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SMILES: CN1CCN(CCCn2c3ccccc3c(=O)c3cc(C)cc(C)c23)CC1

InChI Key: InChIKey=SGEIISAQAQTACA-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50238977   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
ATP-dependent translocase ABCB1


(Homo sapiens (Human))		BDBM50238977
PNG
(CHEMBL4073625)
Show SMILES CN1CCN(CCCn2c3ccccc3c(=O)c3cc(C)cc(C)c23)CC1
Show InChI InChI=1S/C23H29N3O/c1-17-15-18(2)22-20(16-17)23(27)19-7-4-5-8-21(19)26(22)10-6-9-25-13-11-24(3)12-14-25/h4-5,7-8,15-16H,6,9-14H2,1-3H3
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PubMed
n/an/a 17n/an/an/an/an/an/a



SVKM's Dr. Bhanuben Nanavati College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of ABCB1 in human MCF7/ADR cells assessed as potentiation of vinblastine-induced cytotoxicity by measuring vinblastine IC50 at IC10 after ...

Eur J Med Chem 130: 154-170 (2017)


Article DOI: 10.1016/j.ejmech.2017.02.022
BindingDB Entry DOI: 10.7270/Q26D5W99
More data for this
Ligand-Target Pair