BindingDB PrimarySearch

BDBM50238541 CHEMBL4092336

SMILES: COC(=O)c1ccccc1NC(=O)CSc1nc2cc(OC)ccc2[nH]1

InChI Key: InChIKey=GZBULYAKSCNNPA-UHFFFAOYSA-N

Data: 14 IC50 1 Kd

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50238541
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Protein arginine methyltransferase 7 (PRMT7) (Homo sapiens (Human))	BDBM50238541 (CHEMBL4092336) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Shandong University Curated by ChEMBL					Assay Description Inhibition of recombinant human N-terminal His-tagged full length PRMT7 expressed in baculovirus using of histone H4 as substrate preincubated for 15...				J Med Chem 60: 6289-6304 (2017) Article DOI: 10.1021/acs.jmedchem.7b00587 BindingDB Entry DOI: 10.7270/Q2D220XW
Shandong University Curated by ChEMBL					More data for this Ligand-Target Pair
Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM50238541 (CHEMBL4092336) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	330	n/a	n/a	n/a	n/a	n/a	n/a
University of Jinan Curated by ChEMBL					Assay Description Inhibition of PRMT5 (unknown origin)				Bioorg Med Chem Lett 28: 3693-3699 (2018) Article DOI: 10.1016/j.bmcl.2018.10.026
University of Jinan Curated by ChEMBL					More data for this Ligand-Target Pair
Histone-arginine methyltransferase CARM1 (Homo sapiens (Human))	BDBM50238541 (CHEMBL4092336) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Shandong University Curated by ChEMBL					Assay Description Inhibition of human kidney renin				J Med Chem 60: 6289-6304 (2017) Article DOI: 10.1021/acs.jmedchem.7b00587 BindingDB Entry DOI: 10.7270/Q2D220XW
Shandong University Curated by ChEMBL					More data for this Ligand-Target Pair
Protein arginine N-methyltransferase 6 (Homo sapiens (Human))	BDBM50238541 (CHEMBL4092336) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Shandong University Curated by ChEMBL					Assay Description Inhibition of recombinant human N-terminal His-tagged PRMT6 (2 to 375 residues) expressed in Escherichia coli using of histone H3 as substrate preinc...				J Med Chem 60: 6289-6304 (2017) Article DOI: 10.1021/acs.jmedchem.7b00587 BindingDB Entry DOI: 10.7270/Q2D220XW
Shandong University Curated by ChEMBL					More data for this Ligand-Target Pair
Protein arginine N-methyltransferase 8 (Homo sapiens (Human))	BDBM50238541 (CHEMBL4092336) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Shandong University Curated by ChEMBL					Assay Description Inhibition of recombinant human N-terminal FLAG-tagged PRMT8 (61 to 394 residues) expressed in baculovirus infected Sf9 cell expression system using ...				J Med Chem 60: 6289-6304 (2017) Article DOI: 10.1021/acs.jmedchem.7b00587 BindingDB Entry DOI: 10.7270/Q2D220XW
Shandong University Curated by ChEMBL					More data for this Ligand-Target Pair
Nuclear SET domain-containing protein 1 (NSD1) (Homo sapiens (Human))	BDBM50238541 (CHEMBL4092336) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Shandong University Curated by ChEMBL					Assay Description Inhibition of NSD1 (unknown origin) preincubated for 15 mins followed by [3H]-SAM addition measured after 4 hrs by liquid scintillation counting				J Med Chem 60: 6289-6304 (2017) Article DOI: 10.1021/acs.jmedchem.7b00587 BindingDB Entry DOI: 10.7270/Q2D220XW
Shandong University Curated by ChEMBL					More data for this Ligand-Target Pair
DNA (cytosine-5)-methyltransferase 1 (DNMT1) (Homo sapiens (Human))	BDBM50238541 (CHEMBL4092336) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Shandong University Curated by ChEMBL					Assay Description Inhibition of 5-HT uptake in rat synaptosomal fraction				J Med Chem 60: 6289-6304 (2017) Article DOI: 10.1021/acs.jmedchem.7b00587 BindingDB Entry DOI: 10.7270/Q2D220XW
Shandong University Curated by ChEMBL					More data for this Ligand-Target Pair
SET domain-containing protein 7/9 (Set7/9) (Homo sapiens (Human))	BDBM50238541 (CHEMBL4092336) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Shandong University Curated by ChEMBL					Assay Description Inhibition of SET7/9 (unknown origin) after 60 mins by Alpha LISA assay				J Med Chem 60: 6289-6304 (2017) Article DOI: 10.1021/acs.jmedchem.7b00587 BindingDB Entry DOI: 10.7270/Q2D220XW
