BDBM50236271 CHEMBL4103411

SMILES: Cc1cc(C2CN(CC(F)(F)C2)C(=O)c2ccc3ccccc3c2)n2ncnc2n1

InChI Key: InChIKey=UPRBEZUZBRFEOC-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50236271   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Homo sapiens phosphodiesterase 2A (PDE2A) (Homo sapiens (Human))	BDBM50236271 (CHEMBL4103411) Show SMILES Cc1cc(C2CN(CC(F)(F)C2)C(=O)c2ccc3ccccc3c2)n2ncnc2n1 Show InChI InChI=1S/C22H19F2N5O/c1-14-8-19(29-21(27-14)25-13-26-29)18-10-22(23,24)12-28(11-18)20(30)17-7-6-15-4-2-3-5-16(15)9-17/h2-9,13,18H,10-12H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Dart Neuroscience LLC Curated by ChEMBL					Assay Description Inhibition of human full length GST-tagged PDE2a using FAM-labeled cAMP as substrate preincubated for 5 mins followed by substrate addition measured ...				J Med Chem 60: 2037-2051 (2017) Article DOI: 10.1021/acs.jmedchem.6b01793 BindingDB Entry DOI: 10.7270/Q2Q242GF
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