BDBM50236313 4-(5-cyano-2-(4-fluorophenyl)-1H-indol-3-yl)-N-methyl-N-(methylsulfonyl)butanamide::CHEMBL258419

SMILES: CN(C(=O)CCCc1c([nH]c2ccc(cc12)C#N)-c1ccc(F)cc1)S(C)(=O)=O

InChI Key: InChIKey=FFOMDIJZKUMUMF-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50236313   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
C-X-C chemokine receptor type 2 (Homo sapiens (Human))	BDBM50236313 (4-(5-cyano-2-(4-fluorophenyl)-1H-indol-3-yl)-N-met...) Show SMILES CN(C(=O)CCCc1c([nH]c2ccc(cc12)C#N)-c1ccc(F)cc1)S(C)(=O)=O Show InChI InChI=1S/C21H20FN3O3S/c1-25(29(2,27)28)20(26)5-3-4-17-18-12-14(13-23)6-11-19(18)24-21(17)15-7-9-16(22)10-8-15/h6-12,24H,3-5H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Displacement of europium labeled-human IL8 from human cloned CXCR2 expressed in Sf9 membrane with Galphai3-beta-1-gamma-2 by DELFIA binding assay				Bioorg Med Chem Lett 18: 1926-30 (2008) Article DOI: 10.1016/j.bmcl.2008.01.127 BindingDB Entry DOI: 10.7270/Q20P10V3
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