Shandong University Curated by ChEMBL					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 (Homo sapiens (Human))	BDBM50238541 (CHEMBL4092336) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Shandong University Curated by ChEMBL					Assay Description Inhibition of BRD4 (unknown origin) using SGRG-K(Ac)-GG-K(Ac)-GLG-K-(Ac)-GGA-K(Ac)-RHRKVGG-K(Biotin) peptide as substrate preincubated for 10 mins fo...				J Med Chem 60: 6289-6304 (2017) Article DOI: 10.1021/acs.jmedchem.7b00587 BindingDB Entry DOI: 10.7270/Q2D220XW
Shandong University Curated by ChEMBL					More data for this Ligand-Target Pair
Histone acetyltransferase KAT2A/KAT2B (Homo sapiens (Human))	BDBM50238541 (CHEMBL4092336) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Shandong University Curated by ChEMBL					Assay Description Inhibition of GCN5 (unknown origin) using H3 as substrate and Ac-CoA as cofactor preincubated for 10 mins followed by substrate/cofactor addition mea...				J Med Chem 60: 6289-6304 (2017) Article DOI: 10.1021/acs.jmedchem.7b00587 BindingDB Entry DOI: 10.7270/Q2D220XW
Shandong University Curated by ChEMBL					More data for this Ligand-Target Pair
PRMT5/MEP50 Enzyme (Homo sapiens (Human))	BDBM50238541 (CHEMBL4092336) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	987	n/a	n/a	n/a	n/a	n/a
Shandong University Curated by ChEMBL					Assay Description Binding affinity to PRMT5/MEP50 (unknown origin) by surface plasmon resonance assay				J Med Chem 60: 6289-6304 (2017) Article DOI: 10.1021/acs.jmedchem.7b00587 BindingDB Entry DOI: 10.7270/Q2D220XW
Shandong University Curated by ChEMBL					More data for this Ligand-Target Pair
PRMT5/MEP50 Enzyme (Homo sapiens (Human))	BDBM50238541 (CHEMBL4092336) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	330	n/a	n/a	n/a	n/a	n/a	n/a
Shandong University Curated by ChEMBL					Assay Description Inhibition of recombinant human N-terminal FLAG-tagged PRMT5 (2 to end residues) /human N-terminal His-tagged MEP50 (2 to end residues) expressed in ...				J Med Chem 60: 6289-6304 (2017) Article DOI: 10.1021/acs.jmedchem.7b00587 BindingDB Entry DOI: 10.7270/Q2D220XW
Shandong University Curated by ChEMBL					More data for this Ligand-Target Pair
Protein arginine N-methyltransferase 3 (Homo sapiens)	BDBM50238541 (CHEMBL4092336) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Shandong University Curated by ChEMBL					Assay Description Inhibition of human N-terminal GST-tagged PRMT3 (2 to end residues) expressed in Escherichia coli using histone H4 as substrate preincubated for 15 m...				J Med Chem 60: 6289-6304 (2017) Article DOI: 10.1021/acs.jmedchem.7b00587 BindingDB Entry DOI: 10.7270/Q2D220XW
Shandong University Curated by ChEMBL					More data for this Ligand-Target Pair
Protein arginine N-methyltransferase 1 (Homo sapiens)	BDBM50238541 (CHEMBL4092336) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Shandong University Curated by ChEMBL					Assay Description Inhibition of recombinant human N-terminal GST-tagged PRMT1 (2 to end residues) expressed in baculovirus infected Sf9 cell expression system using hi...				J Med Chem 60: 6289-6304 (2017) Article DOI: 10.1021/acs.jmedchem.7b00587 BindingDB Entry DOI: 10.7270/Q2D220XW
Shandong University Curated by ChEMBL					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase, H3 lysine-79 specific (Homo sapiens (Human))	BDBM50238541 (CHEMBL4092336) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Shandong University Curated by ChEMBL					Assay Description Inhibition of DOT1L (unknown origin) using biotinylated H3K79me2 as substrate preincubated for 15 mins followed by substrate/ SAM addition measured a...				J Med Chem 60: 6289-6304 (2017) Article DOI: 10.1021/acs.jmedchem.7b00587 BindingDB Entry DOI: 10.7270/Q2D220XW
Shandong University Curated by ChEMBL					More data for this Ligand-Target Pair