BDBM50236018 CHEMBL4079016

SMILES: CN(C)Cc1ccc(cc1)-c1cc(C#N)c(NCc2sccc2C)n2cnnc12

InChI Key: InChIKey=BVYSRBICAFJOOB-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50236018   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
EZH2/SUZ12/EED/RBBP7/RBBP4 (Homo sapiens (Human))	BDBM50236018 (CHEMBL4079016) Show SMILES CN(C)Cc1ccc(cc1)-c1cc(C#N)c(NCc2sccc2C)n2cnnc12 Show InChI InChI=1S/C22H22N6S/c1-15-8-9-29-20(15)12-24-21-18(11-23)10-19(22-26-25-14-28(21)22)17-6-4-16(5-7-17)13-27(2)3/h4-10,14,24H,12-13H2,1-3H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.18E+4	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of recombinant N-terminal GST-tagged EED (76 to 441 residues) (unknown origin) expressed in Escherichia coli BL21-CodonPlus(DE3)-RIL asses...				J Med Chem 60: 2215-2226 (2017) Article DOI: 10.1021/acs.jmedchem.6b01576 BindingDB Entry DOI: 10.7270/Q20G3NDT
					More data for this Ligand-Target Pair