.077
More data for this
Ligand-Target Pair
Activin receptor type-1


(Homo sapiens (Human))
BDBM50235820
PNG
(CHEMBL4066664)
Show SMILES FC(F)(F)CNc1nc(Nc2ccc3cn[nH]c3c2)nc2ccoc12
PDB

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UniChem
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n/an/a>1.00E+4n/an/an/an/an/an/a



AbbVie Bioresearch Center

Curated by ChEMBL




Bioorg Med Chem Lett 26: 5562-5567 (2016)


Article DOI: 10.1016/j.bmcl.2016.09.077
More data for this
Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1/Mitogen-activated protein kinase 1/RAF proto-oncogene serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM50235820
PNG
(CHEMBL4066664)
Show SMILES FC(F)(F)CNc1nc(Nc2ccc3cn[nH]c3c2)nc2ccoc12
PDB
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n/an/a>1.00E+4n/an/an/an/an/an/a



AbbVie Bioresearch Center

Curated by ChEMBL




Bioorg Med Chem Lett 26: 5562-5567 (2016)


Article DOI: 10.1016/j.bmcl.2016.09.077
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50235820
PNG
(CHEMBL4066664)
Show SMILES FC(F)(F)CNc1nc(Nc2ccc3cn[nH]c3c2)nc2ccoc12
PDB
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n/an/a>1.00E+4n/an/an/an/an/an/a



AbbVie Bioresearch Center

Curated by ChEMBL




Bioorg Med Chem Lett 26: 5562-5567 (2016)


Article DOI: 10.1016/j.bmcl.2016.09.077
More data for this
Ligand-Target Pair
Neurotrophic tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50235820
PNG
(CHEMBL4066664)
Show SMILES FC(F)(F)CNc1nc(Nc2ccc3cn[nH]c3c2)nc2ccoc12
PDB
MMDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



AbbVie Bioresearch Center

Curated by ChEMBL




Bioorg Med Chem Lett 26: 5562-5567 (2016)


Article DOI: 10.1016/j.bmcl.2016.09.077
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50235820
PNG
(CHEMBL4066664)
Show SMILES FC(F)(F)CNc1nc(Nc2ccc3cn[nH]c3c2)nc2ccoc12
PDB

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UniChem
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n/an/a 7.79E+3n/an/an/an/an/an/a



AbbVie Bioresearch Center

Curated by ChEMBL




Bioorg Med Chem Lett 26: 5562-5567 (2016)


Article DOI: 10.1016/j.bmcl.2016.09.077
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50235820
PNG
(CHEMBL4066664)
Show SMILES FC(F)(F)CNc1nc(Nc2ccc3cn[nH]c3c2)nc2ccoc12
PDB
MMDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



AbbVie Bioresearch Center

Curated by ChEMBL




Bioorg Med Chem Lett 26: 5562-5567 (2016)


Article DOI: 10.1016/j.bmcl.2016.09.077
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase NEK2


(Homo sapiens (Human))
BDBM50235820
PNG
(CHEMBL4066664)
Show SMILES FC(F)(F)CNc1nc(Nc2ccc3cn[nH]c3c2)nc2ccoc12
PDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



AbbVie Bioresearch Center

Curated by ChEMBL




Bioorg Med Chem Lett 26: 5562-5567 (2016)


Article DOI: 10.1016/j.bmcl.2016.09.077
More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (Human))
BDBM50235820
PNG
(CHEMBL4066664)
Show SMILES FC(F)(F)CNc1nc(Nc2ccc3cn[nH]c3c2)nc2ccoc12
PDB
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n/an/a 8.61E+3n/an/an/an/an/an/a



AbbVie Bioresearch Center

Curated by ChEMBL




Bioorg Med Chem Lett 26: 5562-5567 (2016)


Article DOI: 10.1016/j.bmcl.2016.09.077
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM50235820
PNG
(CHEMBL4066664)
Show SMILES FC(F)(F)CNc1nc(Nc2ccc3cn[nH]c3c2)nc2ccoc12
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n/an/a 5.02E+3n/an/an/an/an/an/a



AbbVie Bioresearch Center

Curated by ChEMBL




Bioorg Med Chem Lett 26: 5562-5567 (2016)


Article DOI: 10.1016/j.bmcl.2016.09.077
More data for this
Ligand-Target Pair
CAMK2A


(Homo sapiens (Human))
BDBM50235820
PNG
(CHEMBL4066664)
Show SMILES FC(F)(F)CNc1nc(Nc2ccc3cn[nH]c3c2)nc2ccoc12
PDB
MMDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



AbbVie Bioresearch Center

Curated by ChEMBL




Bioorg Med Chem Lett 26: 5562-5567 (2016)


Article DOI: 10.1016/j.bmcl.2016.09.077
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM50235820
PNG
(CHEMBL4066664)
Show SMILES FC(F)(F)CNc1nc(Nc2ccc3cn[nH]c3c2)nc2ccoc12
PDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



