BDBM50235992 CHEMBL4093147

SMILES: Fc1ccccc1-c1cc(C#N)c(NCc2ccco2)n2cnnc12

InChI Key: InChIKey=XONOYNOZMFMROO-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50235992   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Polycomb protein EED (Homo sapiens (Human))	BDBM50235992 (CHEMBL4093147) Show SMILES Fc1ccccc1-c1cc(C#N)c(NCc2ccco2)n2cnnc12 Show InChI InChI=1S/C18H12FN5O/c19-16-6-2-1-5-14(16)15-8-12(9-20)17(24-11-22-23-18(15)24)21-10-13-4-3-7-25-13/h1-8,11,21H,10H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of EED in human G401 cells assessed as reduction in global H3K27me3 level after 48 hrs by ELISA				J Med Chem 60: 2215-2226 (2017) Article DOI: 10.1021/acs.jmedchem.6b01576 BindingDB Entry DOI: 10.7270/Q20G3NDT
					More data for this Ligand-Target Pair
Polycomb protein EED (Homo sapiens (Human))	BDBM50235992 (CHEMBL4093147) Show SMILES Fc1ccccc1-c1cc(C#N)c(NCc2ccco2)n2cnnc12 Show InChI InChI=1S/C18H12FN5O/c19-16-6-2-1-5-14(16)15-8-12(9-20)17(24-11-22-23-18(15)24)21-10-13-4-3-7-25-13/h1-8,11,21H,10H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	210	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Agonist activity was determined against hPR (human progesterone receptor) compared to that of progesterone (100%)				J Med Chem 60: 2215-2226 (2017) Article DOI: 10.1021/acs.jmedchem.6b01576 BindingDB Entry DOI: 10.7270/Q20G3NDT
					More data for this Ligand-Target Pair