Found 5 hits for monomerid = 50238737 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Estrogen receptor
(Homo sapiens (Human)) | BDBM50238737
(CHEMBL4083658)Show SMILES OC(=O)\C=C\c1ccc(cc1)C(=C1C2CC3CC(C2)CC1C3)c1ccc(O)cc1 |TLB:11:12:14:18.16.17,THB:16:15:12:18.17.19,16:17:14.15.21:12,19:17:14:21.20.12,19:20:14:18.16.17,(2.75,-38.67,;4.08,-39.44,;4.08,-40.98,;5.42,-38.67,;6.75,-39.45,;8.08,-38.68,;8.09,-37.13,;9.42,-36.36,;10.75,-37.13,;10.76,-38.68,;9.42,-39.45,;12.08,-36.35,;13.42,-37.11,;13.43,-38.61,;12.23,-39.88,;13.72,-39.46,;15.14,-40.02,;16.14,-38.74,;14.75,-39.09,;16.16,-37.22,;14.76,-36.64,;13.72,-37.87,;12.08,-34.81,;13.41,-34.04,;13.4,-32.51,;12.07,-31.74,;12.06,-30.2,;10.73,-32.52,;10.74,-34.06,)| Show InChI InChI=1S/C26H26O3/c27-23-8-6-20(7-9-23)25(19-4-1-16(2-5-19)3-10-24(28)29)26-21-12-17-11-18(14-21)15-22(26)13-17/h1-10,17-18,21-22,27H,11-15H2,(H,28,29)/b10-3+,26-25- | PDB
UniProtKB/SwissProt UniProtKB/TrEMBL
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 0.400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute
Curated by ChEMBL
| Assay Description Displacement of [3H]estradiol from full-length human ERalpha receptor by scintillation counting |
J Med Chem 60: 6321-6336 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00585 BindingDB Entry DOI: 10.7270/Q2RB76V7 |
More data for this Ligand-Target Pair | |
Estrogen receptor
(Homo sapiens (Human)) | BDBM50238737
(CHEMBL4083658)Show SMILES OC(=O)\C=C\c1ccc(cc1)C(=C1C2CC3CC(C2)CC1C3)c1ccc(O)cc1 |TLB:11:12:14:18.16.17,THB:16:15:12:18.17.19,16:17:14.15.21:12,19:17:14:21.20.12,19:20:14:18.16.17,(2.75,-38.67,;4.08,-39.44,;4.08,-40.98,;5.42,-38.67,;6.75,-39.45,;8.08,-38.68,;8.09,-37.13,;9.42,-36.36,;10.75,-37.13,;10.76,-38.68,;9.42,-39.45,;12.08,-36.35,;13.42,-37.11,;13.43,-38.61,;12.23,-39.88,;13.72,-39.46,;15.14,-40.02,;16.14,-38.74,;14.75,-39.09,;16.16,-37.22,;14.76,-36.64,;13.72,-37.87,;12.08,-34.81,;13.41,-34.04,;13.4,-32.51,;12.07,-31.74,;12.06,-30.2,;10.73,-32.52,;10.74,-34.06,)| Show InChI InChI=1S/C26H26O3/c27-23-8-6-20(7-9-23)25(19-4-1-16(2-5-19)3-10-24(28)29)26-21-12-17-11-18(14-21)15-22(26)13-17/h1-10,17-18,21-22,27H,11-15H2,(H,28,29)/b10-3+,26-25- | PDB
UniProtKB/SwissProt UniProtKB/TrEMBL
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute
Curated by ChEMBL
| Assay Description Downregulation of ERalpha in human MCF-7 cells assessed as reduction of estradiol-induced pS2 mRNA levels after 24 hrs by RT-PCR method |
J Med Chem 60: 6321-6336 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00585 BindingDB Entry DOI: 10.7270/Q2RB76V7 |
More data for this Ligand-Target Pair | |
Estrogen receptor
(Homo sapiens (Human)) | BDBM50238737
(CHEMBL4083658)Show SMILES OC(=O)\C=C\c1ccc(cc1)C(=C1C2CC3CC(C2)CC1C3)c1ccc(O)cc1 |TLB:11:12:14:18.16.17,THB:16:15:12:18.17.19,16:17:14.15.21:12,19:17:14:21.20.12,19:20:14:18.16.17,(2.75,-38.67,;4.08,-39.44,;4.08,-40.98,;5.42,-38.67,;6.75,-39.45,;8.08,-38.68,;8.09,-37.13,;9.42,-36.36,;10.75,-37.13,;10.76,-38.68,;9.42,-39.45,;12.08,-36.35,;13.42,-37.11,;13.43,-38.61,;12.23,-39.88,;13.72,-39.46,;15.14,-40.02,;16.14,-38.74,;14.75,-39.09,;16.16,-37.22,;14.76,-36.64,;13.72,-37.87,;12.08,-34.81,;13.41,-34.04,;13.4,-32.51,;12.07,-31.74,;12.06,-30.2,;10.73,-32.52,;10.74,-34.06,)| Show InChI InChI=1S/C26H26O3/c27-23-8-6-20(7-9-23)25(19-4-1-16(2-5-19)3-10-24(28)29)26-21-12-17-11-18(14-21)15-22(26)13-17/h1-10,17-18,21-22,27H,11-15H2,(H,28,29)/b10-3+,26-25- | PDB