AbbVie Bioresearch Center

Curated by ChEMBL




Bioorg Med Chem Lett 26: 5562-5567 (2016)


Article DOI: 10.1016/j.bmcl.2016.09.077
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM50235820
PNG
(CHEMBL4066664)
Show SMILES FC(F)(F)CNc1nc(Nc2ccc3cn[nH]c3c2)nc2ccoc12
PDB

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PubMed
n/an/a 4.92E+3n/an/an/an/an/an/a



AbbVie Bioresearch Center

Curated by ChEMBL




Bioorg Med Chem Lett 26: 5562-5567 (2016)


Article DOI: 10.1016/j.bmcl.2016.09.077
More data for this
Ligand-Target Pair
Axin-1/Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM50235820
PNG
(CHEMBL4066664)
Show SMILES FC(F)(F)CNc1nc(Nc2ccc3cn[nH]c3c2)nc2ccoc12
PDB
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n/an/a>1.00E+4n/an/an/an/an/an/a



AbbVie Bioresearch Center

Curated by ChEMBL




Bioorg Med Chem Lett 26: 5562-5567 (2016)


Article DOI: 10.1016/j.bmcl.2016.09.077
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM50235820
PNG
(CHEMBL4066664)
Show SMILES FC(F)(F)CNc1nc(Nc2ccc3cn[nH]c3c2)nc2ccoc12
PDB
MMDB

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n/an/a 3.21E+3n/an/an/an/an/an/a



AbbVie Bioresearch Center

Curated by ChEMBL




Bioorg Med Chem Lett 26: 5562-5567 (2016)


Article DOI: 10.1016/j.bmcl.2016.09.077
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM50235820
PNG
(CHEMBL4066664)
Show SMILES FC(F)(F)CNc1nc(Nc2ccc3cn[nH]c3c2)nc2ccoc12
PDB
MMDB

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n/an/a 3.50E+3n/an/an/an/an/an/a



AbbVie Bioresearch Center

Curated by ChEMBL




Bioorg Med Chem Lett 26: 5562-5567 (2016)


Article DOI: 10.1016/j.bmcl.2016.09.077
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM50235820
PNG
(CHEMBL4066664)
Show SMILES FC(F)(F)CNc1nc(Nc2ccc3cn[nH]c3c2)nc2ccoc12
PDB
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n/an/a>1.00E+4n/an/an/an/an/an/a



AbbVie Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of specific [3H]propionyl-CCK-8 binding to rat cerebral cortex membrane Cholecystokinin type B receptor


Bioorg Med Chem Lett 26: 5562-5567 (2016)


Article DOI: 10.1016/j.bmcl.2016.09.077
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50235820
PNG
(CHEMBL4066664)
Show SMILES FC(F)(F)CNc1nc(Nc2ccc3cn[nH]c3c2)nc2ccoc12
PDB
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n/an/a>1.00E+4n/an/an/an/an/an/a



AbbVie Bioresearch Center

Curated by ChEMBL




Bioorg Med Chem Lett 26: 5562-5567 (2016)


Article DOI: 10.1016/j.bmcl.2016.09.077
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 8


(Homo sapiens (Human))
BDBM50235820
PNG
(CHEMBL4066664)
Show SMILES FC(F)(F)CNc1nc(Nc2ccc3cn[nH]c3c2)nc2ccoc12
PDB

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n/an/a 2.11E+3n/an/an/an/an/an/a



AbbVie Bioresearch Center

Curated by ChEMBL




Bioorg Med Chem Lett 26: 5562-5567 (2016)


Article DOI: 10.1016/j.bmcl.2016.09.077
More data for this
Ligand-Target Pair
JNK2/JNK3


(Homo sapiens (Human))
BDBM50235820
PNG
(CHEMBL4066664)
Show SMILES FC(F)(F)CNc1nc(Nc2ccc3cn[nH]c3c2)nc2ccoc12
PDB
MMDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



AbbVie Bioresearch Center

Curated by ChEMBL




Bioorg Med Chem Lett 26: 5562-5567 (2016)


Article DOI: 10.1016/j.bmcl.2016.09.077
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (Human))
BDBM50235820
PNG
(CHEMBL4066664)
Show SMILES FC(F)(F)CNc1nc(Nc2ccc3cn[nH]c3c2)nc2ccoc12
PDB

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PubMed
n/an/a 5.33E+3n/an/an/an/an/an/a



AbbVie Bioresearch Center

Curated by ChEMBL




Bioorg Med Chem Lett 26: 5562-5567 (2016)


Article DOI: 10.1016/j.bmcl.2016.09.077
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-1/alpha-3


(Homo sapiens (Human))
BDBM50235820
PNG
(CHEMBL4066664)
Show SMILES FC(F)(F)CNc1nc(Nc2ccc3cn[nH]c3c2)nc2ccoc12
PDB
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n/an/a 9.81E+3n/an/an/an/an/an/a



AbbVie Bioresearch Center

Curated by ChEMBL




Bioorg Med Chem Lett 26: 5562-5567 (2016)


