BDBM50236308 4-(5-cyano-2-(4-fluorophenyl)-1H-indol-3-yl)-N-(morpholinosulfonyl)butanamide::CHEMBL254366

SMILES: Fc1ccc(cc1)-c1[nH]c2ccc(cc2c1CCCC(=O)NS(=O)(=O)N1CCOCC1)C#N

InChI Key: InChIKey=OTHPPVLCKCFVAW-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50236308   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
C-X-C chemokine receptor type 2 (Homo sapiens (Human))	BDBM50236308 (4-(5-cyano-2-(4-fluorophenyl)-1H-indol-3-yl)-N-(mo...) Show SMILES Fc1ccc(cc1)-c1[nH]c2ccc(cc2c1CCCC(=O)NS(=O)(=O)N1CCOCC1)C#N Show InChI InChI=1S/C23H23FN4O4S/c24-18-7-5-17(6-8-18)23-19(20-14-16(15-25)4-9-21(20)26-23)2-1-3-22(29)27-33(30,31)28-10-12-32-13-11-28/h4-9,14,26H,1-3,10-13H2,(H,27,29)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Displacement of europium labeled-human IL8 from human cloned CXCR2 expressed in Sf9 membrane with Galphai3-beta-1-gamma-2 by DELFIA binding assay				Bioorg Med Chem Lett 18: 1926-30 (2008) Article DOI: 10.1016/j.bmcl.2008.01.127 BindingDB Entry DOI: 10.7270/Q20P10V3
					More data for this Ligand-Target Pair