Found 8 hits for monomerid = 50237424 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Sphingosine kinase 1 (SPHK1)
(Homo sapiens (Human)) | BDBM50237424
(CHEMBL4101573)Show SMILES Cc1cc(CS(=O)(=O)c2ccccc2)cc(OCc2ccc3[nH]c(N)nc3c2)c1 Show InChI InChI=1S/C22H21N3O3S/c1-15-9-17(14-29(26,27)19-5-3-2-4-6-19)11-18(10-15)28-13-16-7-8-20-21(12-16)25-22(23)24-20/h2-12H,13-14H2,1H3,(H3,23,24,25) | PDB
UniProtKB/SwissProt UniProtKB/TrEMBL
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of human C-terminal His6-tagged SPHK1 expressed in fall armyworm sf9 cells assessed as reduction in S1P formation using sphingosine as sub... |
J Med Chem 60: 2562-2572 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00070 BindingDB Entry DOI: 10.7270/Q27P91PG |
More data for this Ligand-Target Pair | |
Sphingosine kinase 1 (SPHK1)
(Homo sapiens (Human)) | BDBM50237424
(CHEMBL4101573)Show SMILES Cc1cc(CS(=O)(=O)c2ccccc2)cc(OCc2ccc3[nH]c(N)nc3c2)c1 Show InChI InChI=1S/C22H21N3O3S/c1-15-9-17(14-29(26,27)19-5-3-2-4-6-19)11-18(10-15)28-13-16-7-8-20-21(12-16)25-22(23)24-20/h2-12H,13-14H2,1H3,(H3,23,24,25) | PDB
UniProtKB/SwissProt UniProtKB/TrEMBL
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of SPHK1 in human MDA1483 cells using C17-sphingosine as substrate assessed as reduction in C17-S1P formation preincubated for 30 mins wit... |
J Med Chem 60: 2562-2572 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00070 BindingDB Entry DOI: 10.7270/Q27P91PG |
More data for this Ligand-Target Pair | |
Sphingosine 1-phosphate receptor 1
(Homo sapiens (Human)) | BDBM50237424
(CHEMBL4101573)Show SMILES Cc1cc(CS(=O)(=O)c2ccccc2)cc(OCc2ccc3[nH]c(N)nc3c2)c1 Show InChI InChI=1S/C22H21N3O3S/c1-15-9-17(14-29(26,27)19-5-3-2-4-6-19)11-18(10-15)28-13-16-7-8-20-21(12-16)25-22(23)24-20/h2-12H,13-14H2,1H3,(H3,23,24,25) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Binding affinity to S1PR1 (unknown origin) |
J Med Chem 60: 2562-2572 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00070 BindingDB Entry DOI: 10.7270/Q27P91PG |
More data for this Ligand-Target Pair | |
Sphingosine 1-phosphate receptor 5
(Homo sapiens (Human)) | BDBM50237424
(CHEMBL4101573)Show SMILES Cc1cc(CS(=O)(=O)c2ccccc2)cc(OCc2ccc3[nH]c(N)nc3c2)c1 Show InChI InChI=1S/C22H21N3O3S/c1-15-9-17(14-29(26,27)19-5-3-2-4-6-19)11-18(10-15)28-13-16-7-8-20-21(12-16)25-22(23)24-20/h2-12H,13-14H2,1H3,(H3,23,24,25) | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Binding affinity to S1PR5 (unknown origin) |
J Med Chem 60: 2562-2572 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00070 BindingDB Entry DOI: 10.7270/Q27P91PG |
More data for this Ligand-Target Pair | |
Sphingosine 1-phosphate receptor 3
(Homo sapiens (Human)) | BDBM50237424
(CHEMBL4101573)Show SMILES Cc1cc(CS(=O)(=O)c2ccccc2)cc(OCc2ccc3[nH]c(N)nc3c2)c1 Show InChI InChI=1S/C22H21N3O3S/c1-15-9-17(14-29(26,27)19-5-3-2-4-6-19)11-18(10-15)28-13-16-7-8-20-21(12-16)25-22(23)24-20/h2-12H,13-14H2,1H3,(H3,23,24,25) | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Binding affinity to S1PR3 (unknown origin) |
J Med Chem 60: 2562-2572 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00070 BindingDB Entry DOI: 10.7270/Q27P91PG |
More data for this Ligand-Target Pair | |
Sphingosine kinase 1 (SPHK1)
(Homo sapiens (Human)) | BDBM50237424
(CHEMBL4101573)Show SMILES Cc1cc(CS(=O)(=O)c2ccccc2)cc(OCc2ccc3[nH]c(N)nc3c2)c1 Show InChI InChI=1S/C22H21N3O3S/c1-15-9-17(14-29(26,27)19-5-3-2-4-6-19)11-18(10-15)28-13-16-7-8-20-21(12-16)25-22(23)24-20/h2-12H,13-14H2,1H3,(H3,23,24,25) | PDB
UniProtKB/SwissProt UniProtKB/TrEMBL
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of human progesterone receptor activation in T47D human breast cancer cell. |
J Med Chem 60: 2562-2572 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00070 BindingDB Entry DOI: 10.7270/Q27P91PG |
More data for this Ligand-Target Pair | |
Sphingosine kinase types 2 (SphK2)
(Homo sapiens (Human)) | BDBM50237424
(CHEMBL4101573)Show SMILES Cc1cc(CS(=O)(=O)c2ccccc2)cc(OCc2ccc3[nH]c(N)nc3c2)c1 Show InChI InChI=1S/C22H21N3O3S/c1-15-9-17(14-29(26,27)19-5-3-2-4-6-19)11-18(10-15)28-13-16-7-8-20-21(12-16)25-22(23)24-20/h2-12H,13-14H2,1H3,(H3,23,24,25) | UniProtKB/SwissProt UniProtKB/TrEMBL
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.96E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of SPHK2 (unknown origin) by FITC-based caliper assay |
J Med Chem 60: 2562-2572 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00070 BindingDB Entry DOI: 10.7270/Q27P91PG |
More data for this Ligand-Target Pair | |
Sphingosine 1-phosphate receptor 1
(Homo sapiens (Human)) | BDBM50237424
(CHEMBL4101573)Show SMILES Cc1cc(CS(=O)(=O)c2ccccc2)cc(OCc2ccc3[nH]c(N)nc3c2)c1 Show InChI InChI=1S/C22H21N3O3S/c1-15-9-17(14-29(26,27)19-5-3-2-4-6-19)11-18(10-15)28-13-16-7-8-20-21(12-16)25-22(23)24-20/h2-12H,13-14H2,1H3,(H3,23,24,25) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Binding affinity to S1PR2 (unknown origin) |
J Med Chem 60: 2562-2572 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00070 BindingDB Entry DOI: 10.7270/Q27P91PG |
More data for this Ligand-Target Pair | |