Article DOI: 10.1016/j.bmcl.2016.09.077
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50235820
PNG
(CHEMBL4066664)
Show SMILES FC(F)(F)CNc1nc(Nc2ccc3cn[nH]c3c2)nc2ccoc12
PDB
MMDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



AbbVie Bioresearch Center

Curated by ChEMBL




Bioorg Med Chem Lett 26: 5562-5567 (2016)


Article DOI: 10.1016/j.bmcl.2016.09.077
More data for this
Ligand-Target Pair
Casein kinase I isoform alpha


(Homo sapiens (Human))
BDBM50235820
PNG
(CHEMBL4066664)
Show SMILES FC(F)(F)CNc1nc(Nc2ccc3cn[nH]c3c2)nc2ccoc12
PDB

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n/an/a 5.22E+3n/an/an/an/an/an/a



AbbVie Bioresearch Center

Curated by ChEMBL




Bioorg Med Chem Lett 26: 5562-5567 (2016)


Article DOI: 10.1016/j.bmcl.2016.09.077
More data for this
Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase; MEK1/2


(Homo sapiens (Human))
BDBM50235820
PNG
(CHEMBL4066664)
Show SMILES FC(F)(F)CNc1nc(Nc2ccc3cn[nH]c3c2)nc2ccoc12
PDB
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n/an/a>1.00E+4n/an/an/an/an/an/a



AbbVie Bioresearch Center

Curated by ChEMBL




Bioorg Med Chem Lett 26: 5562-5567 (2016)


Article DOI: 10.1016/j.bmcl.2016.09.077
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50235820
PNG
(CHEMBL4066664)
Show SMILES FC(F)(F)CNc1nc(Nc2ccc3cn[nH]c3c2)nc2ccoc12
PDB
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n/an/a 81n/an/an/an/an/an/a



AbbVie Bioresearch Center

Curated by ChEMBL




Bioorg Med Chem Lett 26: 5562-5567 (2016)


Article DOI: 10.1016/j.bmcl.2016.09.077
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 2


(Homo sapiens (Human))
BDBM50235820
PNG
(CHEMBL4066664)
Show SMILES FC(F)(F)CNc1nc(Nc2ccc3cn[nH]c3c2)nc2ccoc12
MMDB

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n/an/a 4.76E+3n/an/an/an/an/an/a



AbbVie Bioresearch Center

Curated by ChEMBL




Bioorg Med Chem Lett 26: 5562-5567 (2016)


Article DOI: 10.1016/j.bmcl.2016.09.077
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM50235820
PNG
(CHEMBL4066664)
Show SMILES FC(F)(F)CNc1nc(Nc2ccc3cn[nH]c3c2)nc2ccoc12
PDB
MMDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



AbbVie Bioresearch Center

Curated by ChEMBL




Bioorg Med Chem Lett 26: 5562-5567 (2016)


Article DOI: 10.1016/j.bmcl.2016.09.077
More data for this
Ligand-Target Pair
Focal adhesion kinase 1


(Homo sapiens (Human))
BDBM50235820
PNG
(CHEMBL4066664)
Show SMILES FC(F)(F)CNc1nc(Nc2ccc3cn[nH]c3c2)nc2ccoc12
PDB
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n/an/a>1.00E+4n/an/an/an/an/an/a



AbbVie Bioresearch Center

Curated by ChEMBL




Bioorg Med Chem Lett 26: 5562-5567 (2016)


Article DOI: 10.1016/j.bmcl.2016.09.077
More data for this
Ligand-Target Pair
Neurotrophic tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50235820
PNG
(CHEMBL4066664)
Show SMILES FC(F)(F)CNc1nc(Nc2ccc3cn[nH]c3c2)nc2ccoc12
PDB
MMDB

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n/an/a 5.24E+3n/an/an/an/an/an/a



AbbVie Bioresearch Center

Curated by ChEMBL




Bioorg Med Chem Lett 26: 5562-5567 (2016)


Article DOI: 10.1016/j.bmcl.2016.09.077
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50235820
PNG
(CHEMBL4066664)
Show SMILES FC(F)(F)CNc1nc(Nc2ccc3cn[nH]c3c2)nc2ccoc12
PDB

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n/an/a 7.63E+3n/an/an/an/an/an/a



AbbVie Bioresearch Center

Curated by ChEMBL




Bioorg Med Chem Lett 26: 5562-5567 (2016)


Article DOI: 10.1016/j.bmcl.2016.09.077
More data for this
Ligand-Target Pair
Death-associated protein kinase 3


(Homo sapiens (Human))
BDBM50235820
PNG
(CHEMBL4066664)
Show SMILES FC(F)(F)CNc1nc(Nc2ccc3cn[nH]c3c2)nc2ccoc12
PDB
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n/an/a 4.86E+3n/an/an/an/an/an/a



AbbVie Bioresearch Center

Curated by ChEMBL




Bioorg Med Chem Lett 26: 5562-5567 (2016)


Article DOI: 10.1016/j.bmcl.2016.09.077
More data for this
Ligand-Target Pair
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