BindingDB PrimarySearch

BDBM50240181 CHEMBL4060262::US9962398, Compound MST-138

SMILES: NS(=O)(=O)c1ccc(NC(=O)Nc2cc(ccc2F)C(F)(F)F)cc1

InChI Key: InChIKey=ABEMFKBBOBRDNL-UHFFFAOYSA-N

Data: 8 KI

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50240181
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Carbonic anhydrases IX (Homo sapiens (Human))	BDBM50240181 (CHEMBL4060262 \| US9962398, Compound MST-138) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	7.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Washington at Seattle					Assay Description CA INHIBITION DATA WITH UREIDOSUBSTITUTED SULFONAMIDES				J Med Chem 52: 1864-72 (2009) BindingDB Entry DOI: 10.7270/Q2Q242KS
University of Washington at Seattle					More data for this Ligand-Target Pair
Carbonic anhydrases; II & IX (Homo sapiens (Human))	BDBM50240181 (CHEMBL4060262 \| US9962398, Compound MST-138) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	7.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Firenze Curated by ChEMBL					Assay Description Inhibitory activity against dog gastric proton-pump enzyme H+/K+ ATPase				Bioorg Med Chem 25: 2569-2576 (2017) Article DOI: 10.1016/j.bmc.2017.03.027 BindingDB Entry DOI: 10.7270/Q22F7QKP
Universit£ degli Studi di Firenze Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase (Homo sapiens (Human))	BDBM50240181 (CHEMBL4060262 \| US9962398, Compound MST-138) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Firenze Curated by ChEMBL					Assay Description Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopp...				Bioorg Med Chem 25: 2569-2576 (2017) Article DOI: 10.1016/j.bmc.2017.03.027 BindingDB Entry DOI: 10.7270/Q22F7QKP
Universit£ degli Studi di Firenze Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase XII (Homo sapiens (Human))	BDBM50240181 (CHEMBL4060262 \| US9962398, Compound MST-138) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	10.1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Washington at Seattle					Assay Description CA INHIBITION DATA WITH UREIDOSUBSTITUTED SULFONAMIDES				J Med Chem 52: 1864-72 (2009) BindingDB Entry DOI: 10.7270/Q2Q242KS
University of Washington at Seattle					More data for this Ligand-Target Pair
Carbonic anhydrase 2 (Homo sapiens (Human))	BDBM50240181 (CHEMBL4060262 \| US9962398, Compound MST-138) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	170	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Washington at Seattle					Assay Description CA INHIBITION DATA WITH UREIDOSUBSTITUTED SULFONAMIDES				J Med Chem 52: 1864-72 (2009) BindingDB Entry DOI: 10.7270/Q2Q242KS
University of Washington at Seattle					More data for this Ligand-Target Pair
Carbonic anhydrase 2 (Homo sapiens (Human))	BDBM50240181 (CHEMBL4060262 \| US9962398, Compound MST-138) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	170	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Firenze Curated by ChEMBL					Assay Description Inhibitory activity of gastric proton-pump enzyme H+/K+ ATPase was determined at 50 uM				Bioorg Med Chem 25: 2569-2576 (2017) Article DOI: 10.1016/j.bmc.2017.03.027 BindingDB Entry DOI: 10.7270/Q22F7QKP
Universit£ degli Studi di Firenze Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase I (Homo sapiens (Human))	BDBM50240181 (CHEMBL4060262 \| US9962398, Compound MST-138) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	363	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Washington at Seattle					Assay Description CA INHIBITION DATA WITH UREIDOSUBSTITUTED SULFONAMIDES				J Med Chem 52: 1864-72 (2009) BindingDB Entry DOI: 10.7270/Q2Q242KS
University of Washington at Seattle					More data for this Ligand-Target Pair
Carbonic anhydrase (Homo sapiens (Human))	BDBM50240181 (CHEMBL4060262 \| US9962398, Compound MST-138) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	363	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Firenze Curated by ChEMBL					Assay Description The compound was tested in vivo for inhibition of gastric proton-pump enzyme H+/K+ ATPase				Bioorg Med Chem 25: 2569-2576 (2017) Article DOI: 10.1016/j.bmc.2017.03.027 BindingDB Entry DOI: 10.7270/Q22F7QKP
Universit£ degli Studi di Firenze Curated by ChEMBL					More data for this Ligand-Target Pair