BDBM50235834 CHEMBL4088907

SMILES: FC(F)(F)CNc1nc(Nc2ccc3CCC(=O)Nc3c2)nc2ccoc12

InChI Key: InChIKey=WSFYPKMMFQPXHF-UHFFFAOYSA-N

Data: 1 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50235834   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM50235834 (CHEMBL4088907) Show SMILES FC(F)(F)CNc1nc(Nc2ccc3CCC(=O)Nc3c2)nc2ccoc12 Show InChI InChI=1S/C17H14F3N5O2/c18-17(19,20)8-21-15-14-11(5-6-27-14)24-16(25-15)22-10-3-1-9-2-4-13(26)23-12(9)7-10/h1,3,5-7H,2,4,8H2,(H,23,26)(H2,21,22,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	63	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Bioresearch Center Curated by ChEMBL					Assay Description Inhibition of C-terminal His-tagged Syk catalytic domain (356 to 635 residues) (unknown origin) using biotin-TYR1 as substrate after 60 mins by TR-FR...				Bioorg Med Chem Lett 26: 5562-5567 (2016) Article DOI: 10.1016/j.bmcl.2016.09.077 BindingDB Entry DOI: 10.7270/Q2WQ061V
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM50235834 (CHEMBL4088907) Show SMILES FC(F)(F)CNc1nc(Nc2ccc3CCC(=O)Nc3c2)nc2ccoc12 Show InChI InChI=1S/C17H14F3N5O2/c18-17(19,20)8-21-15-14-11(5-6-27-14)24-16(25-15)22-10-3-1-9-2-4-13(26)23-12(9)7-10/h1,3,5-7H,2,4,8H2,(H,23,26)(H2,21,22,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	101	n/a	n/a	n/a	n/a
AbbVie Bioresearch Center Curated by ChEMBL					Assay Description Inhibitory concentration against cyclin dependent kinase-2 (CDK2)/Cyclin E				Bioorg Med Chem Lett 26: 5562-5567 (2016) Article DOI: 10.1016/j.bmcl.2016.09.077 BindingDB Entry DOI: 10.7270/Q2WQ061V
					More data for this Ligand-Target Pair