BDBM50238250 CHEMBL4075355

SMILES: [H][C@]12C[C@@]1([H])N([C@@H](C2)C(=O)Nc1cccc(OC(F)F)c1)C(=O)Nc1cn(C(N)=O)c2ccccc12

InChI Key: InChIKey=UCPZLYBMWTUYQE-DPMMWBKBSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50238250   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Complement factor D (Homo sapiens (Human))	BDBM50238250 (CHEMBL4075355) Show SMILES [H][C@]12C[C@@]1([H])N([C@@H](C2)C(=O)Nc1cccc(OC(F)F)c1)C(=O)Nc1cn(C(N)=O)c2ccccc12 |r| Show InChI InChI=1S/C23H21F2N5O4/c24-21(25)34-14-5-3-4-13(10-14)27-20(31)19-9-12-8-18(12)30(19)23(33)28-16-11-29(22(26)32)17-7-2-1-6-15(16)17/h1-7,10-12,18-19,21H,8-9H2,(H2,26,32)(H,27,31)(H,28,33)/t12-,18-,19+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Pharma AG Curated by ChEMBL					Assay Description Inhibition of recombinant human complement factor D catalytic domain using Z-Lys-thiobenzylester as substrate preincubated for 1 hr followed by subst...				J Med Chem 60: 5717-5735 (2017) Article DOI: 10.1021/acs.jmedchem.7b00425 BindingDB Entry DOI: 10.7270/Q2TB195V
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