BDBM50236294 1-(2-(5-cyano-2-(4-fluorophenyl)-1H-indol-3-yl)ethyl)-3-(methylsulfonyl)urea::CHEMBL254569

SMILES: CS(=O)(=O)NC(=O)NCCc1c([nH]c2ccc(cc12)C#N)-c1ccc(F)cc1

InChI Key: InChIKey=AMPDDZBKINMTEI-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50236294   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
C-X-C chemokine receptor type 2 (Homo sapiens (Human))	BDBM50236294 (1-(2-(5-cyano-2-(4-fluorophenyl)-1H-indol-3-yl)eth...) Show SMILES CS(=O)(=O)NC(=O)NCCc1c([nH]c2ccc(cc12)C#N)-c1ccc(F)cc1 Show InChI InChI=1S/C19H17FN4O3S/c1-28(26,27)24-19(25)22-9-8-15-16-10-12(11-21)2-7-17(16)23-18(15)13-3-5-14(20)6-4-13/h2-7,10,23H,8-9H2,1H3,(H2,22,24,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	640	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Displacement of europium labeled-human IL8 from human cloned CXCR2 expressed in Sf9 membrane with Galphai3-beta-1-gamma-2 by DELFIA binding assay				Bioorg Med Chem Lett 18: 1926-30 (2008) Article DOI: 10.1016/j.bmcl.2008.01.127 BindingDB Entry DOI: 10.7270/Q20P10V3
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