Found 5 hits for monomerid = 50237553 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50237553
(CHEMBL4071058)Show SMILES CC(C)(C)OC(=O)NCC(=O)Nc1ccc2ncnc(Nc3cccc(Br)c3)c2c1 Show InChI InChI=1S/C21H22BrN5O3/c1-21(2,3)30-20(29)23-11-18(28)26-15-7-8-17-16(10-15)19(25-12-24-17)27-14-6-4-5-13(22)9-14/h4-10,12H,11H2,1-3H3,(H,23,29)(H,26,28)(H,24,25,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.87E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Xuzhou Medical University
Curated by ChEMBL
| Assay Description
Inhibition of VEGFR2 (unknown origin) measured after 40 mins by Kinase Glo luminescence assay |
Eur J Med Chem 130: 393-405 (2017)
Article DOI: 10.1016/j.ejmech.2017.02.061
BindingDB Entry DOI: 10.7270/Q21Z46PJ |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50237553
(CHEMBL4071058)Show SMILES CC(C)(C)OC(=O)NCC(=O)Nc1ccc2ncnc(Nc3cccc(Br)c3)c2c1 Show InChI InChI=1S/C21H22BrN5O3/c1-21(2,3)30-20(29)23-11-18(28)26-15-7-8-17-16(10-15)19(25-12-24-17)27-14-6-4-5-13(22)9-14/h4-10,12H,11H2,1-3H3,(H,23,29)(H,26,28)(H,24,25,27) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 3.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Xuzhou Medical University
Curated by ChEMBL
| Assay Description
Inhibition of EGFR (unknown origin) measured after 40 mins by Kinase Glo luminescence assay |
Eur J Med Chem 130: 393-405 (2017)
Article DOI: 10.1016/j.ejmech.2017.02.061
BindingDB Entry DOI: 10.7270/Q21Z46PJ |
More data for this
Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50237553
(CHEMBL4071058)Show SMILES CC(C)(C)OC(=O)NCC(=O)Nc1ccc2ncnc(Nc3cccc(Br)c3)c2c1 Show InChI InChI=1S/C21H22BrN5O3/c1-21(2,3)30-20(29)23-11-18(28)26-15-7-8-17-16(10-15)19(25-12-24-17)27-14-6-4-5-13(22)9-14/h4-10,12H,11H2,1-3H3,(H,23,29)(H,26,28)(H,24,25,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.73E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Xuzhou Medical University
Curated by ChEMBL
| Assay Description
Inhibition of [3H]AVP binding to recombinant human vasopressin V2 receptor |
Eur J Med Chem 130: 393-405 (2017)
Article DOI: 10.1016/j.ejmech.2017.02.061
BindingDB Entry DOI: 10.7270/Q21Z46PJ |
More data for this
Ligand-Target Pair | |
Aurora kinase B
(Homo sapiens (Human)) | BDBM50237553
(CHEMBL4071058)Show SMILES CC(C)(C)OC(=O)NCC(=O)Nc1ccc2ncnc(Nc3cccc(Br)c3)c2c1 Show InChI InChI=1S/C21H22BrN5O3/c1-21(2,3)30-20(29)23-11-18(28)26-15-7-8-17-16(10-15)19(25-12-24-17)27-14-6-4-5-13(22)9-14/h4-10,12H,11H2,1-3H3,(H,23,29)(H,26,28)(H,24,25,27) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 6.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Xuzhou Medical University
Curated by ChEMBL
| Assay Description
Inhibition of Aurora B (unknown origin) measured after 40 mins by Kinase Glo luminescence assay |
Eur J Med Chem 130: 393-405 (2017)
Article DOI: 10.1016/j.ejmech.2017.02.061
BindingDB Entry DOI: 10.7270/Q21Z46PJ |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50237553
(CHEMBL4071058)Show SMILES CC(C)(C)OC(=O)NCC(=O)Nc1ccc2ncnc(Nc3cccc(Br)c3)c2c1 Show InChI InChI=1S/C21H22BrN5O3/c1-21(2,3)30-20(29)23-11-18(28)26-15-7-8-17-16(10-15)19(25-12-24-17)27-14-6-4-5-13(22)9-14/h4-10,12H,11H2,1-3H3,(H,23,29)(H,26,28)(H,24,25,27) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Xuzhou Medical University
Curated by ChEMBL
| Assay Description
Inhibition of c-MET (unknown origin) measured after 40 mins by Kinase Glo luminescence assay |
Eur J Med Chem 130: 393-405 (2017)
Article DOI: 10.1016/j.ejmech.2017.02.061
BindingDB Entry DOI: 10.7270/Q21Z46PJ |
More data for this
Ligand-Target Pair | |
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