BDBM50235823 CHEMBL4096597

SMILES: CC1(C)CCC(=O)Nc2cc(Nc3nc(NCC(F)(F)F)c4occc4n3)ccc12

InChI Key: InChIKey=GTBHCHNISMHJKA-UHFFFAOYSA-N

Data: 1 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50235823   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM50235823 (CHEMBL4096597) Show SMILES CC1(C)CCC(=O)Nc2cc(Nc3nc(NCC(F)(F)F)c4occc4n3)ccc12 Show InChI InChI=1S/C20H20F3N5O2/c1-19(2)7-5-15(29)26-14-9-11(3-4-12(14)19)25-18-27-13-6-8-30-16(13)17(28-18)24-10-20(21,22)23/h3-4,6,8-9H,5,7,10H2,1-2H3,(H,26,29)(H2,24,25,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	49	n/a	n/a	n/a	n/a
AbbVie Bioresearch Center Curated by ChEMBL					Assay Description Inhibition of Syk in human Ramos B cells assessed as decrease in intracellular calcium flux measured for 3.5 mins by calcium-5 dye based FLIPR assay				Bioorg Med Chem Lett 26: 5562-5567 (2016) Article DOI: 10.1016/j.bmcl.2016.09.077 BindingDB Entry DOI: 10.7270/Q2WQ061V
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM50235823 (CHEMBL4096597) Show SMILES CC1(C)CCC(=O)Nc2cc(Nc3nc(NCC(F)(F)F)c4occc4n3)ccc12 Show InChI InChI=1S/C20H20F3N5O2/c1-19(2)7-5-15(29)26-14-9-11(3-4-12(14)19)25-18-27-13-6-8-30-16(13)17(28-18)24-10-20(21,22)23/h3-4,6,8-9H,5,7,10H2,1-2H3,(H,26,29)(H2,24,25,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	43	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Bioresearch Center Curated by ChEMBL					Assay Description Inhibition of C-terminal His-tagged Syk catalytic domain (356 to 635 residues) (unknown origin) using biotin-TYR1 as substrate after 60 mins by TR-FR...				Bioorg Med Chem Lett 26: 5562-5567 (2016) Article DOI: 10.1016/j.bmcl.2016.09.077 BindingDB Entry DOI: 10.7270/Q2WQ061V
					More data for this Ligand-Target Pair