BDBM50238249 CHEMBL4068741

SMILES: [H][C@@]12C[C@]1([H])[C@H](N(C2)C(=O)Nc1cn(C(N)=O)c2ccccc12)C(=O)Nc1cccc(OC(F)(F)F)c1

InChI Key: InChIKey=UGKHRGQDGMSGON-UVIMBBFXSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50238249   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Complement factor D (Homo sapiens (Human))	BDBM50238249 (CHEMBL4068741) Show SMILES [H][C@@]12C[C@]1([H])[C@H](N(C2)C(=O)Nc1cn(C(N)=O)c2ccccc12)C(=O)Nc1cccc(OC(F)(F)F)c1 |r| Show InChI InChI=1S/C23H20F3N5O4/c24-23(25,26)35-14-5-3-4-13(9-14)28-20(32)19-16-8-12(16)10-31(19)22(34)29-17-11-30(21(27)33)18-7-2-1-6-15(17)18/h1-7,9,11-12,16,19H,8,10H2,(H2,27,33)(H,28,32)(H,29,34)/t12-,16-,19-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	650	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Pharma AG Curated by ChEMBL					Assay Description Inhibition of recombinant human complement factor D catalytic domain using Z-Lys-thiobenzylester as substrate preincubated for 1 hr followed by subst...				J Med Chem 60: 5717-5735 (2017) Article DOI: 10.1021/acs.jmedchem.7b00425 BindingDB Entry DOI: 10.7270/Q2TB195V
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