UniProtKB/SwissProt UniProtKB/TrEMBL
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute
Curated by ChEMBL
| Assay Description Downregulation of ERalpha in human MCF-7 cells assessed as reduction of estradiol-induced PgR mRNA levels after 24 hrs by RT-PCR method |
J Med Chem 60: 6321-6336 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00585 BindingDB Entry DOI: 10.7270/Q2RB76V7 |
More data for this Ligand-Target Pair | |
Estrogen receptor
(Homo sapiens (Human)) | BDBM50238737
(CHEMBL4083658)Show SMILES OC(=O)\C=C\c1ccc(cc1)C(=C1C2CC3CC(C2)CC1C3)c1ccc(O)cc1 |TLB:11:12:14:18.16.17,THB:16:15:12:18.17.19,16:17:14.15.21:12,19:17:14:21.20.12,19:20:14:18.16.17,(2.75,-38.67,;4.08,-39.44,;4.08,-40.98,;5.42,-38.67,;6.75,-39.45,;8.08,-38.68,;8.09,-37.13,;9.42,-36.36,;10.75,-37.13,;10.76,-38.68,;9.42,-39.45,;12.08,-36.35,;13.42,-37.11,;13.43,-38.61,;12.23,-39.88,;13.72,-39.46,;15.14,-40.02,;16.14,-38.74,;14.75,-39.09,;16.16,-37.22,;14.76,-36.64,;13.72,-37.87,;12.08,-34.81,;13.41,-34.04,;13.4,-32.51,;12.07,-31.74,;12.06,-30.2,;10.73,-32.52,;10.74,-34.06,)| Show InChI InChI=1S/C26H26O3/c27-23-8-6-20(7-9-23)25(19-4-1-16(2-5-19)3-10-24(28)29)26-21-12-17-11-18(14-21)15-22(26)13-17/h1-10,17-18,21-22,27H,11-15H2,(H,28,29)/b10-3+,26-25- | PDB
UniProtKB/SwissProt UniProtKB/TrEMBL
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute
Curated by ChEMBL
| Assay Description Downregulation of human ERalpha in human MCF-7 cells after 24 hrs by in-cell Western immunoassay method |
J Med Chem 60: 6321-6336 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00585 BindingDB Entry DOI: 10.7270/Q2RB76V7 |
More data for this Ligand-Target Pair | |
Estrogen receptor
(Homo sapiens (Human)) | BDBM50238737
(CHEMBL4083658)Show SMILES OC(=O)\C=C\c1ccc(cc1)C(=C1C2CC3CC(C2)CC1C3)c1ccc(O)cc1 |TLB:11:12:14:18.16.17,THB:16:15:12:18.17.19,16:17:14.15.21:12,19:17:14:21.20.12,19:20:14:18.16.17,(2.75,-38.67,;4.08,-39.44,;4.08,-40.98,;5.42,-38.67,;6.75,-39.45,;8.08,-38.68,;8.09,-37.13,;9.42,-36.36,;10.75,-37.13,;10.76,-38.68,;9.42,-39.45,;12.08,-36.35,;13.42,-37.11,;13.43,-38.61,;12.23,-39.88,;13.72,-39.46,;15.14,-40.02,;16.14,-38.74,;14.75,-39.09,;16.16,-37.22,;14.76,-36.64,;13.72,-37.87,;12.08,-34.81,;13.41,-34.04,;13.4,-32.51,;12.07,-31.74,;12.06,-30.2,;10.73,-32.52,;10.74,-34.06,)| Show InChI InChI=1S/C26H26O3/c27-23-8-6-20(7-9-23)25(19-4-1-16(2-5-19)3-10-24(28)29)26-21-12-17-11-18(14-21)15-22(26)13-17/h1-10,17-18,21-22,27H,11-15H2,(H,28,29)/b10-3+,26-25- | PDB
UniProtKB/SwissProt UniProtKB/TrEMBL
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute
Curated by ChEMBL
| Assay Description Downregulation of ERalpha in human MCF-7 cells assessed as reduction of estradiol-induced GREB1 mRNA levels after 24 hrs by RT-PCR method |
J Med Chem 60: 6321-6336 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00585 BindingDB Entry DOI: 10.7270/Q2RB76V7 |
More data for this Ligand-Target Pair | |