BDBM50236263 19-methyl-7-[(1E)-1-[(2-methylpropoxy)imino]ethyl]-3-(propan-2-yl)-3,13,19,20-tetraazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,21}]tricosa-1(16),2(10),4,6,8,11(15),17,20-octaen-14-one::CHEMBL258436

SMILES: CC(C)CO\N=C(/C)c1ccc2n(C(C)C)c3c4CCc5nn(C)cc5-c4c4C(=O)NCc4c3c2c1

InChI Key: InChIKey=WBNNWMOEDXYOBE-VTNSRFBWSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50236263   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50236263 (19-methyl-7-[(1E)-1-[(2-methylpropoxy)imino]ethyl]...) Show SMILES CC(C)CO\N=C(/C)c1ccc2n(C(C)C)c3c4CCc5nn(C)cc5-c4c4C(=O)NCc4c3c2c1 Show InChI InChI=1S/C29H33N5O2/c1-15(2)14-36-32-17(5)18-7-10-24-20(11-18)26-21-12-30-29(35)27(21)25-19(28(26)34(24)16(3)4)8-9-23-22(25)13-33(6)31-23/h7,10-11,13,15-16H,8-9,12,14H2,1-6H3,(H,30,35)/b32-17+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	51	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of human recombinant VEGFR2 by HTRF assay				Bioorg Med Chem Lett 18: 1916-21 (2008) Article DOI: 10.1016/j.bmcl.2008.02.001 BindingDB Entry DOI: 10.7270/Q27M07PV
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50236263 (19-methyl-7-[(1E)-1-[(2-methylpropoxy)imino]ethyl]...) Show SMILES CC(C)CO\N=C(/C)c1ccc2n(C(C)C)c3c4CCc5nn(C)cc5-c4c4C(=O)NCc4c3c2c1 Show InChI InChI=1S/C29H33N5O2/c1-15(2)14-36-32-17(5)18-7-10-24-20(11-18)26-21-12-30-29(35)27(21)25-19(28(26)34(24)16(3)4)8-9-23-22(25)13-33(6)31-23/h7,10-11,13,15-16H,8-9,12,14H2,1-6H3,(H,30,35)/b32-17+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of VEGF-stimulated VEGFR2 autophosphorylation in HUVEC cells at 50 nM relative to control				Bioorg Med Chem Lett 18: 1916-21 (2008) Article DOI: 10.1016/j.bmcl.2008.02.001 BindingDB Entry DOI: 10.7270/Q27M07PV
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor (Homo sapiens (Human))	BDBM50236263 (19-methyl-7-[(1E)-1-[(2-methylpropoxy)imino]ethyl]...) Show SMILES CC(C)CO\N=C(/C)c1ccc2n(C(C)C)c3c4CCc5nn(C)cc5-c4c4C(=O)NCc4c3c2c1 Show InChI InChI=1S/C29H33N5O2/c1-15(2)14-36-32-17(5)18-7-10-24-20(11-18)26-21-12-30-29(35)27(21)25-19(28(26)34(24)16(3)4)8-9-23-22(25)13-33(6)31-23/h7,10-11,13,15-16H,8-9,12,14H2,1-6H3,(H,30,35)/b32-17+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	46	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of human recombinant TIE2 by HTRF assay				Bioorg Med Chem Lett 18: 1916-21 (2008) Article DOI: 10.1016/j.bmcl.2008.02.001 BindingDB Entry DOI: 10.7270/Q27M07PV
					More data for this Ligand-Target Pair