BDBM50236009 CHEMBL4104753

SMILES: CN(C)Cc1ccc(cc1)-c1cnc(NCc2ccc(F)s2)n2cnnc12

InChI Key: InChIKey=LMFWMBVAUJYDPA-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50236009   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Polycomb protein EED (Homo sapiens (Human))	BDBM50236009 (CHEMBL4104753) Show SMILES CN(C)Cc1ccc(cc1)-c1cnc(NCc2ccc(F)s2)n2cnnc12 Show InChI InChI=1S/C19H19FN6S/c1-25(2)11-13-3-5-14(6-4-13)16-10-22-19(26-12-23-24-18(16)26)21-9-15-7-8-17(20)27-15/h3-8,10,12H,9,11H2,1-2H3,(H,21,22)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of recombinant N-terminal GST-tagged EED (76 to 441 residues) (unknown origin) expressed in Escherichia coli BL21-CodonPlus(DE3)-RIL asses...				J Med Chem 60: 2215-2226 (2017) Article DOI: 10.1021/acs.jmedchem.6b01576 BindingDB Entry DOI: 10.7270/Q20G3NDT
					More data for this Ligand-Target Pair